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All Journal Jurnal Integrasi Kesehatan dan Sains Jurnal RSMH Palembang Jurnal Riset Kedokteran
Yusuf, Khaidir
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Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Role of TNF-Alpha in the Wound Healing Process: Molecular and Clinical Perspectives - A Systematic Literature Review Yusuf, Khaidir
Jurnal RSMH Palembang Vol. 3 No. 2 (2022): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v3i2.53

Abstract

Wounds are conditions of damage and partial loss of body tissue caused by physical trauma, sharp objects, blunt objects, temperature fluctuations, chemical exposure. Wound healing is a complex interaction between cells, cytokines, mediators, and blood vessels as a natural physiological response to tissue damage. TNF-α has a crucial role in the wound healing process, facilitating body immunity, immune cell mobilization, fibroblast cell proliferation, keratinocytes, and growth factor expression. Although TNF-alpha has benefits in the early stages of wound healing, excessively high levels or a sustained inflammatory response can lead to problems, such as excessive scar tissue formation or blockages, which can impede the wound healing process. This study utilized the PRISMA-ScR (Scoping Review) protocol. A review was conducted of articles discussing the Role of TNF-Alpha in the Wound Healing Process: Molecular and Clinical Perspectives within the last 10 years. Literature search in this study using PubMed, ScienceDirect, Elsivier and Google Scolar databases Search using English, abstract and full text. After searching with the keywords: The Role of TNF-Alpha, 19,022 articles were found. The search continued using the keyword The Role of TNF-Alpha in the Wound Healing found 346 articles. The last search using the keyword The Role of TNF-Alpha in the Wound Healing: Molecular and Clinical found 26 articles. TNF-α plays an important role in the early stages of cutaneous wound healing, significantly delayed after day 3, but not by day 7. TNF-α has a crucial role in the early stages of skin wound healing, and its administration is recognized to have a positive impact on the healing response, which may pave the way for innovative strategies to address chronic skin wound healing problems.
A Recombinant DNA Technique in The Genetic Engineering of Insulin from Bacteria rahman, Khaidir Yusuf; Sanely; Defa Pratama; Ziske Maritska
Jurnal Riset Kedokteran Volume 3, No.2, Desember 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v3i2.2626

Abstract

Abstract. Human Growth and human insulin were the first proteins to be produced on an industrial scale. Methods: The research method used in this study was a clinical literature review on recombinant DNA techniques from insulin in bacteria from the review literature taken from Pubmed and SCopus, for further search and analysis with other existing research. Recombinant DNA technology comprises altering genetic material outside an organism to obtain enhanced and desired characteristics in living organisms or as their products. Two biosynthetic insulin analogs have sufficiently long duration of action for use as once-daily basal insulins. Some biosimilars have been developed to human insulins as produced by Lilly and NovoNordisk, but their use is more restricted given the problems encountered by the use of human insulin, see Dolinar et al for a recent review of the field. Several companies have developed or are developing depot preparations that can be administered one a week instead of once a day. Recombinant DNA technology is an important development in science that has made the human life much easier. The clinical effect of Growth hormone therapy in children can be best measured on an annual basis and compared with predicted adult height whereas failure to lower blood sugar can be seen immediately in insulin or insulin analogue therapy. Abstrak. Pertumbuhan Manusia dan insulin manusia adalah protein pertama yang diproduksi dalam skala industri. Metode penelitian yang digunakan dalam penelitian ini adalah tinjauan literatur klinis mengenai teknik DNA rekombinan dari insulin pada bakteri dari tinjauan literatur yang diambil dari Pubmed dan SCopus, untuk selanjutnya dicari dan dianalisis dengan penelitian lain yang sudah ada. Teknologi DNA rekombinan terdiri dari pengubahan materi genetik di luar suatu organisme untuk memperoleh karakteristik yang ditingkatkan dan diinginkan pada organisme hidup atau sebagai produknya. Dua analog insulin biosintetik mempunyai durasi kerja yang cukup lama untuk digunakan sebagai insulin basal sekali sehari. Beberapa biosimilar telah dikembangkan untuk insulin manusia seperti yang diproduksi oleh Lilly dan NovoNordisk, namun penggunaannya lebih dibatasi mengingat permasalahan yang dihadapi dalam penggunaan insulin manusia, lihat Dolinar dkk untuk tinjauan terbaru di lapangan. Beberapa perusahaan telah mengembangkan atau sedang mengembangkan persiapan depot yang dapat diberikan satu kali dalam seminggu, bukan sekali sehari. Teknologi DNA rekombinan merupakan perkembangan penting dalam ilmu pengetahuan yang telah membuat hidup manusia lebih mudah. Efek klinis terapi hormon pertumbuhan pada anak-anak paling baik diukur setiap tahun dan dibandingkan dengan prediksi tinggi badan orang dewasa, sedangkan kegagalan menurunkan gula darah dapat langsung terlihat pada terapi insulin atau analog insulin.
Pengaruh Terpenoid pada Bunga Telang (Clitoria Ternatea L.) dalam Proses Penyembuhan Luka: Tinjauan Literatur Yusuf, Khaidir Yusuf; Basir, Salni; Maritska, Ziske; Layal, Kamalia
Jurnal Integrasi Kesehatan dan Sains Vol 7, No 1 (2025): Jurnal Integrasi Kesehatan dan Sains (in progress)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v7i1.14251

Abstract

Luka terjadi ketika integritas jaringan terganggu akibat cedera atau pembedahan dan dapat dikelompokkan berdasarkan struktur, proses penyembuhan, dan waktu sembuh. Saat kulit terluka, tubuh merespons dengan menghentikan pendarahan melalui vasokonstriksi dan pembentukan gumpalan darah. Bunga telang merupakan tanaman obat tradisional yang dapat meningkatkan kesehatan kulit dan mendukung regenerasi jaringan berkat kandungan terpenoid sebagai komponen bioaktif. Terpenoid merupakan senyawa organik dengan berbagai fungsi yang berkontribusi signifikan terhadap khasiat penyembuhan. Senyawa ini memiliki berbagai efek biologis, seperti efek anti-inflamasi, antioksidan, dan antibakteri yang sangat penting untuk penyembuhan luka. Tinjaun literatur pada penelitian ini dengan menggunakan protokol PRISMA-ScR (Scoping Review). Ulasan dilakukan pada artikel yang membahas tentang pengaruh terpenoid dalam proses penyembuhan luka. Pencarian literatur menggunakan database PubMed, ScienceDirect, Google Scholar dan MDPI (Multidisciplinary Digital Publishing Institute).Artikel dalam bahasa Inggris dan Indonesia dengan rentang waktu sepuluh tahun terakhir. Didapatkan hasil empat artikel yang sesuai dengan kriteria penelitian. Simpulan penelitian ini adalah terpenoid dapat mempercepat proses penyembuhan luka dengan mendorong angiogenesis yang membantu aliran oksigen dan nutrisi ke area yang terluka. Selain mengurangi peradangan, terpenoid juga mendukung metabolisme sel yang terlibat dalam penyembuhan luka.The Role of Terpenoids in Butterfly Pea (Clitoria ternatea L.) in the Wound Healing Process: A Literature ReviewAbstractWounds occur when the integrity of the tissue is compromised due to injury or surgery and can be grouped based on structure, healing process, and healing time. When the skin is injured, the body responds by stopping bleeding through vasoconstriction and the formation of blood clots. Telang flower is a traditional medicinal plant that can improve skin health and support tissue regeneration thanks to the content of terpenoids as bioactive components. Terpenoids are organic compounds with various functions that contribute significantly to healing properties. These compounds have various biological effects, such as anti-inflammatory, antioxidant, and antibacterial effects essential for wound healing. The literature review in this study uses the PRISMA-ScR (Scoping Review) protocol. The review was conducted in an article that discusses the influence of terpenoids in the wound-healing process. A literature search was conducted, and articles published in PubMed, ScienceDirect, Google Scholar, and MDPI (Multidisciplinary Digital Publishing Institute) were used. Articles in English and Indonesian have been published for the last ten years. The results of four articles were obtained following the research criteria. This study concludes that terpenoids can speed up the wound-healing process by promoting angiogenesis, which helps flow oxygen and nutrients to the injured area. In addition to reducing inflammation, terpenoids also support the metabolism of cells involved in wound healing.
Efek Sitokin Proinflamasi TnF - Alpha pada Penyakit Diabetes Melitus Tipe 2: Tinjauan Literatur Yusuf, Khaidir; Legiran, Legiran
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 1 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i1.12780

Abstract

Tumor necrosis factor alpha (TNF-α) salah satu mediator proinflamasi terpenting yang secara kritis terlibat dalam perkembangan resistensi insulin dan patogenesis diabetes melitus tipe II (T2DM). Peningkatan kadar TNF-α menginduksi resistensi insulin pada adiposit dan jaringan perifer. Tinjaun literatur pada penelitian ini menggunakan database PubMed dan Science direct terhadap artikel yang membahas TNF-alpha pada diabetes melitus tipe 2 dalam 5–10 tahun terakhir. Kata kunci dicari dengan satu kata atau dikombinasikan dengan kata kunci lainnya. Penyaringan dilakukan dari artikel berbahasa inggris. Tnf-alpha dan penyakit diabetes melitus tipe 2 ada keterkaitan. Pada literatur dikatakan patogenesis diabetes mellitus tipe 2 (DMT2) dan perkembangan resistensi insulin ditandai oleh beberapa faktor stimulasi, terutama pembentukan spesies oksigen reaktif (ROS) dan peningkatan berbagai sitokin pro-inflamasi. Tumor necrosis factor-alpha (TNF-α) adalah salah satu mediator proinflamasi terpenting yang terlibat dalam perkembangan resistensi insulin dan patogenesis T2DM. Tumor necrosis factor-α (TNF-α) terlibat dalam banyak patologi manusia, termasuk penyakit autoimun, resistensi insulin terkait obesitas, komplikasi kardiovaskular dan kanker, serta berperan terjadi peradangan kronis pada ginjal yang merupakan bentuk komplikasi diabetes tipe 2. Pada penelitian lain juga menguatkan pendapat peneliti dijelaskan bahwa efek sitokin pro inflamasi dan anti-inflamasi (TNF-a) dapat mengganggu jalur persinyalan insulin sehingga menyebabkan resitensi insulin pada sel B-pancreas. Simpulan penelitian ini adalah TNF-α menyebabkan resistensi insulin dan menyebabkan seseorang menderita diabetes melitus tipe 2. Tumor necrosis factor-alpha (TNF-α) is one of the most crucial proinflammatory mediators critically involved in the development of insulin resistance and the pathogenesis of type 2 diabetes mellitus (T2DM). Elevated levels of TNF-α induce insulin resistance in adipocytes and peripheral tissues. A literature review was conducted using databases such as PubMed and Science direct to explore articles discussing TNF-Alpha in type 2 diabetes over the past 5–10 years. Keywords were searched individually or in combination with others, and articles in English were screened. The literature reveals a connection between TNF-alpha and type 2 diabetes mellitus. The pathogenesis of type 2 diabetes mellitus (T2DM) and the development of insulin resistance are characterized by various stimulating factors, particularly the formation of reactive oxygen species (ROS) and an increase in various pro-inflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is identified as one of the key proinflammatory mediators involved in insulin resistance development and T2DM pathogenesis. TNF-α is implicated in various human pathologies, including autoimmune diseases, obesity-related insulin resistance, cardiovascular complications, cancer, and plays a role in the occurrence of chronic inflammation in the kidneys, a form of complication in type 2 diabetes. Other studies support the notion that the effects of pro-inflammatory and anti-inflammatory cytokines (TNF-α) can disrupt insulin signaling pathways, leading to insulin resistance in pancreatic B cells. In conclusion, this research indicates that Tumor necrosis factor-alpha (TNF-α) can induce insulin resistance, contributing to the onset of type 2 diabetes.
Co-Authors Basir, Salni Defa Pratama Layal, Kamalia Legiran Legiran Sanely Ziske Maritska