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All Journal Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Pharmaqueous Jurnal Tumbuhan Obat Indonesia
Indratmoko , Septiana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Tablet Ekstrak Metanol Buah Bakau Hitam (Rhizophora Mucronata): Formulasi, Uji Sifat Fisik Dan Uji Antioksidan Septiana Indratmoko; Rochany Septiyaningsih
Pharmaqueous : Jurnal Ilmiah Kefarmasian Vol. 5 No. 1 (2023): Volume 5. Nomor 1, Mei 2023
Publisher : Prodi S1 Farmasi, Universitas Al Irsyad Al Islamiyyah Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v5i1.468

Abstract

Ekstrak buah bakau hitam (Rhizophora mucronata) memiliki kandungan senyawa flavonoid, hidroquinon, triterpenoid, tanin, dan saponin. Flavonoid diketahui memiliki aktivitas antioksidan, Tujuan dari penelitian ini yaitu untuk mengetahui formulasi yang tepat untuk sediaan tablet, mengetahui hasil evaluasi stabilitas sediaan tablet, mengetahui aktivitas antioksidan pada sediaan tablet ekstrak buah bakau rhizophora mucronata. Formulasi terbaik dihasilkan oleh formulasi 1 dengan komposisi bahan ekstrak metanol buah bakau rhizophora mucronata 10 mg, larutan PVP 5%, Mg stearat 1%, SSG 2%, avicel 10%, laktosa ad 500 mg. Hasil dari uji granul didapatkan waktu alir rata – rata selama 6.56 detik, sudut diam 24,68o, indeks pemampatan 6,52%. keseragaman bobot teblet dengan nilai CV 2,06%, kekerasan tablet 7,36 kg/cm2, waktu hancur tablet 14.13 menit, kerapuhan tablet 0,71%. Aktivitas antioksidan tablet menggunakan DPPH dengan nilai IC50 sebesar 150,52 μg/mL bersifat lemah.
HUBUNGAN PENGETAHUAN DAN SIKAP REMAJA TENTANG UPAYA PENCEGAHAN HIV/AIDS Rochany Septiyaningsih; Dhiah Dwi Kusumawati; Septiana Indratmoko
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 8, No 1 (2023)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v8i1.198

Abstract

Remaja merupakan kelompok beresiko untuk penularan HIV/AIDS, karena masa remaja adalah masa individu berada pada mobilitas sosial yang paling tinggi karena akan membuka peluang baginya untuk terpapar terhadap berbagai perubahan sosial, kultural, budaya, serta fisik maupun psikologis. Hal itu membuat remaja tersebut mempunyai kerentanan yang tinggi terhadap penularan berbagai jenis penyakit salah satunya HIV/AIDS. Faktor penyebab adalah kurangnya pengetahuan tentang HIV/AIDS. Pengetahuan tentang HIV/AIDS sangat mempengaruhi sikap untuk melakukan tindakan pencegahan HIV/AIDS. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara pengetahuan dan sikap remaja tentang upaya pencegahan HIV/AIDS. Metode penelitian ini menggunakan analitik korelasional dengan pendekatan cross sectional dengan teknik accidental sampling yang berjumlah 30 responden. Analisis bivariat menggunakan uji Chi Square. Hasil penelitian: menunjukkan bahwa ada hubungan antara pengetahuan dan sikap remaja tentang upaya pencegahan HIV/AIDS, nilai sig 0,024 (
Optimasi Formula Nanohydrogel Icariin Sebagai Afrodisiak.: Optimization of Icariin Nanohydrogel Formula as an Aphrodisiac Tajudin, Tatang; Indratmoko , Septiana; Prawatya, Adecya Nur
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.998

Abstract

Decreased sexual desire is a type of sexual dysfunction that is common in men. Sexual dysfunction can be controlled by using herbs that have activity as aphrodisiacs. Many herbs are efficacious as aphrodisiacs, one of which is the icariin compound from the epimedium plant. However, the use of oral drugs must go through absorption and distribution processes to cause pharmacological effects, besides that the first pass effect that occurs in the liver reduces the bioavailability of the drug. This study aims to optimize the icariin nanohydrogel formula for use as a topical aphrodisiac, preparation characteristics, and the effect of nanohydrogel on the diffusion of icariin compounds. Formula optimization was carried out using the Simplex Latice Design (SLD) method with variations of carbopol, HPMC and TEA. Quantitative data analysis of aphrodisiac activity was analyzed by One Sample T-Test. The optimal formulation is obtained at a ratio of 1.415 (carbopol) : 2.168 (HPMC) : 1.208 (TEA), resulting in a clear, cucumber fish oil-scented preparation that is stable, with a viscosity of 19753.3 cps and an adhesive force of 0.387 seconds, pH 6.1, as well as a spreading power with a diameter of 5.56 cm. The hedonic test conducted on 4 formulas with the addition of fragrance shows that formula 3 is preferred by the respondents, followed by formula 4, formula 2, and formula 1. The cumulative amount of the penetrated preparation is 0,174 µg/cm2 at 10 minutes, 0,283 µg/cm2 at 15 minutes, 0,398 µg/cm2 at 30 minutes, 0,498 µg/cm2 at 60 minutes, and 0,603 µg/cm2 at 120 minutes.
Optimasi Formula Nanohydrogel Icariin Sebagai Afrodisiak.: Optimization of Icariin Nanohydrogel Formula as an Aphrodisiac Tajudin, Tatang; Indratmoko , Septiana; Prawatya, Adecya Nur
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.998

Abstract

Decreased sexual desire is a type of sexual dysfunction that is common in men. Sexual dysfunction can be controlled by using herbs that have activity as aphrodisiacs. Many herbs are efficacious as aphrodisiacs, one of which is the icariin compound from the epimedium plant. However, the use of oral drugs must go through absorption and distribution processes to cause pharmacological effects, besides that the first pass effect that occurs in the liver reduces the bioavailability of the drug. This study aims to optimize the icariin nanohydrogel formula for use as a topical aphrodisiac, preparation characteristics, and the effect of nanohydrogel on the diffusion of icariin compounds. Formula optimization was carried out using the Simplex Latice Design (SLD) method with variations of carbopol, HPMC and TEA. Quantitative data analysis of aphrodisiac activity was analyzed by One Sample T-Test. The optimal formulation is obtained at a ratio of 1.415 (carbopol) : 2.168 (HPMC) : 1.208 (TEA), resulting in a clear, cucumber fish oil-scented preparation that is stable, with a viscosity of 19753.3 cps and an adhesive force of 0.387 seconds, pH 6.1, as well as a spreading power with a diameter of 5.56 cm. The hedonic test conducted on 4 formulas with the addition of fragrance shows that formula 3 is preferred by the respondents, followed by formula 4, formula 2, and formula 1. The cumulative amount of the penetrated preparation is 0,174 µg/cm2 at 10 minutes, 0,283 µg/cm2 at 15 minutes, 0,398 µg/cm2 at 30 minutes, 0,498 µg/cm2 at 60 minutes, and 0,603 µg/cm2 at 120 minutes.
Co-Authors Dhiah Dwi Kusumawati Prawatya, Adecya Nur Rochany Septiyaningsih Rochany Septiyaningsih Tajudin, Tatang