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All Journal e-Journal Pustaka Kesehatan Science and Technology Indonesia IDJP (Indonesian Journal of Pharmaceutics) Journal of Agropharmacy Jurnal Farmasi Galenika
Hery Diar Febryanto
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Optimasi dan Formulasi Tablet Mengapung - Mucoadhesive Glimepirid dengan Kombinasi Polimer Karbopol dan HPMC K4M (Optimization and Formulation Floating - Mucoadhesive Glimepiride Tablet with Combination Carbopol and HPMC K4M) Hery Diar Febryanto; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Glimepiride is one of the preferred drug for the treatment of type II diabetes mellitus. Diabetes can affect gastric emptying time. Incomplete absorption of drugs often result in small bioavailability. Glimepiride was chosen as model drug because it has incomplete absorbtion due to less gastric residence time. Tablet make by direct compression using polymer carbopol, HPMC K4M and other additives. This study used factorial design. Factors that are optimazed are carbopol and HPMC K4M and responses used are floating lag time, floating duration time, mucoadhesive, dan DE 720. tablet were evaluated for invitro release characteristic for 12 hours. Area optimum obtained on the composition of the combination of Carbopol 69.20 to 70.60 mg and HPMC K4M 10.66 to 24.67 mg.   Keywords: glimepiride, floating mucoadhesive tablet, release kinetics, carbopol, HPMC K4M
Solubility Enhancement Methods Of Efavirenz : A Review febryanto, hery diar; Eryani, Mikhania Christiningtyas; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.64166

Abstract

Human Immunodeficiency Virus (HIV) is a global public health concern due to its progression to acquired immunodeficiency syndrome (AIDS) and the associated high morbidity and mortality rates. Efavirenz (EFV), an antiretroviral drug, is widely used to manage HIV/AIDS. However, EFV exhibits poor aqueous solubility and variable bioavailability, necessitating techniques to enhance its solubility and dissolution for improved therapeutic efficacy. This study reviewed methods to enhance EFV solubility using data from research published between 2019 and 2023. Various approaches, including Nano Micelles, Wet Milling, Co-crystals, Physical Mixtures, Nanocrystals, Dry Milling, and Liquisolid techniques, were analysed. The results demonstrated significant solubility enhancements. For instance, Fuentes (2024) achieved a 50% dissolution efficiency using Nano Micelles, while wet milling by Prado (2024) increased dissolution from 83.48% to 99.10% over 150 minutes. Co-crystals, such as those studied by Gowda (2022), improved solubility from 94.16 µg/mL (pure EFV) to 197.32 µg/mL (EFV-DL-Alanine). Sartori's (2022) Nanocrystals technique demonstrated a dissolution efficiency of 98.41%. Furthermore, physical mixtures like Nel's (2022) combination of EFV with pea protein isolate achieved a solubility increase from 1.00 mg/mL to 2.30 mg/mL. These methods highlight advancements in solubility enhancement techniques that improve EFV’s pharmacokinetic profile. These findings can guide the development of more effective pharmaceutical formulations, improving treatment outcomes for individuals living with HIV/AIDS.
Optimasi Moringa Gum dan Hidroksi Propil Metil Selulosa dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Sari, Lusia Oktora Ruma Kumala; Hanif, Mohammad Ainul Fakhruddin; Irawan, Eka Deddy; Winarti, Lina; Barikah, Kuni Zu’aimah; Rosyidi, Viddy Agustian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Moringa gum is a natural polymer obtained from Moringa oleifera plant and has been used as a stabilizer, binder, disintegrant, and controlled release matrix. Moringa gum has a polyuronide group, which can potentially be a mucoadhesive agent. This study used moringa gum as a mucoadhesive agent in diltiazem HCl mucoadhesive buccal film. This research aimed to determine the effect of the combination of moringa gum and HPMC on surface pH, swelling index, and in-vitro mucoadhesive residence time. Mucoadhesive buccal films were evaluated for weight and thickness uniformity, folding resistance, drug content, surface pH, swelling index, in-vitro mucoadhesive residence time, and characterization in the form of FTIR and release studies. All formulations met the tests of uniformity of weight and thickness, folding resistance, and drug content. The results showed FB as the optimum formula with a surface pH of 5.803±0.101, a swelling index of 7.031±0.134, and a residence time of 505.67±4.51 minutes. FTIR showed no interaction, and the release study showed 82.197±1.178% release at 480 minutes. In conclusion, a combination of moringa gum and HPMC mucoadhesive buccal film has been successfully prepared with moringa gum as a mucoadhesive agent that increases the residence time.
Pengembangan Sediaan Losio Ekstrak Buah Naga Putih Husni, Patihul; Budianto, Muhamad Oke; Baitariza, Ardian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.419

Abstract

White dragon fruit (Hylocereus undatus) is a tropical fruit from a type of cactus plant that contains various powerful antioxidants. The purpose of this study was to obtain the best lotion formula containing extract of white dragon fruit based on physical evaluation. Three lotion formulas (F1, F2, F3) containing 7,5% white dragon fruit extract were prepared in this study. Physical assessment of the lotion preparation included organoleptic tests, homogeneity, pH determination, and viscosity evaluation. The results showed that the preparation was in the form of a liquid and homogeneous lotion with a white color and a rose odor. The pH of the preparation was around 5.2-6.5 with a viscosity between 1200-1800 cps. F3 is the best lotion formula based on physical evaluation during four weeks of storage with a composition of 7.5% white dragon fruit extract, 1% glycerin, 0.05% triethanolamine, 3% liquid paraffin, 0,3% methyl paraben, 2% dimethicone, 2% stearyl alcohol, 1.5% glycerol monostearate, 3% virgin coconut oil, 0.1% disodium edetate, 3% cetyl alcohol, 0.2% titanium dioxide, parfum qs, and aquadest ad 100%.
Optimization of Hydrolyzed Pumpkin (Cucurbita Moschata) Starch as Natural Superdisintegrant in Promethazine HCl Sublingual Tablets Winarti, Lina; Asrofi, Muhammad; Lubis, Maralodia Almira; Lestari, Tirtawati Putri; Sari, Lusia Oktora Ruma Kumala; Irawan, Eka Deddy; Febryanto, Hery Diar; Afthoni, Muhammad Hilmi; Eryani, Mikhania Christiningtyas
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.502-514

Abstract

Acid hydrolysis of pumpkin starch is a feasible strategy for developing novel pharmaceutical excipients, particularly natural superdisintegrants for sublingual and orally disintegrating tablet formulations. Given the requirement for extremely rapid tablet disintegration in sublingual dosage forms, selecting an efficient disintegrant is a critical formulation parameter. However, native pumpkin starch exhibits limited disintegration efficiency and generally requires high concentrations, which may adversely affect tablet hardness and friability. This study aimed to optimize the acid hydrolysis process of pumpkin starch and to evaluate the performance of the optimized hydrolyzed starch as a natural superdisintegrant in Promethazine HCl sublingual tablets. A factorial design was used to examine the impact of varying hydrolysis durations (3-9 days) and hydrochloric acid concentration (5-9%) on the physicochemical characteristics of the modified starch. The optimized hydrolyzed starch demonstrated a near-neutral pH (5.17 ± 0.03), acceptable moisture content (LOD 10.20 ± 0.44%), and excellent flow properties, as indicated by a low angle of repose (23.96°) and Carr’s index (9.99%). Scanning electron microscopy revealed increased surface irregularity and porosity, while FTIR analysis indicated enhanced exposure of hydroxyl groups, consistent with partial depolymerization of the starch polymer. The amylose content increased to 35.17%, accompanied by improved water uptake and swelling capacity. The effective pore radius (25.03 ± 0.35 µm) and swelling index (70.25 ± 0.57) were markedly higher than those of native pumpkin starch (12.27 µm and 44.30 ± 0.85, respectively), although slightly lower than crospovidone (27.65 µm and 99.97 ± 0.13). Incorporation of the hydrolyzed starch into Promethazine HCl sublingual tablets resulted in formulations with adequate mechanical strength (hardness 3.35 ± 0.05 kg), low friability (0.53 ± 0.04%), rapid disintegration (49.18 ± 0.75 s), and high drug release (96.79 ± 0.13%). These performances were comparable to those of crospovidone and superior to formulations containing native pumpkin starch. The improved tablet characteristics were primarily attributed to enhanced porosity and swelling capacity induced by acid hydrolysis. Overall, optimized hydrolyzed pumpkin starch demonstrates considerable potential as a sustainable, biodegradable, and cost-effective natural superdisintegrant for fast-disintegrating pharmaceutical tablet formulations.
Co-Authors Ardian Baitariza, Ardian Barikah, Kuni Zu’aimah Budianto, Muhamad Oke Eka Deddy Irawan Eryani, Mikhania Christiningtyas Hanif, Mohammad Ainul Fakhruddin Januarti, Melinda Lestari, Tirtawati Putri Lina Winarti Lubis, Maralodia Almira Lusia Oktora Ruma Kumala Sari Muhammad Asrofi, Muhammad Patihul Husni Viddy Agustian Rosyidi