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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Journal of World Future Medicine, Health and Nursing
Ramadhani, Arba Pramundita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Immunostimulant Activity of Moringa Leaves (Moringa Oleifera Lam.) Combined with Lime Peel (Citrus Aurantifolia) in Vitro Tenda, Priska Ernestina; Ramadhani, Arba Pramundita
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 1 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i1.724

Abstract

Moringa leaves (Moringa Oleifera Lam.) are known to have many chemical contents such as vitamin A, vitamin C, flavonoids, phenolic compounds, carotenoids, tannins and triterpenoids with high uses, one of which is as an immunostimulant. Previous researchers reported that moringa leaves have been developed in various preparations but have not been able to cover the problem of the smell and taste of moringa leaves that are less accepted by consumers. In this study, moringa leaves were combined with lime peel ginger (Citus aurantifolia) to cover the taste and smell of moringa leaves. This study aims to determine the immunostimulant activity of moringa and lime peel in three formulas.  Formula F1= moringa:lime peel (1:1); F2= moringa:lime peel (2:1) F3= moringa:lime peel (3:1); F4= moringa extract. The research conducted was experimental research with the research design used was a completely randomised design and three different treatments with three repetitions. Each treatment was repeated 3 times so that 12 experimental units were obtained. Statistical analysis using the probit test. The results of plant identification showed true moringa leaves and lime peel with chemical content of flavonoids, tannins, terpenoids, alkaloids, saponins based on the results of colour recreation. The IC50 value of immunostimulant activity test of the best formula of tea as immunostimulant is F4, F3, F2 and F1 respectively: 701.83 ± 113.36; 701.83 ± 113.36; 488.08 ± 139.60; 488.08 ± 139.60 µg/mL. Overall, the formulas have the potential to be developed as immunostimulants.
Aktivitas pegagan (Centella asiatica) pada dermatologi Fernenda, Larysa; Ramadhani, Arba Pramundita; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.237-244.2022

Abstract

Pegagan (Centella asiatica L.) is a herbal plant used in dermatology that has activity in treating skin diseases and skin lesions such as excoriations, burns, hypertrophic scars, antioxidants, anti-aging, skin whitening, and as a cosmetic ingredient. This review aims to collect data regarding the activity of Centella asiatica herb extracts in dermatology in both preclinical and clinical trial identification is done by searching literature through media Science Direct and Google Scholar using the keywords ''Centella asiatica'', ''Gotu kola'', ''dermatology'', ''cosmetics'', and ''whitening''. The search was based on the inclusion and exclusion criteria that had been set. The literature results show that the chemical constituents of Centella asiatica, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, are phytochemicals that play an essential role in the pharmacological activity of Centella asiatica in dermatology as a treatment and skin care. In both preclinical and clinical tests, it was shown that administration of Centella asiatica was capable of proliferating fibroblasts, activating the Smads pathway, increasing collagen synthesis, reducing metalloproteinase activity by increasing collagen deposition, and reducing melanin content in melanocytes so that it can modulate melanogenesis by inhibiting the expression of tyrosinase mRNA.
Formulation and Characterization of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Loading Curcuma xanthorrhiza Extract Syukri, Yandi; Seran, Yuvina; Hannie Fitriani; Ramadhani, Arba Pramundita; Taher, Muhammad
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.169-178.2024

Abstract

Curcuma xanthorrhiza has an active component xanthorrhizol that is poorly soluble in water, resulting in limited absorption and bioavailability. Liquid Self Nano Emulsifying Drug Delivery System (SNEDDS) dosage formulations can improve its solubility and absorption due to its small particle size. Solid SNEDDS technology significantly overcomes some of problems in liquid SNEDDS preparations to improve the stability of liquid formulations. This study aims to formulate and characterize Curcuma xanthorrhiza S-SNEDDS preparation. SNEDDS was characterized by particle size and thermodynamic tests. Method of making S-SNEDDS uses two ways, absorption of porous compounds and spray drying. S-SNEDDS were characterized by testing infrared spectra, X-ray diffraction, scanning electron microscopy, microbial contamination and particle flow properties. Optimal S-SNEDDS formulation with 2 formulas namely F7 and F11 mannitol carrier. FTIR testing showed no interacting compounds. SEM and X-ray diffraction testing of F7 showed that the preparation was semicrystalline. While F11 described the preparation as much more crystalline due to the high content of mannitol. The microbial contamination test detected no microorganism compounds. In addition, the particle flow properties obtained a result of 02.53 seconds with a height of 24.95 mm. It is concluded that the S-SNEDDS formula F7 of Curcuma xanthorrhiza has semicrystalline preparation criteria.
Co-Authors Fernenda, Larysa Hannie Fitriani Priska Ernestina Tenda Seran, Yuvina Taher, Muhammad Yandi Syukri