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All Journal Jurnal Farmasi Kryonaut Jurnal Pengabdian Nasional (JPN) Indonesia
Pasaribu, Cheryl Areta
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Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Inventarisasi dan Pemetaan Keberagaman Tanaman Obat Keluarga di Desa Rambipuji, Kabupaten Jember: Upaya Pelestarian Pengetahuan Lokal Pasaribu, Cheryl Areta; Azzahra, Bazlina Ashi; Sepdianto, Bagas Nur; Wijayanti, Pamelia Agnes; Gutomo, Rafa Bagus; Prayoga , Neisya Azka Putri; Putra, Dimas Arifiansyah; Pangaribowo, Dian Agung
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 5 No. 3 (2024): September
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v5i3.1078

Abstract

This study aims to map the diversity of family medicinal plants (TOGA) in Rambipuji Village, Rambipuji District, Jember Regency, East Java. TOGA is an important component in the lives of Indonesian people as an affordable and easily accessible alternative to traditional medicine. Nonetheless, in Rambipuji Village, the potential of TOGA has not been optimally utilized, and information regarding its geographical distribution is still limited. Therefore, accurate mapping is needed to support the utilization and preservation of TOGA. The research method involved three main stages: preparation, implementation, and map-making. In the preparation stage, the research team consulted with village officials to acquire permission and support. The implementation stage involved collecting coordinate point data of various medicinal plant species in the three main hamlets, namely Gudang Karang, Krajan, and Curah Ancar, utilizing the GPS Map Camera application. This data was later analyzed and imported into the QGIS application for the creation of an interactive map. The resulting map shows that there are 126 coordinate points in Gudang Karang Hamlet, 41 points in Krajan Hamlet, and 32 points in Curah Ancar Hamlet, with a total of 48 different medicinal plant species. The resulting TOGA diversity map provides a clear visual picture of the distribution of medicinal plants in Rambipuji Village, whereby it is expected to become a learning tool for the community and support the preservation and sustainable use of TOGA. This mapping is designed to improve the welfare of the community through a more targeted and coordinated utilization of medicinal plants.
COMPUTATIONAL SCREENING OF KEJIBELING (STROBILANTHES CRISPUS) COMPOUNDS AS KIDNEY STONE PREVENTIVE AGENTS: AI BASED IN SILICO APPROACH Febryanto, Hery Diar; Pasaribu, Cheryl Areta; Raihanah, Cut; Afthoni, M. Hilmi
Jurnal Farmasi Kryonaut Vol 4 No 2 (2025): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v4i2.166

Abstract

Urolithiasis is a chronic and increasingly prevalent condition worldwide, characterized by kidney stone formation due to an imbalance between crystallization promoters and inhibitors in the urinary tract. Strobilanthes crispus (kejibeling) is ethnopharmacologically recognized for its diuretic and anti-urolithiasis effects, yet its molecular mechanisms remain poorly explored. This study aimed to screen bioactive compounds of S. crispus with potential diuretic activity, evaluate their binding affinity to diuretic-related protein targets, and compare them to furosemide as a control. Metabolites were identified through the KNApSAcK database and AI-assisted literature search (ChatGPT 4.0 and Gemini 2.5), followed by drug-likeness evaluation using Lipinski’s rule of five. The diuretic-related targets—CA1, aquaporin, vasopressin receptor, and epithelial sodium channel (ENaC)—were selected based on SwissTargetPrediction, PASS Online, and literature evidence. Molecular docking was performed using PyRx, visualized with Discovery Studio, and validated through analysis of key interacting residues and RMSD. Six main compounds (caffeic acid, apigenin, gallic acid, naringenin, (-)-epicatechin, kaempferol) complied with Lipinski’s criteria. Among these, naringenin, apigenin, (-)-epicatechin, and kaempferol exhibited comparable or superior binding affinities to furosemide at critical residues of the target proteins, with binding energies ranging from -7.3 to -7.9 kcal/mol. Docking visualizations confirmed interactions at residues similar to those of furosemide, supporting the predicted binding sites. RMSD values (<2.5 Å) indicated dynamic stability of the ligand-protein complexes. These findings suggest that S. crispus bioactive compounds, particularly naringenin, apigenin, (-)-epicatechin, and kaempferol, have potential as natural diuretic agents with mechanisms resembling furosemide, supporting their use as herbal preventive therapy for kidney stones.
Co-Authors Afthoni, M. Hilmi Azzahra, Bazlina Ashi Dian Agung Pangaribowo Gutomo, Rafa Bagus Hery Diar Febryanto Prayoga , Neisya Azka Putri Putra, Dimas Arifiansyah Raihanah, Cut Sepdianto, Bagas Nur Wijayanti, Pamelia Agnes