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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Pasak Bumi Kalimantan Jurnal Sains dan Kesehatan
Achmad, Andika Adi Saputra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Sains dan Kesehatan

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Stadium dan Tipe Histopatologi Kanker Serviks pada Pasien Kanker Serviks dengan Kemoradiasi di RSUD Abdoel Wahab Sjahranie Samarinda Periode 2021-2022: Stage and Histopathology Type of Cervical Cancer in Cervical Cancer Patients with Chemoradiation at Abdoel Wahab Sjahranie Hospital Samarinda 2021-2022 Periods Maharani, Anggita; Hasanah, Nurul; Achmad, Andika Adi Saputra; Ngo, Novia Fransiska; Sawitri, Endang
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2447

Abstract

Cervical cancer is a malignancy resulting from the uncontrolled development of cells in the cervix, making it the second most prevalent form of cancer in Indonesia. Currently, cancer treatments comprise surgical intervention, chemotherapy, and radiotherapy, or in conjunction, depending on the stage of the disease. This study aims to identify the stage and histopathological type of cervical cancer in cervical cancer patients with chemoradiation as well as urea levels and creatinine levels before patients underwent chemoradiation at Abdoel Wahab Sjahranie Regional Public Hospital Samarinda between 2021 and 2022. A cross-sectional study design was employed, encompassing 116 medical record data. Overall, the majority of cervical cancer patients who receive chemoradiation were in the histophatological type of squamous cell carcinoma (75%), predominantly at Stage II (64,3%), have anemia in their hemoglobin  levels (57,8%), and normal levels of urea and creatinine were (75%) and (91,4%) respectively. Keywords:          cervical cancer, chemoradiation, histopathological type, stage, creatinine   Abstrak Kanker serviks merupakan keganasan yang disebabkan oleh pertumbuhan sel yang tidak terkendali pada leher rahim, menduduki urutan kedua kanker terbanyak di Indonesia. Pengobatan kanker meliputi terapi pembedahan, kemoterapi, dan radioterapi, atau kombinasi sesuai dengan stadium. Tujuan penelitian ini adalah untuk mengetahui stadium dan tipe histopatologi kanker serviks pada pasien kanker serviks dengan kemoradiasi serta kadar ureum dan kadar kreatinin sebelum pasien menjalani kemoradiasi di RSUD Abdoel Wahab Sjahranie Samarinda periode 2021-2022. Desain penelitian cross-sectional menggunakan 116 data rekam medis. Hasil penelitian menunjukkan bahwa pasien kanker serviks terbanyak pada kelompok tipe histopatologi karsinoma sel skuamosa (75%), stadium pasien kanker serviks terbanyak adalah stadium II (64,3%), dan kadar hemoglobin terbanyak pada kelompok anemia (57,8%), serta kadar ureum dan kreatinin masing-masing pada kelompok normal sebesar (75%) dan (91,4%). Kata Kunci:         kanker serviks, kemoradiasi, tipe histopatologi, stadium, kreatinin  
Hubungan Kadar Serum Cancer Antigen-125 dengan Stadium Kanker Ovarium Tipe Epitel: Correlation between Serum Levels of Cancer Antigen-125 and Stages of Epithelial Type Ovarian Cancer Lestari, Della Ayu; Rachmi, Eva; Achmad, Andika Adi Saputra
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.2237

Abstract

Ovarian cancer has the worst prognosis of all gynecologic malignancies in women. The five-year survival rate for ovarian cancer is only 30%–50% in Indonesia. The most common histological type in ovarian cancer incidence is epithelial ovarian cancer (90%). Ovarian cancer is still one of the deadliest gynecological cancers because there is no effective technique for predicting the stage of ovarian cancer. The accuracy of CA-125 as a tumor marker in determining the stage of ovarian cancer is still being argued. This study analyzes the relationship between serum CA-125 levels and the stage of epithelial type ovarian cancer at Abdoel Wahab Sjahranie Hospital Samarinda, which was conducted from August to December 2023. This research is an analytical observational with a cross-sectional approach. The sampling technique was purposive sampling, with secondary data in the form of medical records, sample totaled 30 patient. Bivariate analysis was carried out using the one way ANOVA test. The relationship between serum CA-125 levels and the stage of epithelial ovarian cancer was not significant overall (p = 0.052). Further tests revealed a significant difference between serum CA-125 levels and the stage of epithelial type ovarian cancer, especially at stage I and stage III (p = 0.027). Keywords:          Serum CA-125 Levels, Epithelial Type of Ovarian Cancer, Stage   Abstrak Kanker ovarium memiliki prognosis terburuk dari seluruh keganasan ginekologi pada wanita. Kesintasan lima tahun kanker ovarium hanya 30%–50% di Indonesia. Tipe histologis paling umum pada insidensi kanker ovarium adalah kanker ovarium tipe epitel (90%). Kanker ovarium masih menjadi salah satu kanker ginekologi paling mematikan karena belum ada teknik yang efektif untuk memprediksi stadium kanker ovarium. Akurasi CA-125 sebagai salah satu penanda tumor dalam menentukan stadium kanker ovarium masih menjadi perdebatan. Penelitian ini menganalisis hubungan antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel di RSUD Abdoel Wahab Sjahranie Samarinda, yang dilakukan pada bulan Agustus hingga Desember 2023. Penelitian ini berupa observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel melalui purposive sampling, dengan data sekunder berupa rekam medis. Sampel berjumlah 30 pasien. Analisis bivariat dilakukan dengan uji one way ANOVA. Hubungan antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel secara keseluruhan adalah tidak bermakna (p = 0,052). Uji lanjut didapatkan perbedaan yang bermakna antara kadar serum CA-125 dengan stadium kanker ovarium tipe epitel, khususnya pada stadium I dan stadium III (p = 0,027). Kata Kunci:         Kadar Serum CA-125, Kanker Ovarium Tipe Epitel, Stadium
Co-Authors Anggita Maharani Della Ayu Lestari Endang Sawitri Eva Rachmi Evi Fitriany Novia Fransiska Ngo Nurul Hasanah Pradita, Shelya Duan Rahma, Rosyida Muthia Siti Fatimah Yudia, Riries Choiru Pramulia Yuniati Yuniati