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All Journal Tropical Medicine Journal Jurnal Kesehatan Prima Academic Journal Perspective : Education, Language, and Literature Jurnal Farmasi Sains dan Praktis Jurnal Katalisator Journal of World Future Medicine, Health and Nursing Indonesian Journal of Pharmacology and Therapy Jurnal Info Kesehatan

Priska Ernestina Tenda

Poltekkes Kemenkes Kupang

Author-ID : 402572

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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In Vitro Antiplasmodial Activity of Brucein A Semisynthetic Compounds Priska Ernestina Tenda; Eti Nurwening Solikhah; Mahardika Agus Wijayanti
Tropical Medicine Journal Vol 2, No 1 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Introduction: Brucein A has been known to have antiplasmodial activity. Some new compounds were synthesized to increase their antiplasmodial activity, i.e 3-benzoylbruceinA, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.However, their antiplasmodial activity have not studied yet.Objectives: To know the in vitro antiplasmodial activity of 3-benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.Methods: Antiplasmodial activity was conducted by incubating FCR-3 strain of P. falciparum with 3- benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A in various concentrations for 72 hours. Parasitemia after incubation period of each compound was calculated by making a thin smear stained with 5% Giemsa.Results: Semisynthetic compounds of bruceine A have antiplasmodial activity in vitro with IC50 value were 2.648 ± 1.30 ng/mL for 3-benzoyl bruceine A, 1.098 ± 0.510 ng/mL for 3-dimethyl sulphate bruceine A, 50.246 ± 0.207 ng/mL for 3-chloro benzoyl bruceine A and 67.951 ± 11.517 ng/mL for 3- chloro acetyl brucein A. The IC50 value of Bruceine A as the lead compound was 3.87 ± 2.530 ng/mLConclusion: The 3-dimethyl sulphate bruceine A showed the highest antiplasmodial activity among 4 semisynthetic compounds of Bruceine A.Keywords:bruceineA, semisynthetic compound, Plasmodiumfalciparum, invitroantiplasmodial activity.

Assessment of Job Risks in the Chemical Laboratory of the Pharmacy Study Program with Job Safety Analysis (JSA) Techniques Priska Ernestina Tenda; Faizal Reza Soeharto
Jurnal Kesehatan Prima Vol 15, No 2 (2021): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v15i2.689

Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously. Chemistry laboratory organizes practicum, one of them quantitative pharmaceutical chemistry which uses a variety of chemicals and tools where if not careful, not following instructions or procedures even underestimate will cause work accidents and/ or occupational illness. Is observational descriptive research on the job risk assessments in chemical laboratories prodi pharmacy with JSA techniques aimed at finding out the risk of work performed. Population is type practicum work in chemistry laboratory and the sample is quantitative pharmaceutical chemistry practicum. Data collection techniques i.e. the work that has been selected is further determined with the working procedure and the working steps and then determines the findings of errors from each step of the work then further identify the potential hazards of each step of the work. Data analysis techniques is data from each finding of errors determined potential injury / danger / loss and its impact is then calculated risk value (risk matrix) i.e. the value of consequences multiplied by opportunity value where the results are could grouped into risk extreme, high, medium or low that continued with to determine safeguards measures that can be done to control the such danger. The results showed that performs the titration step has high very risk level value compared to another work step other of pharmaceutical chemical practicum quantitative. Titration activities carry an extreme or significant risk of harm when performed incompatible with working measures and unsafe with potential danger (disadvantage) is liquid evaporates (inhaled), disturbances The End Point of the Titration: change in color and determination of concentration, and perform movements manual repetitive continuously namely mixing the liquid or rotating the container (erlenmeyer) contains a chemical liquid by hand continuously.

Immunostimulant Activity of Moringa Leaves (Moringa Oleifera Lam.) Combined with Lime Peel (Citrus Aurantifolia) in Vitro Tenda, Priska Ernestina; Ramadhani, Arba Pramundita
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 1 (2024)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i1.724

Moringa leaves (Moringa Oleifera Lam.) are known to have many chemical contents such as vitamin A, vitamin C, flavonoids, phenolic compounds, carotenoids, tannins and triterpenoids with high uses, one of which is as an immunostimulant. Previous researchers reported that moringa leaves have been developed in various preparations but have not been able to cover the problem of the smell and taste of moringa leaves that are less accepted by consumers. In this study, moringa leaves were combined with lime peel ginger (Citus aurantifolia) to cover the taste and smell of moringa leaves. This study aims to determine the immunostimulant activity of moringa and lime peel in three formulas. Formula F1= moringa:lime peel (1:1); F2= moringa:lime peel (2:1) F3= moringa:lime peel (3:1); F4= moringa extract. The research conducted was experimental research with the research design used was a completely randomised design and three different treatments with three repetitions. Each treatment was repeated 3 times so that 12 experimental units were obtained. Statistical analysis using the probit test. The results of plant identification showed true moringa leaves and lime peel with chemical content of flavonoids, tannins, terpenoids, alkaloids, saponins based on the results of colour recreation. The IC50 value of immunostimulant activity test of the best formula of tea as immunostimulant is F4, F3, F2 and F1 respectively: 701.83 ± 113.36; 701.83 ± 113.36; 488.08 ± 139.60; 488.08 ± 139.60 µg/mL. Overall, the formulas have the potential to be developed as immunostimulants.

PENILAIAN RISIKO PERALATAN DI LABORATORIUM FARMASETIKA PROGRAM STUDI FARMASI Faizal Soeharto; Priska Ernestina Tenda; Maria Imakulata Masiya Indrawati; Ratih Variani
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2614

Pengerjaan penelitian Kimia di Laboratorium yang menggunakan alat-alat kimia semetinya selalu diperhatikan resikonya. Belum banyak yang mempelajari mengenai kesehatan dan keselamatan kerja di Laboratorium kimia saat berlansungnya aktivitas penelitian maupun praktikum. Tetapi hal ini sangat diperlukan karena kalau tidak, akan memahayakan. sehingga penelitian ini bertujuan mempelajari penilaian risiko peralatan di laboratorium Farmasetika. Metodenya adalah deskriptif observasional dimana populasi adalah peralatan standar di laboratorium Farmasetika dan sampelnya peralatan yang menimbulkan risiko tinggi. Teknik pengambilan sampel purposif. Instrumen penelitian adalah mengamati dan mengidentifikasi potensi bahaya peralatan dengan lembar What-If. Teknik pengumpulan data adalah menentukan pertanyaan bahaya “Bagaimana Jika” dari kondisi peralatan, deskripsi konsekuensi, nilai konsekuensi, nilai peluang bahaya untuk mendapat nilai risiko dan peringkat risiko. Data dianalisis setelah menentukan nilai risiko dan peringkat risiko, maka ditentukan pengamanan bahaya, rekomendasi pengendalian, tanggung jawab pengendalian. Hasil penelitian menunjukkan kegiatan yang menimbulkan risiko tinggi di laboratorium Farmasetika terkait praktikum Farmasetika dasar adalah meleburkan atau memanaskan dan menimbang karena menggunakan lampu spritus, waterbath digital, neraca elektronik digital portable yang menggunakan api dan listrik dalam proses kerjanya. Ada nilai tingkat risiko tertinggi 16 (peringkat risiko ekstrim) akibat penggunaan peralatan tidak standar dan penggunaan keliru yaitu wadah botol bahan obat dan neraca (elektronik digital dan sama lengan).

Hubungan Antara Pencatatan Pelaporan Laporan Pemakaian-Lembar Permintaan Obat (LP-LPO) Dengan Perencanaan Obat Di Gudang Farmasi Dinas Kesehatan Kabupaten Manggarai Theodorik Erik Nara; ELISMA ELISMA; PRISKA ERNESTINA TENDA
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar

The recording of drug data reporting at Regency/City Pharmacy is a series of activities in order to manage medicine in an orderly manner either medicine received, stored, distributed or used in health care unit such as Puskesmas. This study aims to calculate the highest number of drug use in Pharmaceutical Warehouse of Manggarai District Health Office based on LP-LPO reporting in 2012 and 2013, to know drug planning in 2013 and 2014 and to analyze the relationship between LP-LPO reporting in 2012 and 2013 with drug planning in 2013 and 2014. This type of research is descriptive research. The results showed that the most used drugs in 2012 and 2013 were Iron II sulfate tablet combination 13.92% and Ascorbic acid 500 mg tablet 21.69%. The drugs with the highest ranking in 2012 and 2013 are Antalgin 500 mg tablet 4.72% and Dexamethasone 0.5 mg tablet 3.40%. Drugs with the largest planning in 2012 and 2013 are Antacids DOEN combination tablets (655,000 tablets) and Amoxicillin 500 mg (1,148,000 tablets). The tenth-grade drug with the smallest planning of 2012 and 2013 is Iron II sulfate combination coated tablet (60,000 tablets in 2012 and 40,000 tablets in 2013. Record of LP-LPO reporting in 2012 with 2013 drug planning and LP-LPO reporting record in 2013 with Drug planning in 2014 has a fairly close relationship.

Uji Aktivitas Antibakteri Ekstrak Etanol Kulit Pohon Faloak (Sterculia sp.) Terhadap Bakteri Staphylococcus Aureus Priska Ernestina Tenda; Maria Yangsye Lenggu; Marini Sriyuni Ngale
JURNAL INFO KESEHATAN Vol 15 No 1 (2017): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

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Faloak is a medicinal plant that grows in extreme conditions in the East Nusa Tenggara region. Faloak has benefits for herbal treatment wherein the content of saponin compounds, steroids and triterpenoids, flavonoids, and alkaloids found in the bark of the faloak tree serves for the treatment of various diseases caused by bacteria. The purpose of this research is to know the antibacterial activity of ethanol extract of faloak bark (Sterculia sp.) On the growth of Staphylococcus aureus bacteria. Determination of antibacterial activity by a diffusion method using a cylinder, and see the existence of a clear zone around a cylinder. The results showed that the concentration of 22.5% w / v; 45% w / v; 75% w / v and 100% w / v were able to inhibit the growth of Staphylococcus aureus bacteria with mean inhibitory zone diameter of 1.33 cm, 1.66 cm, 1.90 cm, 2.13 cm, the concentration of the inhibitory zone is greater so that the effective concentration inhibiting the growth of Staphylococcus aureus bacteria is 100% w / v.

Anti-Cholesterolemic Activity of Mulberry (Morus australis Poir) Ethanol Extract in Increasing HDL Levels and Inhibiting Formation of Foam Cells on Rat Priska Ernestina Tenda; Eleonora Maryeta Toyo
JURNAL INFO KESEHATAN Vol 19 No 1 (2021): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Politeknik Kesehatan Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol19.Iss1.497

Mulberry leaves are one of the medicinal plants empirically used by people to reduce cholesterol levels. Previous study found that mulberry leaves contain flavonoids, act as cholesterol-lowering and tannins function to inhibit the absorption of food, including fat in the GI tract. The objective of this study is to determine the effect of mulberry leaf ethanol extract on increased HDL levels and to determine the inhibition of the formation of foam cells in male Wistar strain rats given the atherogenic diet. Thirty male Wistar rats were divided into six groups, which were normal group, negative control, positive control, and three groups of mulberry leaf extract at a dose of 25, 50, and 100 mg/200g BW rats, respectively. The HDL levels were measured pre- and post- treatment on days 0, 28, 35 and 42. The results showed that the most effective dose augmenting the HDL as well as inhibited the formation of aortic wall foam cell was the ethanol extract at a dose of 100 mg/200 g BW. In conclusion, mulberry leaves ethanolic extract have the potency to be developed as a natural cholesterol-lowering agent.

POTENTIAL PHARMACOLOGICAL ACTIVITIES OF FALOAK BARK (STERCULIA QUADRIFIDA R. BR) AS AN HERBAL PLANT FROM EAST NUSA TENGGARA: A SCOPING REVIEW Fuadah, Shofiatul; Istikharah, Rochmy; Tenda, Priska Ernestina; Ramadani, Arba Pramundita
Jurnal Farmasi Sains dan Praktis Vol 11 No 1 (January-April 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i1.10862

Faloak bark (Sterculia quadrifida R. Br) is part of the faloak plant, which has been used for a long time in traditional medicine to treat a variety of medical conditions. Faloak bark is claimed to possess medicinal properties that can treat liver, kidney, and bladder diseases, cure gastroenteritis, hepatitis, anemia, malaria, back pain, and function as an energy booster. Recent studies in pharmacology have found that faloak bark has several interesting biological properties, thus strengthening its potential as a new source of active ingredients for pharmaceutical development. This study literature aims to provide a concise overview of the evaluations of the secondary metabolite chemicals found in faloak bark, thus highlighting their potential pharmacological properties. To find articles for the review of the pharmacological activities of faloak bark, a search was conducted on research journal databases using Publish or Perish 8, and 43 papers relevant to the evaluation were found. Literature review showed that faloak bark contains many different chemicals, such as alkaloids, gallic acid derivatives, flavonoids, polyphenols, saponins, steroids, tannins, terpenoids, triterpenoids, quinone, glycoside, as well as isolates of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione, and 2-iminoethyl 2-(1-hydroxypentan-2-yl) phenyl) acetate. Faloak bark has such pharmacological properties as antiaging, antibacterial, antibiofilm, anti-dengue, antifungal, anti-hepatitis C, anti-hyperglycemia, anticancer, antimalarial, antioxidant, antipyretic, and immunomodulatory effects. Therefore, faloak bark has considerable potential for the advancement of herbal remedies.

COMPARATIVE STUDY ON THE INTEGRATION OF TPACK IN TEACHING PRACTICES Mola, Manusetus; Santosa, Made Hery; Tenda, Priska Ernestina
Academic Journal PERSPECTIVE: Education, Language, and Literature Vol 13 No 2 (2025)
Publisher : Lembaga Penelitian (The Institute of Research) Universitas Swadaya Gunung Jati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/perspective.v13i2.10252

This study aims to compare the levels of mastery and implementation of Technological Pedagogical Content Knowledge (TPACK) in three study programs at San Pedro University (UNISAP): English Language Education (PBI), Primary School Teacher Education (PGSD), and Physical Education, Health, and Recreation (PJKR). The background of this study is the need to strengthen the integration of technology, pedagogy, and content in digital-based higher education. The research uses a comparative quantitative approach involving 30 lecturers (10 per Study Program) selected through purposive sampling. Data were collected using a TPACK questionnaire based on seven dimensions and analyzed with descriptive statistics and one-way ANOVA to determine differences between programs. Results show that PBI lecturers have the highest TPACK scores (average 4.61), followed by PGSD (4.18) and PJKR (3.93). ANOVA tests indicate significant differences (F (2,27) = 7.932, p < 0.01). Further Tukey HSD tests reveal significant differences between PBI and PJKR (p = 0.004) and between PBI and PGSD (p = 0.026), while the difference between PGSD and PJKR is not significant (p = 0.111). These results indicate the influence of factors such as disciplinary characteristics, technological readiness, and institutional support on variations in TPACK mastery. This study recommends the development of lecturer training tailored to the needs of each study program as a strategy to enhance professional capacity in technology integration in teaching.

Qualitative Study and Antioxidant Activity Herbal Tea Bag of Moringa Leaves (Moringa oleifera Lam.) and Red Ginger (Zingiber officinale var. Rubrum) Tenda, Priska Ernestina; Hilaria, Maria; Soeharto, Faizal R.; Najib, Mohd Nadzri Bin Mohd
JURNAL INFO KESEHATAN Vol 21 No 1 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Moringa (MO) leaves contain several chemical substances of high value, including vitamin C, flavonoids, phenolic compounds, carotenoids, tannins, and triterpenoids, among which one functions as an antioxidant. Previous research observed that MO leaves have already been developed into various formulations; unfortunately, these formulas could not completely obscure the aroma and taste problems that rendered MO leaves less acceptable to consumers. In this research, Moringa leaf powder (MLP) and red ginger (RG) are combined to cover the unpleasant taste and aroma of MO leaves. The purpose of this study assess the quality of three tea bag formulations, including their water content, ash content, hedonic and antioxidant activities, by quantitative tests; F0 (3 Gr of MLP), F1 (2.25 Gr of MLP, and 0.75 Gr of RG), and F2 (the amount of MLP and RG is equal to 1.5 Gr). This experimental study employs a completely randomized design, three special treatments, and three repetitions. Statistical analysis of quality test results and antioxidant activity uses One-Way ANOVA followed by a post hoc test utilizing the Least Significant Difference (LSD). The water content tests revealed that all three formulations qualified the Indonesian National Standard (SNI), ranging from 3.86% to 4.29%. Adding ginger did not influence the water content (p > 0.05). Otherwise, it increases the ash level from 8.65% to 9.98%. Based on the results of the hedonic test, the panelists preferred F0 over F1 and F2 concerning color by a score of 86%. In contrast, they preferred F2 regarding aroma and taste by a score of 82%. The addition of RG in F1 and F2 was significant to the preference level of panelists ('p <0.05). The IC50 value for the antioxidant activity test was highest for F2 at 59.31 ± 0.13 ppm. The addition of RG boosted the antioxidant activity of MO tea products considerably (sig <0.05). Consequently, developing MO tea products containing RG in F2 could be potentially produced as herbal tea beverages with antioxidant properties.

Co-Authors Arba Pramundita Ramadani Eleonora Maryeta Toyo Elisma Elisma Eti Nurwening Sholikhah Faizal Reza Soeharto Faizal Soeharto Fatmawati Blegur Fatmawati Blegur Fuadah, Shofiatul Jamhari Jamhari Lely A.V Kapitan Lely Adel Violin Kapitan Made Hery Santosa Mahardika Agus Wijayanti Maria Hilaria Maria Imakulata Masiya Indrawati MARIA YANGSYE LENGGU Marini Sriyuni Ngale Mola, Manusetus Najib, Mohd Nadzri Bin Mohd Nara, Theodorik Erik Ngale, Marini Sriyuni Ramadhani, Arba Pramundita Ratih Variani Rochmy Istikharah Soeharto, Faizal R. Theodorik Erik Nara

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