Albright, Ivan Angelo
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Risk Factor of Dietary Habit with Cholelithiasis Lysandra, Annora Zerlina; Putri Wairooy, Nabilah Azzah; Ifadha, Rania Tasya; Ramainaldo S., Adra Achirultan; Albright, Ivan Angelo; Izzah, Alifah Fajriyyatul; Rahma M., Viky Nafi'ah; Lestari, Pudji
Journal of Community Medicine and Public Health Research Vol. 3 No. 1 (2022): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.507 KB) | DOI: 10.20473/jcmphr.v3i1.27931

Abstract

Cholelithiasis affects 10-15% of the adult population. There are four main factors commonly associated with cholelithiasis abbreviated as "4F''namely female, forty, fertile and fat. However, the relationship between dietary habits as a risk factor of cholelithiasis has not been explained. The aim of the study was to determine the association between dietary habits and cholelithiasis. This study used a systematic review design with a comprehensive search of PubMed, Scopus, ScienceDirect, SpringerLink, and SAGE published from 2017 to 2021. Five studies (three prospective cohorts and two case-control studies) were included. The overall analysis of studies reported a significant risk factor of cholelithiasis in high intake of animal fats, meat, and fried foods and significant protection against cholelithiasis in high intake of fruits, nuts, fish, MUFA/SFA, n-3 FA/omega-3 fatty acids, and vegetables. Healthy dietary habits characterized by high intake in vegetables, fruits, fish, MUFA/SFA, n-3 FA/omega-3 fatty acids, and nuts will lower the risk of cholelithiasis.
Chronic inflammation and gut microbiota at a glance: Insights into fertility barriers Winarno, Bondan; Albright, Ivan Angelo; Tjahyono, Evi; Adamas, Muhammad; Poli, Januar Alfred; Supardi, Supardi
Indonesian Andrology and Biomedical Journal Vol. 5 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i2.66098

Abstract

The acrosome reaction (AR) is a crucial step in fertilization, enabling sperm to penetrate the oocyte's protective layers, but various elements can hinder AR. Fertilization is a fundamental process in mammalian reproduction, involving the fusion of a sperm with oocyte. To achieve this, sperm must undergo capacitation, a series of biochemical changes that prepare them for fertilization. Once capacitated, sperm can penetrate the protective layers of the oocyte, after capacitation, sperm bind to receptors on the zona pellucida (ZP), a protective layer surrounding the egg. This binding triggers the acrosome reaction (AR), releasing enzymes that help the sperm penetrate the protective layers. Once the sperm has penetrated, it fuses with the oocyte's plasma membrane, delivering its genetic material. Anti-sperm antibodies (ASA) can directly bind to sperm, hindering their function and ability to undergo AR. Chronic inflammation, often associated with conditions like diabetes and obesity, with chronic hyperglycemia producing advanced glycation end products (AGEs) can create a pro-inflammatory environment that negatively impacts sperm parameter and function. Additionally, gut microbiota (GM) dysbiosis has been linked to chronic inflammation and may contribute to infertility. Proper AR is essential for successful fertilization, but presence of ASA, GM dysbiosis, and chronic inflammation may hinder fertility. The evidence suggests improving inflammation by proper GM symbiosis may improve sperm parameter and fertility.