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Penggunaan Ganja Medis Dalam Pengobatan Rasional Dan Pengaturannya di Indonesia Nur Arfiani; Indah Woro Utami
Jurnal Hukum dan Etika Kesehatan VOLUME 2 NOMOR 1
Publisher : Magister Ilmu Hukum - Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jhek.v2i1.45

Abstract

Medical marijuana (Cannabis sativa) has been used since ancient time. Its use is written in medical books from china, india and even the Mesopotamian era. In these records, the use of marijuana (Cannabis sativa) is not only as a medicine, but also as a food ingredient and a ritual tool. A popular issue in Indonesia today is about legalization of medical marijuana. Marijuana is a class I narcotic which is written in the law. Cannabis has a very high potential to cause addicted and not used for therapy. However, several institutions have discussed that marijuana can be legalized in Indonesia. Cannabis can provide health benefits and has economic potential. Marijuana countains cannabinoids that are considered to have medical benefits. Several countries have developed marijuana into legal medicinal preparations. Economically, medical marijuana has great potential as an export commodity. The approach in this study uses a qualitative method by using data from books, regulations, expert opinions, as well as examining various scientific journal using Garuda, PubMed, Sciencedirect, and Wiley. The result of data analysis is in the form of systematic information. This article can be a reference for development and legalization of medical marijuana in Indonesia.
Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp Asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
Jurnal Rumpun Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v5i3.5522

Abstract

Fungal infections are a common health problem in tropical regions, including Indonesia, since humid conditions support microbial growth. Candida tropicalis is a pathogenic species frequently identified as the cause of both superficial and systemic candidiasis. The rising resistance to synthetic antifungal agents such as fluconazole and ketoconazole highlights the need for safer and more effective alternative therapies. Propolis, a resinous substance produced by Trigona sp. bees from various plant sources, contains flavonoids, phenolics, and terpenoids with important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, tannins, and terpenoids in the extract. Antifungal activity testing showed that concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone of 27.93 mm observed at 100% concentration. Statistical analysis using ANOVA confirmed significant differences among treatments. Thus, ethanol extract of Trigona sp. propolis from Balikpapan demonstrates strong potential as a natural antifungal agent. These findings support the use of propolis as a natural-based therapeutic alternative for fungal infections and contribute to the development of herbal pharmaceutical products.
Analisis Aktivitas Antibakteri Ekstrak Etil Asetat Tanaman Sirih Cina (Peperomia pellucida L.) pada Bakteri Shigella Dysenterie A. Nurul Fitriandini Ekaputri; Indah Woro Utami; Eka Kumala Retno
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3356

Abstract

Dysentery is a gastrointestinal infection characterized by bloody or mucoid diarrhea, abdominal pain, and tenesmus. One of its main causative agents is Shigella dysenteriae , a Gram-negative bacterium capable of causing epidemics and showing resistance to various antibiotics. Therefore, alternative treatments are needed, one of which is the use of traditional medicinal plants such as Peperomia pellucida L. (“sirih cina”). This study aimed to determine the ability of the ethyl acetate extract of Peperomia pellucida L to inhibit the growth of Shigella dysenteriae , and to identify the most effective concentration in exhibiting antibacterial activity. The research was conducted experimentally in the laboratory, involving simplisia preparation, maceration extraction with ethyl acetate, phytochemical screening, and antibacterial testing using the agar well diffusion method. Three extract concentrations were tested (20%, 25%, and 30%), with ciprofloxacin (5 µg) as the positive control and 5% DMSO as the negative control. Phytochemical screening revealed the presence of flavonoids, tannins, and terpenoids, while alkaloids, steroids, and saponins were not detected. Antibacterial assays showed that all extract concentrations inhibited the growth of S. dysenteriae with inhibition zones >20 mm (classified as very strong). The highest activity was observed at 30% concentration with an average inhibition zone of ±22.6 mm, approaching the effectiveness of ciprofloxacin. This study demonstrates that the ethyl acetate extract of P. pellucida possesses strong antibacterial activity and has potential as an alternative or combination therapy to reduce antibiotic resistance.
Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3377

Abstract

Fungal infections are common health problems in tropical regions, including Indonesia, because humid environmental conditions support the growth of these microorganisms. Candida tropicalis is the pathogenic fungal species most frequently found, both as the cause of superficial and systemic candidiasis. The increasing resistance to synthetic antifungal drugs, such as fluconazole and ketoconazole, creates the need for alternative therapies that are safer and more effective. Propolis, a resinous substance produced by Trigona bees from various plant sources, is known to contain flavonoids, phenolics, and terpenoids that have important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening showed that the propolis extract contained alkaloids, flavonoids, phenolics, tannins, and terpenoids. The antifungal activity test demonstrated that extract concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone observed at 100% concentration (27.93 mm). Statistical analysis using ANOVA confirmed significant differences among treatments. Therefore, it can be concluded that propolis extract from Trigona bees in Balikpapan has strong potential as a natural antifungal agent. These findings support the utilization of propolis as an alternative natural-based therapy for fungal infections and as a contribution to the development of natural pharmaceutical products.