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All Journal Indonesia Natural Research Pharmaceutical Journal (INRPJ) Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri
Risty Setyati Ashari
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Engineering Immunology & microbiology Medicine & Pharmacology Social Sciences

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Manfaat Daun Belimbing Wuluh Sebagai Terapi dalam Membantu Pengobatan Penyakit Kardiovaskular (Hipertensi) Yelfi Anwar; Egy Octaviani; Grace Tandiseru; Laila Safa Asrianti; Rafael Rafael; Risty Setyati Ashari; Raden Roro Putri Nur Ramadhania
Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri Vol. 3 No. 3 (2024): Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri
Publisher : Universitas Maritim AMNI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58192/sejahtera.v3i3.2355

Abstract

Hypertension is one of the most common and serious health problems in society, which can cause complictions such as heart disease, stroke and kidney failure. This study examines the use of starfruit leaves (Averrhoa bilimbi) as an adjuvant therapy in the treatment of hypertension. The aim of this community service program is to increase public knowledge and understanding of the benefits of starfruit leaves in the treatment of hypertension, as well as provide education on how to process starfruit leaves into a safe and effective herbal concoction. The results of the pre-test and post-test obtained showed that the pre-test percentage was correct at 88.7% and the percentage value incorrect was 12.3%, while the post-test percentage correct was 98.7% and the percentage value incorrect was 2.3%. The conclusion of this program is that education regarding the use of starfruit leaves can increase public understanding about alternative treatments for hypertension based on local plants.
ISOLATION OF ARBUTIN FROM SUKUN (ARTOCARPUS ALTILIS [PARK.] FOSBERG.) LEAF AND STEM EXTRACTS AS A TYROSINASE INHIBITOR Zuraida Sagala; Risty Setyati Ashari
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.9220

Abstract

This study aims to isolate arbutin compounds from 70% ethanol extract of breadfruit (Artocarpus altilis) leaves and stems, determine the levels of arbutin in the extract, and evaluate the inhibitory activity of tyrosinase enzyme. Isolation was carried out through extraction and fractionation methods using n-hexane, ethyl acetate, and butanol solvents. Identification of arbutin was carried out by High Performance Liquid Chromatography (HPLC) based on the suitability of retention time to the standard. The results showed that the level of arbutin in 70% ethanol extract of breadfruit leaves was 14.84 mg/L and breadfruit stems was 14.81 mg/L. Tyrosinase activity test showed that ethyl acetate fraction of breadfruit leaves had the highest effectiveness as tyrosinase inhibitor with IC₅₀ value of 355.24 ppm, compared to crude extract and other fractions. Although the activity has not matched the positive control kojic acid (IC₅₀ = 39.28 ppm), these results indicate the potential of breadfruit leaf and stem extracts as a source of natural active ingredients for skin lightening
Co-Authors Anwar, Yelfi Egy Octaviani Grace Tandiseru Laila Safa Asrianti Raden Roro Putri Nur Ramadhania Rafael Rafael Zuraida Sagala