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All Journal Indonesia Chimica Acta Jurnal Kesehatan Prima Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Nur Indra, Asep Iin
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Extraction Of Brazilin From Sappan Wood as a Natural Reagent for Borax Detection by Digital Imaging Analysis Rismiarti, Zuri; Rahmat, Mamat; Nur Indra, Asep Iin; Syaindi, Amanda Afifah
Jurnal Kesehatan Prima Vol 18, No 2 (2024): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v18i2.1440

Abstract

The use of brazilien for borax detection is because the chemical properties of this compound are greatly influenced by pH which results in a change in the color of the brazilien. This compound gives an orange color at a pH range of 6-7 and yellow at an acidic pH, while at a pH range of 7-10 it gives a red color and at a pH >10 it gives a purplish red color. This research uses Brazilian extract from sappan wood for borax detection. By utilizing this compound extract, the use of chemical reagents for the detection of borax in food samples can be minimized. Apart from that, it can increase the added value of these crop commodities and can take advantage of the abundant natural resources in Indonesia. This research aims to develop a method that is accurate, simple and cheap and does not use special instruments to diagnose borax based on digital imaging, which includes extraction of brazilien from sappan wood using a maceration method using 96% ethanol solvent and water with a UV-Vis spectrophotometer, ratio optimization brazilin extract with boric acid, optimization of measurement time. The results of the research show that the solvent that provides optimum absorbance for brazilin extraction is water or distilled water, with a ratio of brazilin extract and boric acid of 1:1 and the measurement time is 5 minutes.
Development of a Multi-epitope Vaccine against Mycobacterium tuberculosis DNA Protein B: An Immunoinformatics-Driven Strategy Nur Indra, Asep Iin; Ashari, Fatkhurrohmah; Aprilia, Keisha Nur Gita; Anggraeni, Putri; Silaban, Veronika Desmita; Widiatmoko, Egi Gussuma
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.41408

Abstract

Vaccination is a primary strategy in the prevention of tuberculosis (TB), a serious infectious disease caused by Mycobacterium tuberculosis. This study aims to design a novel multiepitope vaccine using the DNA B protein from M. tuberculosis through immunoinformatics and molecular dynamics approaches. The design process begins with the identification of potential epitopes from the DNA B protein using various bioinformatics tools to predict both B and T cell epitopes based on their immunogenic properties. After epitope identification, the selected epitopes are combined into a multiepitope vaccine construct to enhance a broad and specific immune response. The three-dimensional structural model of the vaccine construct is predicted and validated using molecular modeling techniques. Molecular dynamics simulations are performed to evaluate the stability and interactions between the multiepitope vaccine and the immune system, providing insights into the expected immune response. Simulation analysis indicates that the vaccine construct is stable and capable of eliciting a strong immune response. In silico testing was conducted to predict the vaccine's affinity for Major Histocompatibility Complex (MHC) receptors and its ability to induce T and B cell immune responses. The results of this analysis demonstrate that the designed multiepitope vaccine has high potential to trigger an effective immune response against Mycobacterium tuberculosis. This study provides a solid foundation for further development and evaluation of the vaccine in in vivo studies to determine its clinical safety and efficacy
EFEK INFUSUM DAUN KENIKIR (Cosmos caudatus) TERHADAP PERUBAHAN MORFOLOGI DAN TINGKAT KEMATIAN LARVA Aedes aegypti Nur Indra, Asep Iin; Rahmat, Mamat; Sulaeman, Sulaeman; Rohayati, Rohayati; Sufa, Hafizah Ilmi
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 2 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i2.2776

Abstract

Dengue fever is a serious health problem in Indonesia, caused by the Aedes aegypti mosquito. Mosquito resistance to chemical insecticides is increasing due to inappropriate use, so alternative vector control is needed, including natural larvicides from plants. Kenikir (Cosmos caudatus) is one of the plants that has potential as a larvicide, thanks to its essential oil and secondary metabolites. This study aims to test the effect of kenikir leaf infusion on the mortality of Aedes aegypti larvae with various concentrations and determine the effective concentration as LC50, which kills 50% of larvae. The population in this study was all species of kenikir from Manoko plantation, Lembang, with the sample being the leaves of Cosmos caudatus species. A total of 315 Aedes aegypti larvae were obtained from Loka Litbang and used as research objects. A true experimental method was used with a Static Group Comparison design, involving experimental and control groups. The object of the study was Aedes aegypti instar III larvae tested with kenikir infusion at concentrations of 25%, 35%, 45%, 55%, and 65%. The results showed that the minimum effective concentration was 25%, while the probit test indicated a concentration of 28% as the LC50 in 24 hours. Larval mortality was caused by damage to the outer membrane of the tissue, indicating an effect of the kenikir extract, rather than a lack of food.
Co-Authors Aprilia, Keisha Nur Gita Ashari, Fatkhurrohmah Mamat Rahmat Putri Anggraeni rohayati rohayati Silaban, Veronika Desmita Sufa, Hafizah Ilmi Sulaeman Sulaeman Syaindi, Amanda Afifah Widiatmoko, Egi Gussuma Zuri Rismiarti