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Indah Sari, Dwi Nur
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Enhancement of mRNA Vascular Endothelial Growth Factor-A (VEGF-A) Induced Anemia in Oral Squamous Cell Carcinoma (OSCC) Ramadian, Kurnia Jelang; Mahardika, Choirumminanisa Imma; Pangastuti, Aliffala Widianaputri Setya; Ramadhani, Nabella Deby; Sulistyo, Hidayat; Widodo, Haris Budi; Indah Sari, Dwi Nur; Wardana, Tirta
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1278

Abstract

Background: Oral squamous cell carcinoma (OSCC) is a malignant epithelial neoplasm that can lead to mechanical disturbances and malnutrition, potentially causing anemia. Vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and vascularization, which may impact anemia in OSCC patients. This study aimed to investigate the differential mRNA expression of VEGF-A in OSCC patients with and without anemia.Method: This cross-sectional observational study analyzed 39 formalin-fixed paraffin-embedded (FFPE) samples from OSCC patients (13 with anemia, 26 without anemia). VEGF-A mRNA expression was quantified using qPCR with GAPDH as a reference gene. The Livak method was used to determine VEGF-A expression levels. Data were analyzed using GenEX MultiD 6.0 software, and statistical significance was assessed using independent T-tests. Results: VEGF-A mRNA expression in OSCC patients varied based on anemia status (1.94-fold), tumor size (1.44-fold), histological grade (1.21-fold), and anemia severity (1.30-fold). Significant differences in VEGF-A mRNA expression were observed for anemia status and tumor size (p 0.05), while histological grading and anemia severity showed no significant differences. Conclusion: This study demonstrates a significant difference in VEGF-A mRNA expression in OSCC patients with anemia, particularly in relation to tumor size. These findings contribute to our understanding of the relationship between VEGF-A expression and anemia in OSCC, potentially informing future diagnostic and therapeutic strategies.
Co-Authors Al Ghiffari, M. Iqbal Anisa, Rahmi Anisa, Uldri Haris Budi Widodo Hidayat Sulistyo Kaidah, Al Lubis, Muhammad Syahdifa Mahardika, Choirumminanisa Imma Manda, Mandataris Pangastuti, Aliffala Widianaputri Setya Pratama, M. Farkhan Putri, Nasywa Anindya Ramadhani, Nabella Deby Ramadian, Kurnia Jelang Saputra, Muhammad Rian Herman Sari, Vaula Nanda wardana, Tirta