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All Journal Jurnal Rumpun Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Muthia Adlina
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Dentistry Health Professions Nursing Public Health Veterinary

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Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp Asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
Jurnal Rumpun Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v5i3.5522

Abstract

Fungal infections are a common health problem in tropical regions, including Indonesia, since humid conditions support microbial growth. Candida tropicalis is a pathogenic species frequently identified as the cause of both superficial and systemic candidiasis. The rising resistance to synthetic antifungal agents such as fluconazole and ketoconazole highlights the need for safer and more effective alternative therapies. Propolis, a resinous substance produced by Trigona sp. bees from various plant sources, contains flavonoids, phenolics, and terpenoids with important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, tannins, and terpenoids in the extract. Antifungal activity testing showed that concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone of 27.93 mm observed at 100% concentration. Statistical analysis using ANOVA confirmed significant differences among treatments. Thus, ethanol extract of Trigona sp. propolis from Balikpapan demonstrates strong potential as a natural antifungal agent. These findings support the use of propolis as a natural-based therapeutic alternative for fungal infections and contribute to the development of herbal pharmaceutical products.
Uji Aktivitas Antijamur Ekstrak Propolis dari Lebah Trigona Sp asal Balikpapan terhadap Candida Tropicalis Muthia Adlina; Indah Woro Utami; Nishia Waya Meray
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i4.3377

Abstract

Fungal infections are common health problems in tropical regions, including Indonesia, because humid environmental conditions support the growth of these microorganisms. Candida tropicalis is the pathogenic fungal species most frequently found, both as the cause of superficial and systemic candidiasis. The increasing resistance to synthetic antifungal drugs, such as fluconazole and ketoconazole, creates the need for alternative therapies that are safer and more effective. Propolis, a resinous substance produced by Trigona bees from various plant sources, is known to contain flavonoids, phenolics, and terpenoids that have important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening showed that the propolis extract contained alkaloids, flavonoids, phenolics, tannins, and terpenoids. The antifungal activity test demonstrated that extract concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone observed at 100% concentration (27.93 mm). Statistical analysis using ANOVA confirmed significant differences among treatments. Therefore, it can be concluded that propolis extract from Trigona bees in Balikpapan has strong potential as a natural antifungal agent. These findings support the utilization of propolis as an alternative natural-based therapy for fungal infections and as a contribution to the development of natural pharmaceutical products.
Co-Authors Indah Woro Utami Meray, Nishia Waya