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All Journal Biomedical Journal of Indonesia Majalah Patologi Indonesia Jurnal Riset dan Pengabdian Masyarakat Jurnal RSMH Palembang
Sandria
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Dr. Mohammad Hoesin Hospitals Cancer Incidence: Hospital-Based Cancer Registration Data Dewi, Citra; Dian Puspita; Sandria; Romi Ramkita
Jurnal RSMH Palembang Vol. 4 No. 2 (2023): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v4i2.48

Abstract

Dr. Mohammad Hoesin Hospitals Cancer Incidence: Hospital-Based Cancer Registration Data. Cancer worldwide is summarized through a complex process called cancer registries. Based on data from the Global Burden of Cancer Study (GLOBOCAN), there will likely be approximately 10 million cancer-related deaths and 19.3 million new cases of cancer globally in 2020. However, Indonesia still does not have cancer incidence data based on population, as well as hospital-based cancer incidence data, especially the Dr. Mohammad Hoesin General Hospital Palembang, the main referral center for cancer in the South Sumatra region. This study aims to determine the distribution of cancer cases based on gender, age, organs, and cell origin in Dr. Mohammad Hoesin General Hospital Palembang for the period 2012-2019. This is an observational-descriptive study with 3413 samples taken from hospital cancer registry data, including topography, cell origin, age, and gender data from January 1, 2012, to December 31, 2019. The data is then processed and presented as distribution and frequency on tables and graphs using the SPSS application version 26. Cancer is prevalent in 63.5% of women and 36.5% of men. More than 53% of cases of cancer are diagnosed in the age range of 41-60 years. Acute lymphoblastic leukemia, infiltrating duct carcinoma, and adenocarcinoma are the most common cases of cancer in the age groups 0-20 years, 21-40 years, and >40 years, respectively. Based on location, breast, cervix-uteri, and colon occupy the 3rd highest position. By origin, 72% of cancer came from epithelial cells (carcinoma), 281 cases came from lymphoid cells (lymphoma), and 96 cases came from mesenchymal cells (sarcoma). Cancer generally occurs in females, patients aged 41-60 years, the most common location of the breast, and originates from epithelial cells (carcinoma).
Correlation between the Pre-Analytical Stage and Quality of Breast Histopathology Specimen Kurniawaty, Nyiayu Fauziah; Krisna Murti; Nora Ramkita; Sandria
Jurnal RSMH Palembang Vol. 5 No. 1 (2024): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v5i1.61

Abstract

The histopathology preparations procedure in the Anatomic Pathology Laboratory consists of three stages: pre-analytic, analytical and post-analytic. Errors in the pre-analytic process can affect the quality of histopathology preparations, thereby affecting diagnosis and patient management. The length of fixation and the large size of tissue lamellae are variables in the pre-analytic process that influence the quality of histopathological preparations. The aim of this study is to determine the relationship between the length of fixation and the size of large tissue lamellae on the quality of histopathological preparation. A cross-sectional study was conducted on medical record data of histopathological examination of breast tissue examined at the Barokah Palembang Anatomical Pathology Laboratory between January - December 2022. There were 37 cases of histopathological specimens that met the inclusion criteria, of which 3 cases were underfixed, 13 cases were overfixed and the rest were normal. One case from the underfixation, 20 cases from the normal fixation and 3 from the overfixation group were included in the good specimen quality category. The Spearman test showed that there was a significant relationship between normal fixation and good specimen quality (p=0.00217). Of the 37 research subjects, there were 18 subjects who were categorized as good lamellation. When related to specimen quality, good lamellation is associated with good specimen quality (p=0.02161). The correct fixation and lamellation during the pre-analytic phase are associated with good specimen quality.
Peningkatan Intelektual Anak-anak Melalui Program Perlombaan Anak Cerdas dan Berprestasi Hesti yusmanidar; Haikal Balyanda; Muammar Chalis; Munthasir; Rizkyna Mulva; Iklima Syara; Rahayu Windari; Naziła Fadillah; Sandria; Najwa Fathiya
Jurnal Riset dan Pengabdian Masyarakat Vol. 5 No. 1 (2025): Jurnal Riset dan Pengabdian Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LP2M) Universitas Islam Negeri Ar-Raniry Banda Aceh

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Abstract

Peningkatan intelektual anak-anak merupakan salah satu aspek penting dalam pengembangan potensi generasi muda. Program perlombaan "Anak Cerdas dan Berprestasi" yang diadakan di Gampong Sinyeu dirancang sebagai sarana untuk menumbuhkan minat belajar, kreativitas, dan daya saing anak-anak melalui aktivitas yang menyenangkan dan mendidik. Artikel ini membahas pentingnya program ini dalam membentuk pola pikir kritis, keterampilan problem solving, dan karakter positif sejak usia dini. Dengan pendekatan yang terstruktur dan kompetisi yang sehat, program ini tidak hanya meningkatkan kemampuan intelektual, tetapi juga mendorong rasa percaya diri, kerja sama tim, dan semangat juang. Penelitian menunjukkan bahwa anak-anak yang terlibat dalam kegiatan seperti ini cenderung memiliki performa akademik yang lebih baik serta kemampuan sosial yang lebih kuat.
Young-Onset Breast Carcinoma Tends to Show a Higher Proportion of Triple-Negative Subtype: A Comparative Molecular and Pathological Analysis Dewi, Citra; Sari, Nova; Sandria
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.330

Abstract

Introduction. Breast carcinoma in young women is often associated with more aggressive molecular profiles and suboptimal therapeutic responses. This study was designed to compare the molecular and histopathological characteristics of patients younger than 40 years with those aged 40 years and above. Methods. This study employed a retrospective descriptive-analytic design using clinical and pathological data from 36 patients diagnosed with invasive breast carcinoma. All cases were collected from the Department of Anatomical Pathology at Mohammad Hoesin General Hospital in Palembang, Indonesia, in 2023. Results. The molecular subtype profile was similarly distributed across the two age categories, with no statistically significant difference by age (p = 0.789). However, the younger cohort showed a relatively higher proportion of triple-negative cases. Luminal B remained the most prevalent molecular subtype in both groups. Likewise, ER, PR, and HER2 expression showed no significant differences according to age (p > 0.05). All patients exhibited high Ki-67 expression, and grade III was the predominant histological grade in both groups. Dominant TILs were observed in only a small fraction of cases, with no statistically significant age-related difference. Conclusion. Although younger patients showed a relative proportion of triple-negative cases and all tumors demonstrated high proliferative activity, no statistically significant differences in molecular subtype distribution or other clinicopathological parameters were identified between the two age groups. Luminal B remained the predominant molecular subtype in both groups. These findings suggest that age-related biological differences may exist, but larger studies are needed to clarify this association.
Profil tumor neuroendokrin berdasarkan pengalaman lima tahun di rumah sakit rujukan tersier di Palembang Sandria; Murti, Krisna
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.664

Abstract

Background Neuroendocrine tumors (NET) are a type of uncommon neoplasms originating from the neuroendocrine cell system. Recent decades, the prevalence of NET gradually increases, attributing partially to the utilization of advanced detection procedures using modern methodologies. Objective The aim of this research was to assess the profile of neuroendocrine tumors of 5 years experiences in our hospital. Methods In this retrospective cross-sectional study, a thorough examination was performed on a total of 71 cases obtained from archives of the Department of Anatomic Pathology Mohammad Hoesin Hospital, over the period from 2017 to 2021. The Chi-square test was used for data analysis. Bivariate analysis was performed using binary logistic regression tests to investigate the correlation between the independent variables, including gender and tumor site, and the dependent variables. Result and Discussion Out of the 71 recorded samples, 69 samples were subjected to be analyzed while the remaining samples were excluded due to have incomplete data. Four different antibodies were evaluated to find the association between these antibodies and tumor with location (chromogranin, P=0.792; synaptophysin, P=0.100; Ki-67, P=0.026; CD56, P=0.511) and gender (chromogranin, P=0.627; synaptophysin, P=0.929; Ki-67, P=0.315; CD56, P=0.524). Conclusion: The study showed synaptophysin has the highest positive rate on NET diagnosis. There is no association was found between chromogranin, synaptophysin, and CD56 staining to tumor location, except for Ki-67. Similarly, no association was found between staining performance (chromogranin, synaptophysin, Ki-67, CD56) with gender.
Co-Authors Citra Dewi Dian Puspita Haikal Balyanda Hesti yusmanidar Iklima Syara Krisna Murti Kurniawaty, Nyiayu Fauziah Muammar Chalis Munthasir Najwa Fathiya Naziła Fadillah Nora Ramkita Nova Sari, Nova Rahayu Windari Rizkyna Mulva Romi Ramkita