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All Journal World Nutrition Journal Jurnal Penelitian Farmasi dan Herbal
Wijayanthie, Nadiyah
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Medicine & Pharmacology Public Health

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Vitamin D deficiency and risk of myasthenia gravis: An evidence-based case report Wijayanthie, Nadiyah; Wulandari, Yohannessa; Rahmawati, Anni
World Nutrition Journal Vol. 8 No. i1 (2024): Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0007

Abstract

Background: An autoimmune condition known as myasthenia gravis (MG) targets the receptors for neurotransmitter acetylcholine at the neuromuscular junction, resulting in inhibition of muscle contraction. This results in muscle weakness resulting in a decrease in quality of life. Immunoregulation and muscle contractility are known to play a role in vitamin D. Literature on how vitamin D affects myasthenia gravis risk has not been widely carried out and the results are still controversial.Objective: To evaluate the association between vitamin D and MG risk.Methods: The search of the literature was conducted from PubMed, Cochrane Library, Embase, and EBSCOhost with the eligibility criteria determined by the authors. The literature search was using MeSH Term, text word, and title/abstract.Results: Two articles were selected and critically appraised. The first article shows an odds ratio of 3.96 (CI95 1.26 to 12.52), which means that myasthenia gravis has vitamin D levels almost 4 times lower than healthy population. A case-control study that followed described a comparison of mean levels of vitamin D (25(OH)D) in myasthenia gravis (mean, 18.8±8.4 ng/mL) compared to healthy controls (26.3±6.1). ng/mL) (p <0.05). Both studies revealed a strong interaction between MG and vitamin D inadequacy. Conclusion: Both studies above support the theory that vitamin D deficiency is associated with the risk of developing MG.
Formulation and Acceptability of CelGar Jelly: A Functional Jelly Candy Derived from Garlic and Celery Maratis, Jerry; Syarifah, Syarifah; Huzaen, Saphira Aurelia; Hidayat, Latricia Aina; Nazreen, Amanda Farren; Indah Wardani, Laila Meiliyandrie; Hidayat, Andri Krisna; Pamungkas, Rian Adi; Wijayanthie, Nadiyah
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

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Abstract

Hypertension is a major global health concern due to its often asymptomatic progression and its association with serious complications such as stroke, heart failure, and kidney disease. This study aimed to develop a functional food product, CelGar jelly, formulated from celery (Apium graveolens L.) and garlic (Allium sativum L.), which are traditionally recognized for their potential antihypertensive properties. Three types of tests were conducted to evaluate the product. A hedonic (sensory) test involving 20 untrained panelists assessed consumer acceptance based on color, aroma, taste, and texture using a five-point hedonic scale. Laboratory analysis was performed to determine the moisture and ash content to ensure compliance with food quality standards. In addition, a functional test using a quasi-experimental one-group pretest–posttest design involved 12 respondents with hypertension to evaluate changes in blood pressure before and after the intervention. The results showed that CelGar jelly was generally acceptable to panelists, and the laboratory analysis confirmed that its moisture and ash content met the Indonesian National Standard for jelly candy. The functional test indicated a statistically significant reduction in systolic blood pressure, while no significant change was observed in diastolic blood pressure. These findings suggest that CelGar jelly has potential as a functional food product supporting blood pressure management, although further studies with larger samples are needed to confirm its health benefits
Co-Authors Hidayat, Andri Krisna Hidayat, Latricia Aina Huzaen, Saphira Aurelia Indah Wardani, Laila Meiliyandrie Maratis, Jerry Nazreen, Amanda Farren Rahmawati, Anni Rian Adi Pamungkas Syarifah Syarifah, Syarifah Wulandari, Yohannessa