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All Journal E-journal Widya Eksakta Majalah Obat Tradisional BIOEDUKASI Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Current Research on Biosciences and Biotechnology Bioscientist : Jurnal Ilmiah Biologi Jurnal Kesehatan KREATIF: Jurnal Pengabdian Masyarakat Nusantara Pharmaceutical Sciences and Research (PSR) Berdikari : Jurnal Pengabdian kepada Masyarakat Pharmacy Action Journal Media Bina Ilmiah Sejahtera: Jurnal Inspirasi Mengabdi Untuk Negeri Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Nuras : Jurnal Pengabdian Kepada Masyarakat Jurnal Kabar Masyarakat Kreativitas Pada Pengabdian Masyarakat (Krepa) Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Mitra Pengabdian Farmasi

Anwar, Yelfi

17 Agustus 1945 Jakarta University

Author-ID : 900892

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANALISIS PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU KASUS BARU RAWAT JALAN DI RUMAH SAKIT ATMA JAYA Anwar, Yelfi; Ayuni, Fitri
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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ABSTRACT Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. The prevalence of pulmonary tuberculosis incident was included in the top 10 highest disease at Atma Jaya Hospital. Therefore, the study of the analysis of the use of anti-tuberculosis drugs in patients with new cases of lung rational at Atma Jaya Hospital indispensable. The purpose of this study was to determine the profile and analyze the rationality of the use of anti-tuberculosis drugs used in outpatients suffering from pulmonary tuberculosis new cases over the period July 2013 - June 2014.

IBM â€“ PEMBERDAYAAN MASYARAKAT DALAM PRODUKSI MINYAK SEREH WANGI DI KELURAHAN PONDOK PETIR KECAMATAN BOJONGSARI DEPOK JAWA BARAT Anwar, Yelfi; Siringoringo, Victor Sahat; Firman, -; Sudirman, -; Rusdi, Rafflis
E-journal Widya Eksakta Vol 1 No 2 (2018)
Publisher : E-journal Widya Eksakta

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Minyak Sereh (Cymbopogon Nardus) adalah salah satu minyak esensial yang paling banyak diproduksi di Indonesia. Saat ini, minyak sereh banyak digunakan sebagai campuran makanan, minuman, energi, kosmetika dan obat-obatan. Industri pengolahan minyak sereh wangi masih menggunakan proses produksi tradisional. Kualitas dan kuantitas minyak sereh wangi juga perlu ditingkatkan mengingat potensi besar untuk ekspor. Tujuan dari penelitian ini adalah untuk meningkatkan pengetahuan dan keterampilan masyarakat, memberikan bimbingan dan bantuan dari pihak yang berkompeten, meningkatkan kualitas dan kuantitas produksi minyak sereh wangi, mengembangkan usaha pemanfaatan lahan dan komersialisasi. Metode penelitian dengan melaksanakan Focus Group Discussion (FGD) dan melaksanakan uji coba produksi dengan menggunakan mesin destilasi dengan kapasitas 6 Kg daun sereh wangi. Proses destilasi yang dilakukan dengan menggunakan metode destilasi air - uap. Lama proses destilasi 3-4 Jam. Dengan karakteristik minyak yang dihasilkan warna kuning pucat, total geraniol 82,36%, Sitronellal 17,55%. Permintaan pasar akan minyak sereh wangi cukup tinggi. Baik yang diperoleh dari pemasaran secara online ataupun melalui media sosial lainnya. Saat ini mesin produksi yang tersedia juga disewakan kepada peneliti. Hasil dari kegiatan pengabdian masyarakat ini adalah peningkatan pemahaman masyarakat dalam produksi minyak sereh wangi dan menjadi sumber pemasukan bagi masyarakat kelurahan Pondok Petir.

Prediction of Geraniol Bond Mode in Aspergillus niger Linalool Dehydratase – Isomerase Yelfi Anwar; Andrianopsyah Mas Jaya Putra; Elvina Dhiaul Iftitah; Partomuan Simanjuntak; Shirly Kumala
Majalah Obat Tradisional Vol 24, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Geraniol is a very valuable aroma chemical and has commonly been used in fragrances and aroma compound. Geraniol biotransformation by Aspergillus niger has been studied. The main bioconversion products obtained from geraniol and liquid culture of A. niger are linalool and alpha-terpineol. Linalool plays a major role in anti-inflammatory, antibacterial and antioxidant activities. This study aims to know the interaction of geraniol in Aspergillus niger enzyme with docking molecular. Comparative modeling of Aspergillus niger enzyme was conducted by means of one of the crystal structure of Linalool Dehydratase – Idomerase (LDI) as a template. The best model of this comparative modeling was then used in docking molecular to investigate geraniol binding mode inactive site enzyme of Aspergillus niger. Inactive site enzyme of Aspergillus niger, geraniol is located with hydrophobic and hydrogen bonds: Amino acid – the amino acids are Asn 105, Arg 96, Lys 112 inactive site - OH with hydrogen bond, Arg 97 inactive site – CH3 with hydrophobic bond and Leu54 inactive site – CH3 with the hydrophobic bond. The distances among pharmacophore respectively are 3,603 A, 6,768 A, and 7,345A. It has higher score (ΔGbind: -3.4 kcal/mol) compared to linalool (ΔGbind: -3.6 kcal/mol). Virtual tethering of linalool with LDI Aspergillus niger enzyme in amino acid Leu120 and Glu118 had been done. The pharmacophore is - OH and methyl C8 group. The distances among pharmacophore respectively are 5,835 Å, 2,52 Å, and 5,32 Å. Virtual tethering of LDI Aspergillus niger enzyme with geraniol has a higher score (ΔGbind: -3.4 kcal/mol) compared to linalool (ΔGbind: -3.6 kcal/mol). It shows that interaction between linalool and LDI Aspergillus niger enzyme is easier to occur than the interaction between geraniol and LDI Aspergillus niger enzyme, geraniol reaction to linalool that occurs is rearrangement reaction.

Isolation of citronellal from Cymbopogon nardus (L) Rendle and its activity test as a burn healing in mice Yelfi Anwar; Novia Aditia Ningtiyas; Partomuan Simanjuntak
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/NODZ4501

Citronellal is one of the main compounds of essential oils of Cymbopogon nardus (L) Rendle, which is the most important chemical compound in the cosmetics and pharmacy industry. This study aimed to isolate the citronellal from the essential oil of Cymbopogon nardus (L) Rendle and activity on burns in male white mice (Mus musculus (L). The isolation method used column chromatography and n-hexane-ethyl acetate as eluent (20 : 1). The isolate obtained was used to burn activity on the back of male white mice (Mus musculus (L)). The ointment formula 0.25%, 0.5% and 1% were prepared using vaseline flavum. Based on the test using thin layer chromatography with the addition of cerium sulphate as a spotting appearance, was given one spot in the 4th isolate. Based on characterization data by UV-Vis spectrum, FTIR spectrum and GC-MS chromatogram showed that F4 isolate was citronellal. Based on the results of the burn activity on all concentrations, formula 1% showed the best burn healing activity. Citronellal can be isolated from the essential oil of Cymbopogon nardus (L) Rendle and has healing activities for burns in male white mice.

Profile Of Antiretroviral Side Effects On Hiv In Rspi Prof. Dr. Sulianti Saroso Jakarta Yelfi Anwar; Sucahyo Adi Nugroho; Sri Dwi Wulandari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Symptoms of Acquired Immuno Deficiency Syindrome (AIDS) is a militia or disease caused by me infection of Human Immunodeficiency immune deficiency due to Antiretroviral. Due to Virus (HIV). The therapy used is a drug that the use of Antretroviral is the appearance of unwanted reactions or side effects will appear. The objectives of the study were to analyze the side effects of antiretroviral therapy in HIV / AIDS patients in RSPI Sulianti Saroso, North Jakarta, January-June 2016 period. The sample was 95 patients. The research was done by retrospective method, data analysis desknptif data presented in tabular form and presented with pie chart. The result of the research is the combination of TDF + 3TC + Efavirenz Tenofovir-Lamivudin-Efavirenz) as much as 73,68% (0 person). There were 94.73% (90 people had mild adverse reactions and 5.27% (5 people) severe side effects.

Isolasi dan Identifikasi Snyawa Geraniol dari Minyak Atsiri Tanaman Sereh Wangi Cymbopogon nardus (L.) Rendle Yelfi Anwar; Shirly Kumala; Elvina Dhiaul Iftitah; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Background: Indonesia is a major producer of several essential oils such as citronella oil, clove oil, cananga oil, vetiver oil, sandalwood oil, and patchouli oil. The Cymbopogon (Poaceae) genus has the most important components of essential oils, namely citral, geraniol, citronellol, citronellal. Geraniol is one of the most important chemical compounds in the aroma and fragrance industry and shows the nature of insecticides and natural insect repellents which show low toxicity and is suggested to represent a new class of chemoprevention agents for cancer, antimicrobial, anti-oxidant, anti-inflammatory and some vascular effects Transdermal drugs also attract the attention of researchers and scientists in the field of formulation. Objective: This study aimed to obtain geraniol compounds obtained from Cymbopogon nardus (L.) Rendle and identification. Methodology: The citronella, essential oil was obtained from the Cymbopogon nardus (L) Rendle plant using a water-steam distillation method, then fractionation was carried out and continued by purification isolation by column chromatography. Results: Based on the interpretation of IR data, Core magnetic resonance (proton and carbon RMI) and mass spectra for isolate 5 were determined as geraniol compounds. Conclusion: Geraniol can be obtained from Cymbopogon nardus (L) Rendle plants by water-steam distillation, fractionation and isolation methods.

ANALISIS PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU KASUS BARU RAWAT JALAN DI RUMAH SAKIT ATMA JAYA Yelfi Anwar; Fitri Ayuni
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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EVALUASI PENGGUNAAN ANTIBIOTIKA PADA PENGOBATAN PENDERITA PNEUMONIA ANAK DI INSTALASI RAWAT INAP RSUD PROF. DR. W. Z. JOHANNES KUPANG PERIODE JANUARI – JUNI 2015 Yelfi Anwar; Maria Elisabeth Bota Benny Horang
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 02 Desember 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Penggunaan antibiotika yang tepat ialah penggunaan antibiotika yang efektif dengan peningkatan efek terapeutik, sehingga meminimalkan terjadinya resistensi dan meminimalkan biaya obat. Penggunaan antibiotika yang rasional harus memenuhi beberapa kriteria yaitu, tepat pasien, tepat indikasi, tepat obat, tepat dosis, dan tepat lama pemberian. Penelitian ini bertujuan untuk mengevaluasi kerasionalan penggunaan antibiotika pada pengobatan pneumonia anak di Instalasi Rawat Inap RSUD Prof. Dr. W.Z. Johannes, Kupang, periode Januari–Juni 2015. Penelitian ini berupa penelitian deskriptif dengan pengumpulan data secara retrospektif yang didasarkan pada catatan medis. Penelitian dilakukan terhadap 41 catatan medis penderita pneumonia anak yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan jenis antibiotika yang paling banyak digunakan pada pneumonia anak ialah kombinasi antibiotika ampisilin-gentamisin sebesar 46,34% dan ampisilin-kloramfenikol sebesar 14,63%. Evaluasi penggunaan antibiotika berdasarkan kriteria tepat pasien (100%), tepat indikasi (100%), tepat obat (21,95%), tepat dosis (51,22%), dan tepat lama pemberian (53,66%). Terdapat hubungan yang signifikan (p=0,021) antara berat badan dengan kerasionalan penggunaan antibiotika. Appropriate use of the antibiotic is effective use to increase therapeutic clinical effect, minimized the occurrence of resistance, and effective terms of cost. Rational use of antibiotics have to comply with several criteria like the appropriate patient, appropriate indication, appropriate drug, appropriate dose, and appropriate duration. This study was aimed to evaluate the rational utilizing of antibiotics in the treatment of pediatric pneumonia in Hospitalized Installation of RSUD Prof. Dr. W.Z. Johannes Kupang in period January–June 2015. This research is a descriptive study with retrospective data aggregation based on medical records. Research conducted on 41 pediatric patiens medical record with pneumonia who fulfill the inclusion criteria. The result showed that antibiotics are the most used antibiotics combination is ampicillin-gentamicin were 46,34% and ampicillin-chloramphenicol were 14.63%. Evaluation of rational use of antibiotics to the appropriate patient (100%), appropriate indication (100%), appropriate drug (21.95%), appropriate dose (51.22%) and appropriate duration (53.66%). There is a significant (p=0.021) relationship which between weight rasionality use with antibiotics.

Karakteristik Sosiodemografi, Klinis, Dan Pola Terapi Antiretroviral Pasien HIV/AIDS di RSPI Prof. Dr. Sulianti Saroso Periode Januari - Juni 2016 Yelfi Anwar; Sucahyo Adi Nugroho; Niken Diaz Tantri
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 15 No. 01 Juli 2018
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

HIV/AIDS merupakan suatu penyakit yang disebabkan oleh infeksi human immunodeficiency virus. Penyakit ini mengganggu sistem kekebalan tubuh dengan menekan dan menurunkan jumlah sel CD4 sehingga meningkatkan risiko infeksi oportunistik yang dapat dicegah dengan adanya terapi antiretroviral. Penelitian ini bertujuan untuk mengetahui karakteristik sosiodemografi, klinis, dan pola terapi antiretroviral pada pasien HIV/AIDS di RSPI Prof. dr. Sulianti Saroso periode Januari-Juni 2016. Desain penelitian ini adalah deskriptif dengan penelusuran data bersifat retrospektif. Sampel dalam penelitian ini adalah 124 pasien HIV/AIDS yang mendapatkan terapi antiretroviral di klinik Pokja HIV/AIDS dalam kurun waktu Januari hingga Juni 2016 data diambil dari rekam medis. Hasil penelitian menunjukkan pasien HIV/AIDS didominasi oleh laki-laki (74,19%) usia 30-39 tahun (40,32%) dengan jumlah CD4 terbanyak dibawah 200 sel/µl (59,29%) dengan stadium I (44,35%) disertai infeksi kandidiasis (17,74%), dimana pola terapi lini I yang digunakan adalah Tenofovir + Lamivudine + Evafirens (65,23%) dengan kepatuhan pasien 75%. Diharapkan penelitian ini dapat bermanfaat untuk perumusan program pencegahan dan tatalaksana HIV/AIDS di masa mendatang.

UJI АKTIVITАS АNTIINFLАMАSI MINYАK GOSOK MINYАK АTSIRI SERАI WАNGI (Cympobogon nаrdus) TERHАDАP TIKUS PUTIH JАNTАN (Rаttus norvegicus) Yelfi Anwar
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 3, No 2 (2018)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Inflаmаsi аdаlаh respon terhаdаp cederа jаringаn dаn infeksi. Ketikа proses inflаmаsi berlаngsung, terjаdi reаksi vаskulаr dimаnа cаirаn, elemen-elemen dаrаh, sel dаrаh putih dаn mediаtor kimiа berkumpul pаdа tempаt cederа jаringаn аtаu infeksi. Minyаk аtsiri serаi wаngi memiliki kаndungаn sitronelаl, gerаniol, sitronelol, gerаnil аsetаt dаn lаinnyа. Penelitiаn ini bertujuаn untuk mengetаhui аktivitаs аntiinflаmаsi minyаk gosok minyаk аtsiri serаi wаngi pаdа tikus putih jаntаn yаng diinduksi putih telur 5% dаn untuk mendаpаtkаn stаbilitаs fisik yаng bаik dаri minyаk gosok minyаk аtsiri. Penelitiаn dilаkukаn menggunаkаn tikus putih gаlur Spаrаgue dаwley dengаn 25 ekor dibаgi 5 kelompok, yаng terdiri dаri Kontrol Negаtif (Oleum Аrаchidis), Kontrol Positif (Minyаk Gosok GPU), dаn Kelompok Perlаkuаn dengаn konsentrаsi 2%, 3% dаn 5%. Hаsil penelitiаn menunjukаn konsentrаsi 5% memberikаn аktivitаs аntiinflаmаsi yаng pаling bаik dibаndingkаn konsentrаsi lаinnyа dilihаt dаri nilаi Аuc totаl dаn persen penghаmbаtаn inflаmаsi. Konsentrаsi 5% jugа merupаkаn formulа yаng memiliki stаbilitаs fisik yаng bаik dibаndingkаn dengаn konsentrаsi lаinnyа.Kata kunci: Аntiinflаmаsi, Cymbopogon nаrdus (L) Rendle, Minyаk аtsiri, Minyаk Gosok

Co-Authors Ade Via Jualiana Agnes Lenoera Akifah, Hana Tri Alicia Alicia Alifvia Nurcahyani Ance Tenouye Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Andrianopsyah Mas Jaya Putra Angel Maria Simatupang Angela Imelda Cahaya Atisi, Atisi Ayunda Fajarni Rahmi Ayuni, Fitri Berliano Karvenio Dasmyta, Eny Desty Andiani Dewi Puspitasari Dhea Setyalova Wibawanto Diajeng Para Mitha Dias Septiana Sari Efa Bonita Efa Bonita Egy Octaviani Eka Kristina Eka Syafitri Puspita S Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Epifani Januar P Etika Dewi Maharani Fathur Rahman Fatimah Tibbiya Feby Bethariya O Fikri, Muhammad Sayid Ali Firman, - Fitri Ayuni Gabriel Janiva Gabriela, Jean Grace Tandiseru Gracia Lai Gavia Wau Hallimah Vira Maulida Ikramullah, Nazwa Indah Mareta Dwi Editia Istiqomah, Fajriatul Jodi Apriadi Kartika Kartika Keysha Rayi Tifani Laila Safa Asrianti Laras Puspita Dewi Lesli Tiana Lily Suciati Lulu Najmah Madelyne Yuliana Insanie Maeesa Putri Lathiifah Maria Elisabeth Bota Benny Horang Marisa Tamara Sari Marisa Tamara Sari Maryan, Roni Maryana, Roni Michael Michael Muhammad Dimas An-Naf Muhammad Nazzal Muhyiddin Al Firmansyah Muryanto Muryanto, Muryanto Naplatul Mahmudah Nia Khorotun Fadillah Niken Diaz Tantri Ni’am, Laelatun Nonik, Nonik Novia Aditia Ningtiyas Nurul Diniah Oktavia Anggrainy Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Permatasari, Nurfebby Piter Piter Raden Roro Putri Nur Ramadhania Rafael Rafael Rahmadani, Nur Fitri Ratih Hardianti Regina Regina Rina Pebriani Riska Rahmadani Risty Setyati Ashari Ruminah Rusdi, Rafflis Sari, Eka Syafitri Puspita Sari, Sintya Puspita Seftian Putra Dwijaya Marpaung Sembiring, Rinawati Setya Astuti Shirly Kumala Shirly Kumala Silvy Widya Rahmi Siringoringo, Victor S Sri Dwi Wulandari Sucahyo Adi Nugroho Sucahyo Adi Nugroho Sudirman, - Surahman, Dziki Dzikrivan Syari Fatul Hayanis Syifa Alifia Indriani Victor Sahat Siringoringo Vinsensia Asahi Sulan Langit Wd Windi Pratiwi Wibawanto, Dhea Setyalova Windy Annisa Arbah Yofie Aldo Aditya Zahara Nurhazizah Zuli Astuti Salsabilla

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