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All Journal Journal of Biomedicine and Translational Research Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Medica Hospitalia Diponegoro International Medical Journal (DIMJ)
Ediwibowo Ambari
Faculty of Medicine University of Diponegoro
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemotherapy Regiment PVB in Cervical Cancer Stage IB-IIA Ambari, Ediwibowo
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.064 KB)

Abstract

Objectives: To determine the factors that may be used as the prognostic parameter for the therapeutic efficacy of neoadjuvant chemotherapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was conducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions’ size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The patients’ response would be evaluated after completing 3 series of chemotherapy. Data was retrieved from medical records and cervical biopsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis. Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy before administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26). Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy. [Indones J Obstet Gynecol 2013; 1-3: 156-60] Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy
Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemotherapy Regiment PVB in Cervical Cancer Stage IB-IIA Ambari, Ediwibowo; Winarto, Hariyono; Sutrisna, Bambang; Siregar, Budiningsih
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.064 KB) | DOI: 10.32771/inajog.v1i3.357

Abstract

Objectives: To determine the factors that may be used as the prognostic parameter for the therapeutic efficacy of neoadjuvant chemotherapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was conducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions’ size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The patients’ response would be evaluated after completing 3 series of chemotherapy. Data was retrieved from medical records and cervical biopsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis. Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy before administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26). Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy. [Indones J Obstet Gynecol 2013; 1-3: 156-60] Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy
Squamous Cell Carcinoma Cervical Uterine Metastasis in Abdominal Wall: A Rare Case Report Cahyono, Endy; Iskandar, Teuku Mirza; Ambari, Ediwibowo; Eka Putra, Very Great; Lubena, Lubena; Wijaya, Dibyo Mukti
Journal of Biomedicine and Translational Research Vol 10, No 1 (2024): April 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i1.19668

Abstract

ABSTRACTBackground: About 80% of cervical cancers are squamous cell carcinomas. After severe surgery for squamous cervical cancer, abdominal metastasis is an uncommon occurrence.Case Presentation: A 33-year-old lady was diagnosed with cervical cancer and had a radical hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymphadenectomy. The histopathological examination showed non-keratinizing squamous cell carcinoma moderately differentiated. A 6 cm suggestive metastatic mass from abdominal region came up three months later after the surgery. An abdominal wall reconstruction surgery was conducted as the treatment for the metastasis mass.Conclusion: The best course of treatment for cervical cancer is still unknown due to the rarity of abdominal metastases. Depending on the severity of the illness and the existence of metastases, each patient receives a unique course of treatment.Keywords: squamous cell carcinoma, hysterectomy, cervical malignancies
Karsinoma Ovarii Serosa pada Kehamilan dengan Komplikasi IUGR : Laporan Kasus di RSUP Dr. Kariadi, Semarang Hapsari, Anggiyasti Vidya; Ambari, Ediwibowo; Dewantiningrum, Julian; Ushan, Ery Perdana
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.943 KB) | DOI: 10.36408/mhjcm.v7i1.436

Abstract

Karsinoma ovarium merupakan keganasan ginekologi terbanyak kedua yang terjadi pada kehamilan. Dilaporkan terjadi 1:10.000 sampai 1:25.000 kehamilan. Histopatologi karsinoma ovarium jenis epitelial lebih jarang terjadi dibandingkan germ cell tumor1,2. Kehamilan tidak mempengaruhi prognosis karsinoma ovarium, akan tetapi komplikasi yang mungkin terjadi adalah torsi tumor, ruptur dan meningkatkan kemungkinan terjadinya persalinan prematur16. Tulisan ini melaporkan seorang wanita, 31 tahun, primigravida, hamil 34 minggu, dengan pembesaran abdomen melebihi usia kehamilan, peningkatan kadar Ca-125 darah dan massa solid ovarium sinistra disertai ascites pada pemeriksaan ultrasonografi. Pemeriksaan histopatologi jaringan tumor ovarium, uterus dan omentum menunjukkan diagnosis low grade serous carcinoma ovarii bilateral dengan infiltrasi hingga tuba dan omentum. Pemeriksaan rutin kehamilan dengan ultrasonografi penting dilakukan untuk skrining adanya neoplasma ovarium yang menyertai kehamilan. Penatalaksanaan hamil dengan tumor padat ovarium tergantung dari usia kehamilan. Menurut algoritme dilakukan operasi pengangkatan massa dan dilakukan frozen section (FS) untuk mengetahui sifat tumor jinak atau ganas pada usia kehamilan 18-22 minggu dan dilanjutkan dengan operasi lanjutan setelah kelahiran bayi16. Pada kasus ini dengan mempertimbangkan kehamilan ini merupakan kehamilan pertama dengan tidak adanya keluhan dan secara prinsip tidak adanya perubahan anatomi untuk dapat dilakukan operasi complete surgical staging saat bayi dilahirkan pada usia kehamilan 34 minggu, maka dari hasil rapat medis diambil keputusan untuk dilakukan operasi complete surgical staging bersamaan setelah sectio caesaria. Prosedur operasi ini tidak mudah dilakukan dan banyak dihindari, tetapi dengan kehati-hatian dan identifikasi struktur anatomi yang baik, maka operasi berjalan lancar.
Incidence of radiation proctitis in cervical cancer receiving radiation therapy at Dr. Kariadi Hospital, Semarang, Indonesia Mirza Iskandar, Teuku; Kristiawan, Endy Cahyono; Faizal, Teuku Rendiza; Ambari, Ediwibowo; Putra, Very Great Eka; Achmad, Lubena
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.123-128

Abstract

HIGHLIGHTS Radiation proctitis is a post-radiotherapy concern, urging research to reduce its occurrence and improve the well-being of patients. Radiotherapy is the primary treatment for advanced cervical cancer, offering hope and preserving quality of life for patients.   ABSTRACT Objective: To determine the incidence of radiation proctitis in cervical cancer patients after radiation at Dr. Kariadi Hospital, Semarang, Indonesia. Materials and Methods: A descriptive analytic study on 356 cervical cancer patients who received radiation therapy at Dr. Kariadi Hospital Semarang from January 2017 to December 2018 who met the inclusion criteria. Factors assessed included age, BMI, hematologic, stage, histopathology, history of radical hysterectomy surgery and duration of radiation. Cervical cancer staging was assessed using FIGO 2018. Statistical analysis was performed using Mann Whitney with a significant value of p <0.05. Results: From the Chi-square analysis, the relationship between radiation period (less than 56 days and more than 56 days)  (p=0.164), the relationship between age ≥45 and the incidence of proctitis (p=0.208), BMI ≥25 and the incidence of proctitis (p=0.838), Hb <10 with the incidence of proctitis (p=0.492), parity ≤1 with the incidence of proctitis (p=0.137), the relationship between the histopathological examination results with the incidence of proctitis (p=0.253), and stage level with the incidence of proctitis (p=0.226) were not significant. The highest incidence of proctitis occurred in stage 3B of the cervical cancer patients (14.5%). Conclusion: The prevalence of proctitis in cervical cancer patients for the period 2017-2018 was 15.4%. Age, histopathological appearance, stage, history of anemia, history of radical surgery and appearance of symptoms after surgery with symptoms of proctitis did not show a significant relationship.
Factors Associated With Recurrence Of Epithelial Ovarian Cancer In RSUP Dr. Kariadi Semarang Kurube, Isabela Marsialina; Ambari, Ediwibowo; Iskandar, Teuku Mirza; Tjahjanto, Hary; Dewantiningrum, Julian; Mochtar, Arufiadi Anityo; Trisetiyono, Yuli
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15448

Abstract

Introductions: Epithelial ovarian cancer accounts for 90% of all ovarian malignancies. More than 70% of patients will experience a relapse even after receiving operative therapy and chemotherapy. There are several prognostic factors that influence the recurrence of ovarian cancer. In Indonesia, especially at Dr. Kariadi Hospital, Semarang, the data as mentioned above is still very limited.objective: Knowing the disease-free survival rate, optimizing surgery and factors related to the incidence of recurrence in epithelial ovarian cancer patients at Dr. Kariadi Hospital SemarangMethods: This study is a retrospective cohort study with survival analysis. Data were collected through medical records, with the study population are patients with a diagnosis of epithelial ovarian cancer who were treated at Dr. Kariadi Hospital Semarang in period January 2018-December 2019. Furthermore, patients who had been remission were observed for signs of disease recurrence for 2 years period.Results: There were 361 patients with epithelial ovarian cancer who underwent primary treatment at Dr. Kariadi Hospital, Semarang in  2018-2019. Furthermore, there were observations of recurrence in 148 patients who achieved remission. Of these 76 patients (51.4%) experienced recurrence, while 72 patients not relapse. From 148 epithelial ovarian cancer patients who underwent cytoreduction surgery at Dr. Kariadi Hospital, Semarang, 113 patients (76.4%) achieved optimal operation with a residu less than 2 cm, while 35 patients (23.6%) were not optimal with a residu more than 2 cm. FIGO stage (HR 2.44) and tumor residu (HR 2.15) were shown to be significant factors associated with the recurrence of epithelial ovarian cancer.Conclusion: Overall disease-free survival in epithelial ovarian cancer at Dr. Kariadi Semarang were 74.8% (6 months), 57.1% (1 year), 42.5% (18 months), and 37.4% (2 years). Tumor residual factors and FIGO stage were shown to be significant prognostic factors influencing the recurrence of epithelial ovarian cancer. 
Co-Authors Achmad, Lubena Bambang Sutrisna Budiningsih Siregar Cahyono, Endy DIBYO MUKTI WIJAYA Eka Putra, Very Great Faizal, Teuku Rendiza Hapsari, Anggiyasti Vidya Hariyono Winarto Hary Tjahjanto Julian Dewantiningrum Kristiawan, Endy Cahyono Kurube, Isabela Marsialina Lubena Lubena, Lubena Mirza Iskandar, Teuku Mochtar, Arufiadi Anityo Putra, Very Great Eka Teuku Mirza Iskandar, Teuku Mirza Ushan, Ery Perdana Yuli Trisetiyono, Yuli