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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Medika Kartika : Jurnal Kedokteran dan Kesehatan
Islamy, Nabila Nur Bilqis
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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The Effectiveness of Meloxicam Adjuvant Therapy to Improve Cognitive Function of Schizophrenic Patients Islamy, Nabila Nur Bilqis; Nugroho, I Gusti Bagus Indro; Herdaetha, Adriesti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.52-56

Abstract

Highlights:1. Schizophrenic patients have cognitive dysfunction.2. Meloxicam, as an adjuvant therapy, can improve cognitive function in schizophrenic patients. AbstractIntroduction: Schizophrenia is a chronic psychotic disorder triggered by genetic and environmental factors such as an inflammatory response. The inflammatory response in schizophrenic patients increases with cognitive decline. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) group with Cyclo-oxygenase (COX-2) inhibitory activity and can suppress the production of inflammatory cytokines. This study aimed to determine the efficacy of Meloxicam as an adjuvant therapy to improve cognitive function in schizophrenic patients.Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. The sample size in this study was 34 subjects who had met the inclusion and exclusion criteria. All samples were divided into two groups, namely the treatment group, with as many as 17 subjects receiving additional therapy with Meloxicam 15 mg/day for 4 weeks, and the control group, with 17 subjects. The score of the Schizophrenia Cognition Rating Scale (ScoRS) was assessed before and after therapy. Data analysis used SPSS 25.0. In both groups, the SCoRS score was different.Results: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.Conclusion: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.
TELAAH PUSTAKA: STRES, SUMBU OTAK DAN KULIT, DAN VITILIGO Islamy, Nabila Nur Bilqis; Nugroho, I Gusti Bagus Indro
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 4 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Vitiligo merupakan penyakit kulit kronis yang berdampak pada psikologis. Untuk alasan ini, vitiligo dapat memengaruhi kualitas hidup sehingga disabilitas psikiatris tidak boleh diremehkan. Metode penelusuran bukti ilmiah berupa buku dan jurnal. Penelusuran menggunakan buku yang diterbitkan dalam waktu 10 tahun terakhir atau edisi terakhir. Penelusuran literatur jurnal dengan cara pencarian jurnal ilmiah melalui database yang terpercaya dan sering digunakan yaitu Pubmed, Cochrane, Wolters Kluwer, Springer, Karger, dan Science Direct dengan kata kunci yang digunakan yaitu “Stress” AND “Vitiligo” AND “Brain-skin Axis” AND “Psychosocial Impact” dengan filter publikasi jurnal, lima tahun terakhir, dengan jenis prospective cohort, retrospective cohort, systematic review, meta-analysis, dan pilihan bahasa Inggris. Dari hasil penelusuran bukti ilmiah berupa buku dan jurnal, didapatkan lima artikel dalam penelusuran namun ada satu artikel yang didapat hanya berupa overview dan dinilai kurang bisa menjawab pertanyaan klinis sehingga disingkirkan. Hasil akhir penelusuran, terdapat empat jurnal yang sesuai dengan topik mengenai Stress, Brain-skin Axis, dan Vitiligo. Dari hasil telaah literatur, terdapat hubungan terjadinya vitiligo dengan stres dan inflamasi. Psikopatologi yang terjadi pada pasien vitiligo melibatkan hubungan antara brain-skin axis. Selain faktor biologi, terdapat faktor psikososial yang mempengaruhi psikolatologi pada pasien vitiligo, seperti coping, self-esteem, dukungan sosial dan stigmatisasi. Kata kunci: brain-skin axis, dampak psikososial, stres, vitiligo DOI : 10.35990/mk.v6n4.p418-429
Co-Authors HERDAETHA, ADRIESTI Nugroho, I Gusti Bagus Indro