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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Prosiding Seminar Nasional COSMIC Kedokteran
Idawati, Ira
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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ACE I/D and A2350G Polymorphisms are Correlated with Body Mass Index, but Not with Body Weight and Essential Hypertension: Study in Javanese Postmenopausal Women Utami, Sri Lestari; Simamora, Dorta; Idawati, Ira; Widjaja, Jimmy Hadi
Molecular and Cellular Biomedical Sciences Vol 8, No 2 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i2.426

Abstract

Background: Genetics was one of the risk factors for essential hypertension (EH). Research on ACE I/D and A2350G polymorphisms associated with risk factors for hypertension in Indonesia has never been done. Therefore, this study was conducted to analyze the relationship between the genotype and alleles of this gene with EH, body weight, and body mass index (BMI) in Javanese postmenopausal women.Materials and methods: This cross-sectional study involved 69 postmenopausal Javanese women according to several criteria related with hypertension risk factors. The data were obtained from the measurement and questionnaire results, along with Towards Health Card Records. The polymerase chain reaction (PCR) genotyping method used was the restriction fragment length polymorphism and allele-specific.Results: The prevalence of hypertension, prehypertension, and normotension in Javanese postmenopausal women were 0.246, 0.13, and 0.623, respectively. The frequency of BMI classification as underweight, normal, overweight, or obese were 0.029, 0.42, 0.261, and 0.29, respectively. The ACE I/D and A2350G polymorphism variant genotypes and frequencies found were II (0.464), ID (0.522), DD (0.014), and AA (1). Meanwhile, the alleles and their frequencies at ACE I/D gene polymorphism were I (0.725) and D (0.275). The II and ID genotype was mostly found in normotension subjects. The DD genotype was only available in hypertension subjects. There was no association between genotypes and alleles of ACE I/D, hypertension, body weight, and BMI classification (p>0.05). There was an association between these genotypes, alleles, and BMI (p<0.05).Conclusion: ACE I/D polymorphism is susceptible for BMI in Javanese postmenopausal women.Keywords: Javanese postmenopausal, essential hypertension, ACE I/D, ACE A2350G
STUDI LITERATUR: HUBUNGAN ANTARA PEROKOK PASIF DENGAN KEJADIAN KANKER PAYUDARA PADA WANITA Hilungara, Umbu Reku Djawa Tana; Sunaryati, Titiek; Idawati, Ira
Prosiding Seminar Nasional COSMIC Kedokteran Vol 3 (2025): Edisi 2025
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Kanker payudara merupakan keganasan paling umum terjadi di seluruh dunia dan salah satu penyebab utama kematian pada Wanita setelah kanker pernafasan. Salah satu faktor yang menyebakan kanker payudara ialah asap rokok. Penelitian ini memiliki tujuan umuntuk mengetahui adanya hubungan antara perokok pasif dengan kejadian kanker payudara pada wanita. Penelitian ini menggunakan metode literature review yang bersifat deskriptif dengan pengumpulan data/informasi, analisis dan pemecahan masalah. Beberapa penelitian menunjukkan bahwa kultur sel yang diekspose dengan asap rokok akan meningkatkan level NF-kB aktif dan memacu ekspresi protein cyclin D, protein yang sangat diperlukan untuk awal pembelahan sel. Dengan sifat yang demikian ini maka senyawa PAH juga akan dapat memicu perkembangan tumor lebih cepat lagi. Kesimpulannya ialah adanya hubungan antara perokok pasif dengan kejadian kanker payudara pada wanita.
Co-Authors Dorta Simamora Hilungara, Umbu Reku Djawa Tana Titiek Sunaryati, Titiek Utami, Sri Lestari Widjaja, Jimmy Hadi