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All Journal International Journal of Public Health Science (IJPHS) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Plastik Rekonstruksi Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal Jurnal Ners Science Midwifery Jurnal Darma Agung Jurnal Sehat Indonesia (JUSINDO) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Wulandari, Yohannessa
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Global Leadership Initiative on Malnutrition criteria for predicting surgical site infection in elective laparotomy patients Octaviani, Pauline; Wulandari, Yohannessa; Ibrahim, Febiansyah; Andayani, Diyah Eka
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.24175

Abstract

Laparotomy surgery patients are at risk for complication including surgical site infections (SSI) which are associated with high morbidity and mortality. Malnutrition has been identified as a risk factor for the occurrence of SSI but preoperative malnutrition identification remains low. The Global Leadership Initiative on Malnutrition (GLIM) has published a new, practical, and easily applicable definition of malnutrition. This study aims to evaluate whether malnutrition according to GLIM criteria is a predictor of SSI in elective laparotomy patients. This prospective cohort study involved 123 subjects aged 18-65 years undergoing elective laparotomy, without diabetes history. Their malnutrition status was assessed using GLIM criteria with bioelectrical impedance analysis (BIA) to evaluate muscle mass. A total 62 subjects were categorized into the malnutrition group and the remaining into nonmalnutrition group and then monitored for the presence of SSI up to 10 days postoperatively. SSI occurred in 13.8% of the subjects. The analysis showed a strong association between malnutrition and SSI in elective post laparotomy (RR 4.6; 95%CI 1.4-15.1; p=0.005). Malnutrition according to GLIM criteria is a significant predictor of SSI in elective post laparotomy patients.
Role of folic acid supplementation in level of c-reactive protein in metabolic syndrome : evidence based case report Sjarkowi, Anissa Syafitri; Wulandari, Yohannessa; Trismiyanti, Trismiyanti
World Nutrition Journal Vol. 8 No. i1 (2024): Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0003

Abstract

Introduction: The prevalence of metabolic syndrome is increasing, its progression involves an inflammatory response that has an important impact on the initiation, progressivity, and complications of several diseases such as heart disease, stroke, type 2 diabetes mellitus, and cancer. C-reactive protein (CRP) is one of the inflammation markers increased in patients with metabolic syndrome. Folic acid has a role in metabolizing homocysteine and improving endothelial function. There have been many studies conducted, but the results are still inconsistent. Method: Literature searching was conducted using PubMed, Cochrane Library, and Embase databases. MeSH terms, advanced search and eligibility criteria were used for title/abstract screening before journal review. Results: One systematic review and meta-analysis (SR-MA) and one RCT met the PICO and eligibility criteria. The SR-MA found that folic acid administration can reduce CRP level (WMD -0.94 (95% CI -1.56 – 0.32; p=0.00) at a dose of 0.15 mg/day for 12 weeks to 10 mg/day for 2 weeks, while the RCT found an insignificant result. Conclusion: Folic acid supplementation has a potential benefit to decrease CRP levels in metabolic syndrome.
Vitamin D deficiency and risk of myasthenia gravis: An evidence-based case report Wijayanthie, Nadiyah; Wulandari, Yohannessa; Rahmawati, Anni
World Nutrition Journal Vol. 8 No. i1 (2024): Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0007

Abstract

Background: An autoimmune condition known as myasthenia gravis (MG) targets the receptors for neurotransmitter acetylcholine at the neuromuscular junction, resulting in inhibition of muscle contraction. This results in muscle weakness resulting in a decrease in quality of life. Immunoregulation and muscle contractility are known to play a role in vitamin D. Literature on how vitamin D affects myasthenia gravis risk has not been widely carried out and the results are still controversial.Objective: To evaluate the association between vitamin D and MG risk.Methods: The search of the literature was conducted from PubMed, Cochrane Library, Embase, and EBSCOhost with the eligibility criteria determined by the authors. The literature search was using MeSH Term, text word, and title/abstract.Results: Two articles were selected and critically appraised. The first article shows an odds ratio of 3.96 (CI95 1.26 to 12.52), which means that myasthenia gravis has vitamin D levels almost 4 times lower than healthy population. A case-control study that followed described a comparison of mean levels of vitamin D (25(OH)D) in myasthenia gravis (mean, 18.8±8.4 ng/mL) compared to healthy controls (26.3±6.1). ng/mL) (p <0.05). Both studies revealed a strong interaction between MG and vitamin D inadequacy. Conclusion: Both studies above support the theory that vitamin D deficiency is associated with the risk of developing MG.
Efek Suplementasi Magnesium pada Kontrol Glikemik pada Pasien Diabetes Tipe Ii: Evidence-Based Case Report Ribuan, Consistania; Wulandari, Yohannessa
Jurnal Ners Vol. 8 No. 2 (2024): OKTOBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i2.24830

Abstract

Diabetes merupakan salah satu penyebab morbiditas dan mortalitas di dunia terutama di negara dengan penghasilan rendah dan menengah. Pada pasien diabetes melitus tipe II (DMT2) sering terjadi defisit magnesium terutama pada pasien dengan profil kontrol glikemik yang rendah. Magnesium merupakan ion yang esensial, merupakan kofaktor utama pada bebagai reaiksi enzimatik termasuk untuk glikolisis. Magnesium juga terlibat pada regulasi sinyal insulin, ambilan glukosa oleh sel yang dimediasi oleh insulin, dan terlibat dalam sekresi insulin. Sehingga magnesium dapat memperbaiki kontrol glikemik pada pasien DMT2. Studi ini ingin mengetahui efek suplementasi magnesium oral pada kontrol glikemik pasien DMT2. Pencarian literatur dilakukan dengan advanced searching pada PubMed, Cochrane Library. Digunaka MeSH term dan penyaringan terhadap judul/abstrak dengan kriteria eligibilitas sebelum peninjauan jurnal. 6 artikel dipilih berdasarkan kriteria eligibilitas dan relevansi dengan pertanyaan klinis (PICO). Tiga review sistematis dan dua studi RCT menunjukan suplementasi magnesium dapat memperbaiki kontrol glikemik pada pasien DMT2 secara signifikan. Sedangkan satu studi review sistematis menunjukan penurunan gula darah puasa yang tidak signifikan, walaupun terjadi perbaikan HOMA-IR secara signifikan dan penurunan gula darah puasa lebih signifikan pada durasi suplementasi yang lebih panjang, serta kondisi hipomagnesemia. Suplementasi magnesium oral dapat memperbaiki kontrol glikemik pasien DMT2.
PERAN FLAVONOID TERHADAP TNF ALPHA PADA ENDOMETRIOSIS Wardani, Putri Kusuma; Gunarti, Dwirini Retno; Wulandari, Yohannessa
JURNAL DARMA AGUNG Vol 31 No 3 (2023): JUNI
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Darma Agung (LPPM_UDA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46930/ojsuda.v31i3.3454

Abstract

Endometriosis adalah kondisi yang ditandai oleh pertumbuhan jaringan endometrium di luar rahim, yang dapat menyebabkan gejala nyeri panggul dan gangguan reproduksi. Penelitian sebelumnya telah menunjukkan bahwa tingkat sitokin pro-inflamasi, seperti TNF alpha, meningkat pada endometriosis. Flavonoid, senyawa yang ditemukan dalam berbagai tanaman, telah menunjukkan potensi antiinflamasi dan dapat mempengaruhi ekspresi TNF alpha. Oleh karena itu, penelitian ini bertujuan untuk memahami peran flavonoid dalam mengatur TNF alpha pada endometriosis. Tujuan penelitian ini adalah untuk menginvestigasi peran flavonoid terhadap ekspresi TNF alpha pada endometriosis. Penelitian ini menggunakan metode penelitian kualitatif untuk mendapatkan pemahaman mendalam tentang peran flavonoid dalam hubungannya dengan TNF alpha pada endometriosis. Data dikumpulkan melalui studi kepustakaan yang diperoleh melalui Google Schoolar dan PubMed. Hasil penelitian menunjukan bahwa peran flavonoid memiliki peran dalam mengatur produksi dan aktivitas TNF alpha dalam tubuh. Flavonoid dapat menghambat produksi TNF alpha di tingkat sel dengan mengganggu jalur sinyal yang terlibat dalam regulasi produksi sitokin ini. Sehingga dapat disimpulkan bahwa flavonoid memiliki peran penting dalam endometriosis melalui mekanisme anti-inflamasi dan antiangiogenesis sebagai penghambatan ekspresi dan aktivitas TNF alpha, pengendalian pertumbuhan jaringan endometrium, dan regulasi sistem imun.
Nutrition Therapy in Type 2 Diabetic Burn Patient Ramadhania, Dian Araminta; Wardhana, Aditya; Sinaga, Wina; Wulandari, Yohannessa; Daya, Mulianah; Octovia, Lily Indriani
Jurnal Plastik Rekonstruksi Vol. 8 No. 1 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i1.314

Abstract

Summary: Severe burn patients experience pronounced metabolic changes that caused hyperglycemia. Other existing metabolic conditions such as diabetes mellitus may worsen this condition. Early, adequate, and personalized nutrition therapy may result in better glycemic control and prognosis.A 44-year-old male with severe burn injury involving 27,5% total body surface area (TBSA) and type 2 diabetes mellitus (T2DM) was given early and diabetes-specific nutrition therapy to meet the recommended energy and protein needs. Lower carbohydrate contents and higher mono-unsaturated fatty acids (MUFA) were components of diabetes-specific nutrition therapy. Desirable blood glucose levels, a positive trend of albumin levels, and reduced inflammatory markers were achieved while being given this nutrition therapy. Sepsis was not diagnosed in this patient. The patient was discharged from the hospital after an improvement in clinical condition. Hyperglycemia commonly occurs in critically ill patients, especially with pre-existing T2DM. The provision of prompt and personalized nutrition therapy will improve clinical outcomes.
Effect of Zinc Supplementation on Fasting Blood Glucose Control in Burn Injury Patients with Type 2 Diabetes Mellitus: a Case Report Tedjaatmadja, Chintya; Rasyid, Nurhayati M; Wulandari, Yohannessa; Octovia, Lily Indriani; Sinaga, Wina; Wardhana, Aditya
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.194

Abstract

Burn injury is the second leading cause of injury in Indonesia. Patients with burn injury may develop zinc deficiency due to loss of exudate and decreased carrier proteins, leading to impaired glucose regulation and inadequate wound healing. Jayawardena et al. showed that zinc supplementation can help regulate blood glucose in patients with diabetes mellitus. This case aims to see the effect of zinc supplementation on fasting blood glucose control in burn injury patients with type 2 diabetes mellitus. A 47-year-old Male with diabetes mellitus and a history of COVID-19 presented with 34% second to third-degree burn injury. The patient was given short-acting insulin 6 IU thrice a day and long-acting insulin 10 IU once a day. Nutrition was increased gradually until it reached 30 kcal/kgBW with protein 1,2 g/kgBW on the 28th day of hospitalization, referring to a diabetes-specific formula, 6x300 kcal. The patient also received zinc sulfate supplementation, 40 mg per day. The patient’s daily zinc intake was 47 mg/dL, and it was analyzed using Nutrisurvey. Fasting blood glucose in the first 28 days was not well-regulated (92-348 mg/dL). After 28 days of zinc supplementation, the patient's fasting blood glucose was stable. (140-180 mg/dL). Uncontrolled blood glucose leads to bacteremia, decreased skin graft takes, and increased mortality. Zinc deficiency can cause greater insulin resistance that can lead to hyperglycemia. Fasting blood glucose was stable after 28 days of zinc supplementation, similar to the previous study. Supplementation can help to regulate fasting blood glucose in burn patients with diabetes mellitus.
Hubungan Antara Asupan Energi dengan Rasio Neutrofil Limfosit pada Pasien Sakit Kritis Purwantini, Dian; Wulandari, Yohannessa; Sunardi, Diana; Sutanto, Krisadelfa; Sinaga, Wina; Andayani, Diyah Eka
Majalah Kedokteran Indonesia Vol 75 No 2 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.2-2025-1760

Abstract

Introduction: Critically-ill patients experience catabolic stress and inflammatory responses resulting in increased catabolism to meet energy demands. Neutrophil lymphocyte ratio (NLR) is used to assess immune and stress responses. Method: This study was a cross-sectional study of subjects aged ≥18 years admitted to the intensive care unit of Dr. Cipto Mangunkusumo National Central General Hospital and University of Indonesia Hospital. The characteristics of the study subjects included age, gender, nutritional status, diagnosis of ICU admission, protein intake, fat intake, and carbohydrate intake. Bivariate analysis was performed to evaluate the correlation between energy intake and neutrophil-lymphocyte ratio.Result: There were 44 subjects with a median age of 55 years (19-86). Nutritional status based on body mass index (BMI) obtained 31.8% normal nutritional status, 20.5% severe malnutrition, 25% obesity grade 1. The most common diagnoses were surgery and trauma 20.5% of subjects and sepsis 20.5% of subjects. Median RNL was 10.39 (2.51-59.5), energy intake was 10.5 (3-29) kcal/kg BW/day, protein intake was 0.4 (0-1.2) g/kg BW/day, fat intake was 18 (0-29)% and carbohydrate intake was 92 (23-184) g/day.Conclusion: There was no correlation between energy intake and NLR.
The Effectiveness of a High-Protein Liquid Dietary Supplementation in Improving Nutritional Status of Malnourished Patients in Hospital Care: a Preliminary Study Simadibrata, Marcellus; Abdullah, Murdani; Witjaksono, Fiastuti; Muzellina, Virly Nanda; Utari, Amanda Pitarini; Wulandari, Yohannessa; Wijayanti, Ari; Mustikarani, Dewi; Haloho, Raja Mangatur; Rachman, Aditya; Simadibrata, Daniel Martin; Mutiara, Rizka; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.108 KB) | DOI: 10.24871/231202243-51

Abstract

Background: Malnutrition is a very common problem in hospitalized patients. Based on studies conducted in various countries, the prevalence of hospital malnutrition ranges from 20-45%. Hospital malnutrition can occur as a result of insufficient nutrient intake, impaired absorption of nutrients in the gastrointestinal (GI) tract, loss of nutrients due to disease, or increased metabolic requirement during illness. Nutrition is the basis for the healing process as it requires good nutrients through various enzymatic reactions. Some studies have shown that hospital malnutrition increases morbidity, mortality, prolongs the duration of hospitalization, and delays recovery. To improve nutritional status, a high-protein diet can be given. Liquid diet is one of the alternative forms of nutrition because it is easier to swallow.Method: This study was a double-blind randomized controlled trial conducted to assess the effectiveness of high protein liquid dietary supplementation in malnourished hospitalized patients. The patients were assessed for their nutritional status based on ESPEN 2015 criteria. Patients who experienced malnutrition will be divided into 2 groups, namely the control group which was given normal protein liquid diet, while the intervention group was given high protein liquid diet supplementation as much as 2 bottles (200 mL) per day for 7-10 days. Furthermore, the nutritional status of the patient was assessed.Results: By administering high-protein liquid diet supplementation, there was a tendency to increase the strength of the right handgrip in 3 subjects (50%), the tendency to increase body mass index (BMI) in 3 subjects (50%), Subjective Global Assessment (SGA) score improved in 2 subjects with mild/moderate malnutrition (33.3%) and 1 subject with normal nutrition (16.7%), and the tendency to increase the fat-free mass in 3 subjects (50%).Conclusion: The administration of high protein liquid dietary supplementation tended to increase the strength of the right handgrip, BMI, SGA score, and body fat-free mass index.
Superoxide dismutase (SOD) activity in stunted children: Review article Badrya, Leily; Retno Gunarti, Dwirini; Wulandari, Yohannessa
Science Midwifery Vol 12 No 2 (2024): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i2.1581

Abstract

This literature review aims to provide an overview of superoxide dismutase (SOD) activity in stunted children. Method is a literature search was done regarding superoxide dismutase activity in stunting. The literature search utilized PubMed to search for published articles, including clinical trials, case reports, and review articles between 2011 and 2023. The result of stunting is a type of chronic malnutrition caused by long-term malnutrition in children. Malnutrition is the cause of 45% of all deaths in children aged <5 years. Deficiency of macronutrients, especially protein and amino acids, especially leucine and arginine in stunting, can cause a decrease in mTORC1 activation, as a pathway in the body's protein synthesis, especially enzymatic synthesis. Disruption of the mTORC1 pathway due to stunting causes a decrease in the synthesis of enzymatic endogenous antioxidants, especially superoxide dismutase (SOD), followed by an increase in free radical molecules in the body. An imbalance between superoxide dismutase (SOD) and an increase in free radicals in stunted children can create short-term impacts, such as recurrent acute infections. There can also be long-term impacts, namely non-communicable diseases, such as obesity, heart disease, and diabetes mellitus in the future. Conclusion: based on this literature review, it can be concluded that there is a decrease in the synthesis and activity of superoxide dismutase (SOD) found in stunted children.
Co-Authors Adiningrat, Arina Fatharani Aditya Rachman, Aditya Aditya Wardhana Amanda Pitarini Utari Andayani, Diyah Eka Ari Wijayanti Badrya, Leily Daya, Mulianah Diana Sunardi Dwirini Retno Gunarti Fadhilah, Dini Fiastuti Witjaksono Haloho, Raja Mangatur Ibrahim, Febiansyah Kaka Renaldi Marcellus Simadibrata Murdani Abdullah Mustikarani, Dewi Mutiara, Rizka Muzellina, Virly Nanda Octaviani, Pauline Octovia, Lily Indriani Purwantini, Dian Rahmawati, Anni Ramadhania, Dian Araminta Rasyid, Nurhayati M Ribuan, Consistania Simadibrata, Daniel Martin Sjarkowi, Anissa Syafitri Sutanto, Krisadelfa Tedjaatmadja, Chintya Trismiyanti, Trismiyanti Wardani, Putri Kusuma Wijayanthie, Nadiyah Wina Sinaga