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All Journal CHEMPUBLISH JOURNAL Indonesian Journal of Biological Pharmacy
Anjabtsawa, Daffa
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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A Review of Antidiabetic Potential of Indonesian Medicinal Plants on Streptozotocin (STZ)-Induced Rats Anjabtsawa, Daffa; Febriyanti, Raden Maya; Diantini, Ajeng
Indonesian Journal of Biological Pharmacy Vol 4, No 1 (2024): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i1.54037

Abstract

Diabetes mellitus represents a chronic pathological state affecting a substantial portion of the global population, characterized by elevated levels of blood glucose. The International Diabetes Federation (IDF) documented in 2022 an estimated 537 million individuals aged 20-79 afflicted with this condition. Indonesia is home to various medicinal plants used for centuries to treat various ailments, including diabetes. Some of these plants have been found to have antidiabetic properties and are currently being studied for their potential use in treating diabetes. This review integrates the potential of indigenous Indonesian medicinal plants as antidiabetic agents. Twenty-two herbal species native to Indonesia were examined in diabetic-rat models, revealing promising efficacy as alternatives to conventional antihyperglycemic therapies. These medicinal plants' bioactive constituents, including flavonoids, alkaloids, phenolics, tannins, saponins, steroids, triterpenoids, and glycosides, are hypothesized to modulate glucose metabolism. Data acquisition encompassed scholarly databases such as PubMed, Scopus, Cochrane, Google Scholar, ScienceDirect, and EBSCO, spanning literature published between 2017 and 2023. The investigation underscores the notable reduction in blood glucose levels observed in rats administered doses ranging from 100 to 800 mg/kg body weight (BW). Furthermore, the antihyperglycemic evaluation in rats involved dosing at 40-65 mg/kg BW, eliciting a sustained hyperglycemic state.
Exploring the Phytochemical Properties and Therapeutic Potential of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. Anjabtsawa, Daffa; Febriyanti, Raden Maya; Diantini, Ajeng
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i2.54035

Abstract

Indonesian people have used medicinal plants for ages to cure various diseases. Traditional medicinal plants offer a variety of health benefits and can be an excellent alternative to prevent various diseases. Herbal tea-based treatment is low-calorie and is good for health with many benefits. Rosella (Hibiscus sabdariffa Linn.) and Stevia (Stevia rebaudiana Bert.) plants are the main composition of herbal tea. They contain various secondary metabolite compounds that play a role in pharmacological activity like alkaloids, flavonoids, phenols, glycosides, steroids, tannins, coumarins, saponins, anthraquinones, and others. This review aims to collect the latest scientific information regarding the possible pharmacological activities of Rosella and Stevia plants. These plants have antioxidative, antibacterial, antidiabetic, antihypertensive, anticancer, antihyperlipidemia, anti-obesity, hepatoprotective, anti-inflammatory, and antiprotozoal potential. PubMed, Scopus, Cochrane, Google Scholar, ScienceDirect, and EBSCO were used to obtain literature published from 2017 to 2023. The study concludes that Rosella (Hibiscus sabdariffa Linn.) and Stevia (Stevia rebaudiana Bert.) plants have potential in the development of traditional medicinal plants with many benefits contained in them.
Antidiabetic activity of combined extracts of Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. on streptozotocin-induced diabetes Wistar rats Tjitraresmi, Ami; Febriyanti, Raden Maya; Anjabtsawa, Daffa; Susilawati, Yasmiwar; Muhaimin, Muhaimin
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46449

Abstract

The increasing prevalence of diabetes mellitus and the limitation in its conventional therapies underscores the need for alternative treatments. Hibiscus sabdariffa Linn. and Stevia rebaudiana Bert. have demonstrated individual antidiabetic activities attributed to their secondary metabolites, including flavonoid and phenolic compounds. This study employed an experimental in vivo design using rats induced with STZ. Thirty rats were divided into five groups (n=6): normal control, negative control, positive control (Glibenclamide), and two treatment groups receiving the combined aqueous extracts of H.sabdariffa and S.rebaudiana (RSAE) at 500 and 1000 mg/kgBW. Diabetes was induced using STZ (50 mg/kgBW administered i.p). Blood glucose levels were measured fasting and 2 hr postprandial at days 0, 3, and 14 after administration of RSAE. Data were analyzed using One-Way ANOVA. RSAE exhibited dose‐dependent hypoglycaemic activity in STZ‐induced diabetic rats, significantly reducing (p < .005) fasting blood glucose by up to 50.7 % and two‐hour post‐prandial glucose by 44.97% at 1000 mg/kgBW.
Co-Authors Ajeng Diantini, Ajeng Ami Tjitraresmi, Ami Muhaimin Muhaimin Raden Maya Febriyanti Yasmiwar Susilawati