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All Journal Nusantara Science and Technology Proceedings Journal of Global Nutrition Media Penelitian dan Pengembangan Kesehatan
Windayani, Komang
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Scoping Review: Potential of Bekul Fruit (Ziziphus jujube Mill.) as an Antidiabetic Agent in Patients with Type 2 Diabetes Mellitus Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4301

Abstract

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (hyperglycemia) caused by damage or abnormalities in insulin production. Pharmacological therapy used as a treatment for diabetes mellitus in some patients has adverse side effects on the body, thus encouraging exploration to use natural ingredients as an alternative therapeutic source in reducing blood glucose. Therefore, a thorough review is needed to summarize scientific data and investigate the potential use of natural ingredients bekul fruit (Ziziphus jujube Mill.) in its role as an antidiabetic agent. This study used a scoping review with 4 databases: Pubmed, ScienceDirect, DOAJ and Google Scholar. The results of the scoping review of 5 scientific articles found that bekul fruit (Ziziphus jujube Mill.) is proven to have bioactive content that is rich in antioxidants such as phenolic/polyphenolic compounds (ferulic acid, caffeic acid, chlorogenic acid), flavonoids (quercetin, rutin, catechin), phytosterols, and inulin which have the potential as antidiabetic agents with different mechanisms of action in reducing blood glucose levels. Conclusion: bekul fruit (Ziziphus jujube Mill.) has the potential to be an alternative nutraceutical diet therapy in patients with diabetes mellitus.
ANALYSIS BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXTRACT BEKUL FRUIT (Ziziphus jujuba Mill.) AS A POTENTIAL NUTRACEUTICAL Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 1 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i1.2350

Abstract

Pemanfaatan bahan alami sebagai terapi diet atau nutrisi dalam mengobati atau mencegah suatu penyakit berkembang sangat pesat. Salah satu bahan alami yang memiliki potensi sebagai agen nutraceutical adalah buah bekul Bali (Ziziphus jujuba Mill.). Saat ini belum banyak bukti empiris terkait potensi nutraceutical yang terdapat pada buah bekul (Ziziphus jujuba Mill.) varietas Bali. Penelitian ini bertujuan untuk mengetahui kandungan senyawa bioaktif dan aktivitas antioksidan yang terdapat dalam ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali. Metode yang digunakan pada penelitian ini yaitu eksploratorik desain dengan sampel menggunakan buah bekul Bali (Ziziphus jujuba Mill.). Penelitian ini dilaksanakan di Laboratorium Penelitian dan Pengujian Terpadu (LPPT) Universitas Gajah Mada pada bulan April 2024. Proses ekstrasi menggunakan metode maserasi dan uji aktivitas antioksidan dilakukan dengan metode DPPH. Penentuan kadar total flavonoid, fenolik dan saponin menggunakan metode spektrofotometer UV-Vis, sedangkan penentuan kadar quercetin menggunakan metode HPLC. Hasil uji aktivitas antioksidan berdasarkan nilai IC50 tergolong kuat yaitu sebesar 78,57%, kandungan senyawa total flavonoid (114,85 mg QE/g), quercetin (60,00 µg/g), fenolik (109,34 mg GAE/g) dan saponin (9,90 mg/g). Dapat disimpulkan bahwa ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali diketahui memiliki kandungan senyawa bioaktif yaitu fenolik, flavonoid dan turunannya seperti quercetin, dan saponin serta memiliki aktivitas antioksidan tergolong kuat yang dapat dimanfaatkan sebagai agen nutraceutical.
Nutritional Care Management of a Pediatric Patient with Stage V Chronic Kidney Disease on Hemodialysis Complicated by Hypertension and Pulmonary Edema with a Differential Diagnosis of Rheumatic Heart Disease Windayani, Komang; Ananda, Kiki Rizky; Ekorinawati, Wiwik; Rusliana, Eka; Windaningrum, Laras Sekar
Journal of Global Nutrition Vol 6 No 1 (2026)
Publisher : Ikatan Sarjana Gizi Indonesia (ISAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53823/jgn.v6i1.200

Abstract

Chronic Kidney Disease (CKD) stage V in pediatric patients requires renal replacement therapy such as hemodialysis and is often accompanied by complications including hypertension and cardiovascular disorders, such as suspected rheumatic heart disease (RHD). These conditions increase the risk of fluid overload, pulmonary edema, and nutritional problems, thus requiring comprehensive nutritional management. This study used a descriptive observational case study design conducted at Dr. Moewardi General Hospital, Surakarta. The subject was selected using purposive sampling based on the risk of malnutrition using the STRONG-kids screening form. Data were collected through interviews, medical records, anthropometric measurements, biochemical and clinical assessments, and a 24-hour food recall. Nutritional care was carried out using the standardized Nutrition Care Process, including assessment, diagnosis, intervention, education, and monitoring for three days. The subject was a 13-year-old pediatric patient with CKD undergoing hemodialysis, presenting with edema, hypertension, and suspected RHD. Dietary intake was inadequate (<70%). Anthropometric assessment based on Mid-Upper Arm Circumference (MUAC) indicated normal nutritional status despite the presence of edema. Biochemical examination showed anemia and increased creatinine and urea levels. Nutritional intervention showed an increasing trend in intake over three days, although energy and carbohydrate intake remained deficient. Clinical parameters, including blood pressure and respiratory rate, showed improvement, along with decreased creatinine and urea levels. Nutritional therapy in the form of a hemodialysis diet and low-sodium diet contributed to improved intake, fluid balance, and clinical outcomes. Sodium restriction played an important role in controlling blood pressure and preventing fluid overload, including the risk of pulmonary edema. Integrated nutritional management combined with hemodialysis improved intake, clinical condition, and biochemical parameters in pediatric CKD patients with hypertension and suspected RHD.
Co-Authors Ananda, Kiki Rizky Ekorinawati, Wiwik Paramasari Dirgahayu Ratih Puspita Febrinasari Rusliana, Eka Windaningrum, Laras Sekar