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All Journal Majalah Kedokteran Andalas JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Medika Kartika : Jurnal Kedokteran dan Kesehatan
Nugroho, I Gusti Bagus Indro
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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The Effectiveness of Meloxicam Adjuvant Therapy to Improve Cognitive Function of Schizophrenic Patients Islamy, Nabila Nur Bilqis; Nugroho, I Gusti Bagus Indro; Herdaetha, Adriesti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.52-56

Abstract

Highlights:1. Schizophrenic patients have cognitive dysfunction.2. Meloxicam, as an adjuvant therapy, can improve cognitive function in schizophrenic patients. AbstractIntroduction: Schizophrenia is a chronic psychotic disorder triggered by genetic and environmental factors such as an inflammatory response. The inflammatory response in schizophrenic patients increases with cognitive decline. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) group with Cyclo-oxygenase (COX-2) inhibitory activity and can suppress the production of inflammatory cytokines. This study aimed to determine the efficacy of Meloxicam as an adjuvant therapy to improve cognitive function in schizophrenic patients.Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. The sample size in this study was 34 subjects who had met the inclusion and exclusion criteria. All samples were divided into two groups, namely the treatment group, with as many as 17 subjects receiving additional therapy with Meloxicam 15 mg/day for 4 weeks, and the control group, with 17 subjects. The score of the Schizophrenia Cognition Rating Scale (ScoRS) was assessed before and after therapy. Data analysis used SPSS 25.0. In both groups, the SCoRS score was different.Results: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.Conclusion: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.
The Differences in Adjuvant Therapy Effectiveness Meloxicam and N-Acetylcysteine against Negative Symptoms of Schizophrenia Murda, Banu Kadgada Kalingga; Nugroho, I Gusti Bagus Indro; Herdaetha, Adriesti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.63-69

Abstract

Highlights:1. Schizophrenic patients can have negative symptoms.2. Adjuvant therapy is needed to assist antipsychotics in reducing the negative symptoms of schizophrenic patients. AbstractIntroduction: Meloxicam and N-Acetylcysteine are examples of drugs with anti-inflammatory effects that have been widely studied, and are considered to reduce negative symptoms of schizophrenia. Both of these drugs are also widely available in Indonesia and can be obtained at an affordable price. This study aimed to analyze the differences in the effectiveness of adjuvant therapy meloxicam and N-Acetylcysteine on negative symptoms of schizophrenic patients. Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. Determination of the subject used a purposive sampling technique according to the inclusion criteria. This study examined 34 samples and divided them into two groups. In group A, 17 subjects received adjuvant meloxicam therapy of 15 mg/day for 4 weeks; in group B, 17 subjects received adjuvant therapy of N-Acetylcysteine 400 mg/day for 4 weeks. Score assessment was performed using the positive scale, negative scale, and general psychopathology scale (PANSS) negative subscale pre- and post-therapy, then compared the effectiveness. Data analysis used SPSS 25.0.Results: The mean score of the PANSS post-test subscale was negative in the meloxicam adjuvant therapy group 15.58, while for the N-Acetylcysteine adjuvant therapy group was 17.64 with a p-value of 0.009. The mean decrease in the negative subscale PANSS score in the meloxicam adjuvant therapy group was 11.00, while the N-Acetylcysteine adjuvant therapy group was 19.70 with a p-value of 0.000.Conclusion: There was no difference in the effectiveness of adjuvant therapy meloxicam and N-Acetylcysteine in improving negative symptoms of schizophrenic patients.
Perception of online learning with anxiety and stress level among medical students Dewanti, Nanda Derista Ayu; Nugroho, I Gusti Bagus Indro; Lestari, Anik; Yuliadi, Istar; Ilyas, Muhana Fawwazy; Triniputri, Winastari Yarhanim
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p600-608.2023

Abstract

Objective: This study aimed to find out the association between the perception of online learning and anxiety as well as stress levels among medical students. Methods: This is an observational analytic study with a cross-sectional approach. The sample was comprised of 213 undergraduate medical studentsept at Medical Faculty Universitas Sebelas Maret (UNS) and data were collected using total sampling. The study was conducted using the Taylor Manifest Anxiety Scale (TMAS), Perceived Stress Scale (PSS), and perception of online learning questionnaires. Data were analyzed using Chi-square, Cramer’s V, and Kendall tau b test. Results: This study shows a significant correlation between the perception of online learning and anxiety (p=0.049) as well as stress level (p=0.007). Sex also has an association with anxiety (p=0.010) and stress level (p=0.004). Furthermore, female has higher anxiety and stress levels compared to male. Conclusions: Perception of online learning is related to the anxiety and stress level among medical students.
TELAAH PUSTAKA: STRES, SUMBU OTAK DAN KULIT, DAN VITILIGO Islamy, Nabila Nur Bilqis; Nugroho, I Gusti Bagus Indro
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 4 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitiligo merupakan penyakit kulit kronis yang berdampak pada psikologis. Untuk alasan ini, vitiligo dapat memengaruhi kualitas hidup sehingga disabilitas psikiatris tidak boleh diremehkan. Metode penelusuran bukti ilmiah berupa buku dan jurnal. Penelusuran menggunakan buku yang diterbitkan dalam waktu 10 tahun terakhir atau edisi terakhir. Penelusuran literatur jurnal dengan cara pencarian jurnal ilmiah melalui database yang terpercaya dan sering digunakan yaitu Pubmed, Cochrane, Wolters Kluwer, Springer, Karger, dan Science Direct dengan kata kunci yang digunakan yaitu “Stress” AND “Vitiligo” AND “Brain-skin Axis” AND “Psychosocial Impact” dengan filter publikasi jurnal, lima tahun terakhir, dengan jenis prospective cohort, retrospective cohort, systematic review, meta-analysis, dan pilihan bahasa Inggris. Dari hasil penelusuran bukti ilmiah berupa buku dan jurnal, didapatkan lima artikel dalam penelusuran namun ada satu artikel yang didapat hanya berupa overview dan dinilai kurang bisa menjawab pertanyaan klinis sehingga disingkirkan. Hasil akhir penelusuran, terdapat empat jurnal yang sesuai dengan topik mengenai Stress, Brain-skin Axis, dan Vitiligo. Dari hasil telaah literatur, terdapat hubungan terjadinya vitiligo dengan stres dan inflamasi. Psikopatologi yang terjadi pada pasien vitiligo melibatkan hubungan antara brain-skin axis. Selain faktor biologi, terdapat faktor psikososial yang mempengaruhi psikolatologi pada pasien vitiligo, seperti coping, self-esteem, dukungan sosial dan stigmatisasi. Kata kunci: brain-skin axis, dampak psikososial, stres, vitiligo DOI : 10.35990/mk.v6n4.p418-429
Co-Authors Anik Lestari Dewanti, Nanda Derista Ayu HERDAETHA, ADRIESTI Ilyas, Muhana Fawwazy Islamy, Nabila Nur Bilqis Istar Yuliadi Murda, Banu Kadgada Kalingga Triniputri, Winastari Yarhanim