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All Journal Majalah Obstetri dan Ginekologi Diponegoro International Medical Journal (DIMJ)
Kristiawan, Endy Cahyono
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Health Professions Medicine & Pharmacology Neuroscience

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Incidence of radiation proctitis in cervical cancer receiving radiation therapy at Dr. Kariadi Hospital, Semarang, Indonesia Mirza Iskandar, Teuku; Kristiawan, Endy Cahyono; Faizal, Teuku Rendiza; Ambari, Ediwibowo; Putra, Very Great Eka; Achmad, Lubena
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.123-128

Abstract

HIGHLIGHTS Radiation proctitis is a post-radiotherapy concern, urging research to reduce its occurrence and improve the well-being of patients. Radiotherapy is the primary treatment for advanced cervical cancer, offering hope and preserving quality of life for patients.   ABSTRACT Objective: To determine the incidence of radiation proctitis in cervical cancer patients after radiation at Dr. Kariadi Hospital, Semarang, Indonesia. Materials and Methods: A descriptive analytic study on 356 cervical cancer patients who received radiation therapy at Dr. Kariadi Hospital Semarang from January 2017 to December 2018 who met the inclusion criteria. Factors assessed included age, BMI, hematologic, stage, histopathology, history of radical hysterectomy surgery and duration of radiation. Cervical cancer staging was assessed using FIGO 2018. Statistical analysis was performed using Mann Whitney with a significant value of p <0.05. Results: From the Chi-square analysis, the relationship between radiation period (less than 56 days and more than 56 days)  (p=0.164), the relationship between age ≥45 and the incidence of proctitis (p=0.208), BMI ≥25 and the incidence of proctitis (p=0.838), Hb <10 with the incidence of proctitis (p=0.492), parity ≤1 with the incidence of proctitis (p=0.137), the relationship between the histopathological examination results with the incidence of proctitis (p=0.253), and stage level with the incidence of proctitis (p=0.226) were not significant. The highest incidence of proctitis occurred in stage 3B of the cervical cancer patients (14.5%). Conclusion: The prevalence of proctitis in cervical cancer patients for the period 2017-2018 was 15.4%. Age, histopathological appearance, stage, history of anemia, history of radical surgery and appearance of symptoms after surgery with symptoms of proctitis did not show a significant relationship.
Bacteria Patterns and Antibiotic Sensitivities in Patients with Preterm Premature Rupture of Membrane: Study of Patients with PPROM ≤ 6 Hours And > 6 Hours at General Hospital Kariadi Semarang Munthe, Rio Bornfry Haro; Pramono, Besari Adi; Kristiawan, Endy Cahyono; Poerwoko, Agoes Oerip; Cahyanti, Ratnasari Dwi
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.24649

Abstract

Background: Preterm premature rupture of membranes (PPROM) has multifactorial causes. Ascending bacterial invasion can cause intrauterine infection in up to 60% of cases with PPROM. Giving antibiotics at inadequate concentrations causes bacteria to grow exponentially, which is characterized by very fast growth.Objective: This study aims to determine bacteria patterns and antibiotic sensitivity in patients with PPROM at Dr. RSUP. Kariadi, Semarang.Methods: Observational analytical research with a cross-sectional design. The research subjects were 46 pregnant women aged 20-36 weeks 6 days who experienced PPROM. The selection of research subjects was carried out using the consecutive sampling method, namely the selection of research subjects based on research criteria and the subjects signed an agreement to participate in the research. The independent variables in this study were preterm PPROM ≤ 6 hours and > 6 hours, the dependent variables in this study were bacteria patterns and antibiotic sensitivity. The data that has been obtained is analyzed using the SPSS program. Results are significant if p<0.05.Results: Escherichia coli and Candida albicans are the most found pathogens. The antibiotics vancomycin, meropenem, and amphotericin B are effective in patients with PPROM. Women who experienced PPROM ≤ 6 hours and > 6 hours did not have significant differences in bacteria patterns and antibiotic sensitivity results.Conclusion: The gram-negative rod-shaped bacteria Escherichia coli and the fungus Candida albicans are the main pathogens that cause PPROM. The administration of vancomycin, meropenem, and amphotericin B has high effectiveness in PPROM patients at RSUP dr. Kariadi Semarang.
Co-Authors Achmad, Lubena Agoes Oerip Poerwoko Besari Adi Pramono Ediwibowo Ambari Faizal, Teuku Rendiza Mirza Iskandar, Teuku Munthe, Rio Bornfry Haro Putra, Very Great Eka Ratnasari Dwi Cahyanti, Ratnasari Dwi