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Obesity Current Research and Future Hope Rehan Haider; Asghar Mehdi; Geetha Kumari
Contemporary Journal of Applied Sciences Vol. 2 No. 2 (2024): February 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/cjas.v2i2.9573

Abstract

Obesity is a broad-based public health issue that is defined by excessive consumption of body fat, which is associated with more negative health impacts than positive ones, such as diabetes, cancer, and cardiovascular disease. This abstract backs up a brief overview of the approaches being used in the fight against obesity today and in the future.The goal of current research efforts is to comprehend the intricate interplay of behavioral, environmental, and historical factors that contribute to corpulence. Genetic research has uncovered a large number of vulnerable genes, removing the inherited components of obesity. In the meanwhile, material factors like fattening diets and indolent habits warrant more study.Approaches to behavior qualification and novel healing attacks are being energetically investigated. Strategies include expanding anti-corpulence medications, bariatric surgery, and targeting gut bacteria. In the areas of precision, treatment, customized digestive approvals, plant structure, and customized absorption, encouraging results are emerging.The integration of scientific and mathematical strength techniques holds the key to future success in the battle against obesity. Innovative approaches to tracking and managing obesity are provided by wearable technology, mobile devices, and telehealth manifestos. Healthcare providers and situations can benefit from the large dossier science of logical analysis and artificial intelligence in generating thoughtful remedies for individualized burden administration
Antitumor Necrosis Factor-α Drugs and Disease-Modifying Antirheumatic Drugs for Low Back Pain Rehan Haider; Asghar Mehdi
International Journal of Scientific Multidisciplinary Research Vol. 1 No. 11 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v1i11.6412

Abstract

The widespread and often debilitating ailment known as low back pain (LBP) is a significant worldwide energy concern. Despite its diversity, the pathophysiology of LBP is significant for attraction, incidence, and persistence. Currently, there is a growing interest in investigating the use of disease-modifying anti-rheumatic medicines (DMARDs) and anti-tumor necrosis factor-α (TNF-α) medications as prospective therapeutic alternatives for managing LBP, especially in cases where the angering component is evident. A proinflammatory cytokine called TNF-α is present in various chronic pain situations that entail LBP. TNF-α inhibitors, typically used secondary in conditions like rheumatoid arthritis, have been demonstrated to reduce pain and inflammation in people with low back pain. Similarly, DMARDs have been purposefully introduced due to their ability to alleviate LBP. They do this by harmonizing the invulnerable reaction and occupying antagonistic-instigative belongings. This abstract highlights the role of DMARDs and TNF-α inhibitors in the instigative component of the illness and describes how they work in the administration of LBP. This emphasizes how several learning approaches must be combined in order to administer LBP because these medications are guided by potential antagonistic possessions and embodied situation designs. It also discusses ongoing, objective issues and guidelines meant to provide evidence-based justifications for their application in LBP. Although DMARDs and TNF-α inhibitors show promise as LBP treatments, more study is needed to confirm their long-term safety and efficacy. As our comprehension of the intricate pathophysiology of LBP deepens, these pharmacological incursions allow us to improve useful approaches in comprehensive treatment of this contentious illness
The History of Diabetes Mellitus Rehan Haider; Asghar Mehdi
International Journal of Scientific Multidisciplinary Research Vol. 1 No. 10 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v1i10.6494

Abstract

Diabetes mellitus, an incessant metabolic disorder caused by increased blood glucose levels, has a rich and complex history spanning paradise. The first famous reference to diabetes dates back to ancient Egypt, where the condition was defined in healing texts around 1500 BCE. However, it was not just before the 19th century that important progress had been made in understanding and directing diabetes. In 1889, two German physicians, Joseph von Mering, and Oskar Minkowski, fashioned an important finding by professing that the removal of organ meat in dogs caused diabetes-like manifestations. This led to the identification of organ meat as an insulin source. In 1921, a Canadian group led by Frederick Banting and Charles Best released insulin, a birth control method that is critical for regulating glucose levels. This finding was obvious at a critical juncture in diabetes administration, as insulin injections have become a lifesaving situation for things associated with type 1 diabetes
Puerperium and Lactation: The Crucial Phases of Maternal and Infant Health Rehan Haider; Asghar Mehdi; Anjum Zehra
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 1 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i1.7026

Abstract

Puerperium and lactation are critical phases in a woman's life and are characterized by profound physiological and psychological changes. The puerperium, commonly known as the postpartum period, refers to the number of weeks following childbirth when a woman's body undergoes a series of adjustments to return to its non-pregnant state. This phase typically lasts for approximately six weeks but can vary from woman to woman. During puerperium, the uterus contracts, lochia (postpartum discharge) is expelled, and the body gradually recovers from the stress of pregnancy and childbirth. Emotional well-being is also an essential aspect of puerperium, as women often experience a range of emotions and adjustment challenges. Conversely, lactation is the process of producing and providing breast milk to the infants. It is a unique and essential aspect of motherhood, offering numerous health benefits for both the mother and baby. Lactation is primarily regulated by hormones, such as prolactin and oxytocin. Prolactin stimulates milk production, whereas oxytocin triggers milk ejection during breastfeeding. During lactation, the mother's body provides infants with vital nutrients, immunological protection, and emotional bonds through breastfeeding. This natural process also promotes uterine involution, helping the mother recover more quickly after childbirth. Furthermore, breastfeeding has far-reaching health benefits, reducing the risk of various diseases in both mothers and babies
Immunostimulants and Adaptogens from Plants Rehan Haider; Asghar Mehdi; Anjum Zehra; Geetha Kumari Das; Zameer Ahmed; Sambreen Zameer
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 3 (2023): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i3.8627

Abstract

Immunostimulants and adaptogens from plants have acquired important consideration in recent times on account of their potential to reinforce the invulnerable system's response and advance overall prosperity. This study proposed to survey the different range of plant-derived compounds accompanying immunostimulant and adaptogenic characteristics, consider their systems of operation, and argue their potential therapeutic requests. An inclusive essay review was administered to recognize relevant studies and assemble a dossier on plant-located immunostimulants and adaptogens. Results disclosed a myriad of plant compounds, containing polysaccharides, polyphenols, alkaloids, and terpenoids, that exhibit immunostimulant properties by modulating miscellaneous invulnerable pathways. These compounds were erected to embellish the venture of immune containers, in the same way that macrophages, T cells, and everyday murderer cells reconstruct the corpse's armament against contamination and diseases. Furthermore, adaptogens, generally plants like Rhodiola rosea, Panax ginseng, and Withania somnifera, were proven to help the material suit stressors, both material and subjective. These adaptogenic compounds, to a degree saponins and withanolides, exercise their belongings through the hypothalamic-pituitary-adrenal (HPA) point around which something revolves and the regulation of stress birth control method levels. They lighten the damaging impact of incessant stress on the invulnerable system, advancing elasticity and overall fitness
The Challenges and Future of Advanced Therapies Rehan Haider; Asghar Mehdi; Anjum Zehra; Geetha Kumari Das; Zameer Ahmed
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 4 (2024): April 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i4.8628

Abstract

Advanced therapies, including gene therapies, cell-based therapies, and tissue engineering, have emerged as revolutionary approaches in medicine. These therapies hold immense promise for treating previously un treatable diseases by targeting underlying causes at the molecular and cellular levels. However, their translation from laboratory breakthroughs to clinical applications is accompanied by significant challenges that must be addressed to realize their full potential. One major challenge lies in the complexity and variability of patient responses. The personalized nature of advanced therapies demands precise customization of each individual, necessitating the development of robust biomarkers and predictive models. Ensuring the safety of these therapies is paramount. Unforeseen immune reactions, off-target effects, and long-term consequences require stringent preclinical testing and vigilant post-market surveillance. Manufacturing scalability is another hurdle. Unlike traditional pharmaceuticals, advanced therapies often involve intricate processes specific to each patient. Standardizing and automating these processes, while maintaining product quality and consistency, are critical obstacles. Moreover, the high costs associated with research, development, manufacturing, and delivery hinder accessibility and affordability, raising concerns about equitable patient access. The regulatory landscape also requires adaptation to accommodate the unique attributes of advanced therapies. Striking a balance between timely access to patients and comprehensive evaluation of safety and efficacy challenges regulatory agencies globally. Intellectual property concerns, data sharing, and ethical considerations compounded these issues
Continuing Changes in Pharmaceutical Education Rehan Haider; Anjum Zehra; Asghar Mehdi; Geetha Kumari; Zameer Ahmed; Sambreen Zameer
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 4 (2024): April 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i4.8629

Abstract

Landscape The field of drug direction has maintained important progress in the current age, impelled by advances in VCRs, changes in healthcare transmission, and advanced patient needs. This part provides a survey of the continuous changes in drug education, stressing key styles and future counseling. It awards the unification of learning into instruction structures, the meaning of buried professional information, the increasing significance of experienced information, and the need for enduring instruction between a business establishment that sells goods and specialists. Additionally, it investigates the function of drug instruction in directing general substance challenges, boosting type and addition, and advancing change in drug judgments and occurrence. As the healthcare environment resumes to progress, drug command must be used to guarantee that drugstore graduates are outfitted with the knowledge, talents, and abilities needed to meet the demands of the proclamation and provide superb patient care
Antibacterial Activity of Naturally Occurring Compounds from Selected Plants Rehan Haider; Asghar Mehdi; Anjum Zehra; Geetha Kumari Das; Zameer Ahmed
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 4 (2024): April 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i4.8630

Abstract

The abstract presents a short survey of the study fact-finding the uncontaminated endeavor of normally occurring compounds derived from selected plants. This study investigated the potential of these compounds as uncontaminated powers in the field of unrefined brand-located drug discovery. The research complicated the distillation of bioactive compounds from a variety of plant beginnings famous for their curative properties. Therefore, these compounds were assigned to decontaminating assays against a range of bacterial strains by exploiting standard microbiological methods. The results revealed meaningful decontaminating activity of various compounds, signifying their potential as open opportunities for fighting bacterial contamination. Furthermore, this study delves into the systems latent the noticed completely clean belongings, peeling light on the biochemical pathways afflicted by these easily occurring compounds. This mechanistic intuitiveness embodies our understanding of the fashion of operation of compounds, which is critical for the occurrence of mean uncontaminated therapies. Additionally, this study debates the potential requests of these everyday compounds in drug and healthcare enterprises. The uncontaminated endeavor explained by these compounds desires their application for further growth and optimization, concreting the habit for novel healing mediations in the battle against bacterial contamination
Drug Development Research in Women Rehan Haider; Asghar Mehdi; Anjum Zehra; Geetha Kumari Das; Zameer Ahmed; Sambreen Zameer
International Journal of Scientific Multidisciplinary Research Vol. 2 No. 5 (2024): May 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v2i5.8807

Abstract

Drug research in wives is a critical district that has acquired growing consideration in recent ages. Historically, mothers have diminished in clinical tests, chief to a lack of understanding about in what way or manner drugs influence them otherwise distinguished to brothers. This information gap has important associations for drug security and efficiency, as physiological dissimilarities between genders can impact drug absorption, productiveness, and adverse belongings. In answer, skilled has existed a growing importance on containing girls in dispassionate trials and attending grammar principles that apply to nouns with sexual or animated connotations reasonings to guarantee that drugs are safe and persuasive for two together people interested in something. This paper provides an overview of the significance of containing mothers in drug-producing research. It discusses the classical circumstances of feminine bias in dispassionate trials and the supervisory changes that have been executed to address this issue. The paper again highlights the corporeal and hormonal distinctnesses middle from two points people that can influence drug responses. Furthermore, the paper tries to the challenges and space in drafting and maintaining women in dispassionate tests, containing righteous considerations and educational determinants
Omega-3 Fatty Acids, Tryptophan, B Vitamins, SAME, and Hypericum in the Adjunctive Treatment of Depression Rehan Haider; Asghar Mehdi
International Journal of Integrative Sciences Vol. 3 No. 1 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijis.v3i1.6568

Abstract

The adjunctive treatment of melancholy has garnered good attention as researchers and healthcare providers seek opportunities and complementary tactics to improve outcomes for people suffering from depressive disorders. This abstract explores the therapeutic benefits of mixing omega-3 fatty acids, tryptophan, B vitamins, S-adenosyl methionine (same), and Hypericum (St. John's Wort) as adjunctive treatments for melancholy. Omega-3 fatty acids, found in fatty fish and certain plant sources, have shown promise in alleviating depressive signs and symptoms. Their anti-inflammatory and neuroprotective homes may also contribute to advanced temper and ordinary well-being. Tryptophan, an important amino acid, performs a vital role in serotonin synthesis, a neurotransmitter associated with temper regulation. Supplementing tryptophan may additionally enhance serotonin production and alleviate the signs and symptoms of melancholy. B vitamins, specifically B6, B9 (folate), and B12, are vital for correct mind function and neurotransmitter synthesis. Deficiencies in these nutrients are connected to mood disturbances. Adjunctive B diet supplementation can doubtlessly assist traditional despair treatments by addressing dietary deficiencies. S-adenosyl methionine (same) is an occurring compound concerned with diverse biochemical procedures, which include the synthesis of neurotransmitters. Equal supplementation has confirmed efficacy in enhancing temper and may be taken into consideration as an adjunctive treatment choice for melancholy