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All Journal Journal of Dentistry Indonesia Medical and Health Journal
Amalia, Rahma Ika
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Dentistry Medicine & Pharmacology

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MANIFESTASI ORAL PADA PASIEN DIABETES MELLITUS Prakosa, Aditya Priagung; Aliyyu, Wienda Cinta; Rosyadah, Nada Janardita; Nur, Saniyya; Amalia, Rahma Ika
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8891

Abstract

Diabetes melitus termasuk dalam penyakit tidak menular yang kronis disebabkan oleh gangguan metabolisme di organ pankreas ditandai dengan peningkatan kadar gula darah melebihi normal. Wilayah Asia Tenggara yang didalamnya temasuk negara Indonesia menempati peringkat ke-3 di dunia dengan prevalensi penderita diabetes melitus mencapai 11.3%. Sementara itu, Indonesia menempati peringkat ke-7 di antara 10 negara dengan penderita diabetes melitus terbanyak mencapai 10,7 jiwa. Diabetes melitus dapat bermanifestasi menjadi penyakit lain salah satunya kelainan-kelainan di rongga mulut. Bentuk manifestasi diabetes melitus di rongga mulut yang umum ditemui antara lain, Oral Infection (Candidiasis), Xerostomia, Penyakit Periodontal, Recurrent Dental Caries, Burning mouth sensation (berkaitandengan xerostomia), Taste Dysfunction, Oral Mucosa Alteration (Lichen Planus), Poor Oral Wound Healing. Dalam tinjauan literatur ini menjelaskan mengenai penyakit sistemik diabetes melitus, pemeriksaan penunjang diagnosis dan tatalaksana manifestasi oral diabetes melitus. Tatalaksana manifestasi oral diabetes melitus tidak hanya berfokus pada penanganan penyakit yang ada di rongga mulut, namun lebih diutamakan untuk menghilangkan faktor etiologi serta menghindari faktor predisposisi.
Effectiveness of Mucoadhesive Patch Clitoria Ternatea Extract in Wound Healing Process After Tooth Extraction in Sprague Dawley Rats Amalia, Rahma Ika; Prastiya, Wahyu; Meirawati, Nur; Hirawan, Helmi; Sari, Dwi Nur Indah
Journal of Dentistry Indonesia Vol. 31, No. 3
Publisher : UI Scholars Hub

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Abstract

Objective: This study aims to evaluate the effectiveness of mucoadhesive patch clitoria ternatea extract for wound healing post-tooth extraction. Methods: The research was carried out experimentally in a laboratory. 30 Sprague Dawley rats were selected and randomly divided into mucoadhesive patch clitoria ternatea (MPCT) 5%, 10%, 15%, positive and negative control groups. The upper incisors of rats were extracted and treated once a day for 7 and 14 days. Wound healing was observed based on histological observation (fibroblasts, collagen density, and epithelial thickness). Data was analyzed statistically. Results: MPCT 15% applied for 14 days showed the highest number of fibroblasts, collagen density, and epithelial thickness among all groups and was significantly different compared to the positive control and negative control (p < 0.05). Conclusion: Mucoadhesive patch clitoria ternatea extract was effective in the wound healing process after tooth extraction, with the most effective concentration is 15%.
Co-Authors Aliyyu, Wienda Cinta Dwi Nur Indah Sari Hirawan, Helmi Meirawati, Nur Nur, Saniyya Prakosa, Aditya Priagung Prastiya, Wahyu Rosyadah, Nada Janardita