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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi Al-Kimia BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Nasional (JPN) Indonesia Borneo Journal of Pharmacy Journal of Agropharmacy
Dian Agung Pangaribowo
Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA Pangaribowo, Dian Agung
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)- 1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.
Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Abstract

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.
MOLECULAR DOCKING, SINTESIS dan UJI AKTIVITAS SITOTOKSIK Dian Agung Pangaribowo
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 2 No 1 (2014)
Publisher : Magister Program of Applied Chemistry, Udayana University, Bali-INDONESIA

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Abstract

ABSTRAK: Senyawa 1-benzoil-1,3-dimetilurea telah dirancang, disintesis, diidentifikasi struktur, dan diuji aktivitas sitotoksik secara in vitro. Simulasi docking dilakukan dengan memposisikan senyawa ke dalam sisi aktif reseptor Checkpoint kinase 1 (Chk1) untuk menentukan model pengikatan ligan reseptor. Sintesis 1-benzoil-1,3-dimetilurea dilakukan lewat reaksi asilasi antara 1,3-dimetilurea dan benzoil klorida. Kemurnian produk hasil sintesis ditentukan dengan metode Kromatografi Lapis Tipis (KLT). Identifikasi struktur dilakukan dengan spektrofotometer UV, FT-IR dan spektrometer NMR. Hasil uji antiproliferatif menunjukkan bahwa senyawa 1-benzoil-1,3-dimetilurea memiliki aktivitas sitotoksik terhadap sel HeLa yang lebih baik dibandingkan dengan kontrol positif. Senyawa 1-benzoil-1,3-dimetilurea dengan aktivitas sitotoksik dapat menjadi agen antikanker yang potensial. Kata kunci: 1-benzoil-1,3-dimetilurea, molecular docking, aktivitas sitotoksik ABSTRACT: A novel 1-benzoyl-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-benzoyl-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and benzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent. Keywords: 1-benzoyl-1,3-dimethylurea, molecular docking, cytotoxic activity
Label Pintar untuk Pemonitoran Kesegaran Daging Ayam pada Kemasan Novialda Nitiyacassari; Bambang Kuswandi; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.10974

Abstract

Chicken meat is one of the commodities consumed by most Indonesian people and has a pH range of 5,5 – 6,0. The smart label has been applied as a chicken meat freshness detector. As dual indicator freshness, two pH indicators have been used, i.e., bromothymol blue (BTB) and methyl red (MR). The objective of this research was to determine chicken meat freshness using a smart label at room temperature. The color change of the smart label was examined by ImageJ software to determine freshness degree using the mean RGB value. The chicken meat was examined every 2 hours for pH and TVB analysis during the 24 hours storage at room temperature. The result showed that color indicator would change according to chicken meat freshness, BTB turned from yellow to blue (mean RGB 210,591 ± 0,376), and MR turned from red to yellow (mean RGB 208,146 ± 0,390). Chicken meat freshness at room temperature decreased as pH increase from 5,68 to 6,11 along with a color change of smart label. Furthermore, the color would change when 0.022 %N of TVB has been reached. Therefore, chicken meat freshness can be determined by using a smart label based on a dual indicator of bromothymol blue and methyl red at room temperature.
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4- Trifluorometilbenzoiloksimetil)-5-Fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Assay of 1-(4- Trifluoromethylbenzoyloxymethyl)-5-Fluorouracil) On MCF-7 Breast Cancer Cell Puspita Arum Wijayanti; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil (TFU) is a derivative compound of anticancer agent, 5-fluorouracil (5-FU). TFU has been synthesized by Ernawati to increase the anticancer activity of 5-FU. However, the cytotoxic and antiproliferative effect of TFU had not been carried out. This study aimed to evaluate the cytotoxic and antiproliferative activity of TFU compared to 5-FU on MCF-7 breast cancer cell line using MTT method. The citotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The cytotoxic effect was determined based on IC50 value while the antiproliferative effect was determine based on the doubling time value. The results showed that TFU had better cytotoxicity on MCF-7 with IC50 value 401.03 ± 0.370 µM compared to 5-FU with IC50 value 4216.32 ± 800.28 µM. The doubling time value of TFU at concentration of ½ IC50, IC50, and 1½ IC50 were 359.66; 364.39; and 448.40 hours respectively, while 5-FU were 184.45; 214.00; and 220.63 hours. The doubling time value indicated that TFU compound was able to prolong the doubling time of MCF-7 cell line compared to 5-FU. Keywords: cancer, cytotoxicity, proliferation,1-(4-trifluoromethylbenzoyloxymethyl)-5-fluorouracil, MCF-7
Sintesis dan Uji Aktivitas Antibakteri Senyawa N-Fenil-3,4-Diklorobenzamida (Synthesis and Antibacterial Activity Assay of N-Phenyl-3,4-Dichlorobenzamide) Vinastika Gita Yualanda; Indah Purnama Sary; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6610

Abstract

In this research, the synthesis of N-phenyl-3,4-diklorobenzamida was carried out by reacting 1,3-diphenylthiourea and 3,4-dichlorobenzoil chloride via bimolecular nucleophilic substitution reaction (SN2). The assays for the obtained compound product were purity test (tested by TLC and melting point tester), chemical and physical characterization (shape, color, and solubility), confirmation of the compound and structure (performed by UV-Vis spectrophotometer, FTIR spectrometer, 1H-NMR and 13C-NMR). The result showed that the compound was synthesized successfully with a yield of 42%, then the in vitro test of antibacterial activity against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 27853 was conducted by well diffusion method. The compound N-phenyl-3,4-dichlorobenzamida did not have antibacterial activity which showed by the absence of inhibition diameter. Keywords: 1,3-diphenylthiourea, N-phenyl-3,4-dichlorobenzamide, nucleophilic substitution, antibacterial
Uji Sitotoksisitas dan Proliferasi Senyawa 1-(4-nitrobenzoiloksi- metil)-5-fluorourasil terhadap Sel Kanker Payudara MCF-7 (Cytotoxicity and Proliferation Studies of 1-(4-nitrobenzoyloxy- methyl)-5-fluorouracil) on Breast Cancer Cells MCF-7) Eka Mustika Wati; Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

1-(4-nitrobenzoyloxymethyl)-5-fluorouracil (4-NFU) is a derivative of anticancer drug 5-fluorouracil (5-FU) which has been substituted by alkyl, ester, benzene, and nitro groups at N1 position. 4-NFU has been synthesized by Kurnia but anticancer study has not been reported. This research aims to compare the cytotoxicity and antiproliferative activity between 4-NFU and 5-FU on MCF-7 cells. The cytotoxicity and antiproliferative activity were studied by MTT method. The cytotoxicity study was done for 24 hours. The antiproliferative study was done for 24, 48, and 72 hours. The result showed that cytotoxicity activity of 4-NFU (IC50 = 134.039 μM) was higher than 5-FU (IC50 = 4211.508 μM) on MCF-7 cells. Based on the unpaired t test, there was a significant difference between IC50 of 4-NFU and 5-FU (α<0.05). The antiproliferative study showed that there was a growth inhibition on MCF-7 cells. The doubling time value of 4-NFU was 290.51 hours at ½ IC50; 350.97 hours at IC50; and 418.2 hours at 1½ IC50. The doubling time value of 5-FU was 185.99 hours at ½ IC50; 214 hours at IC50; and 220.63 hours at 1½ IC50. The doubling time value of 4-NFU was higher than 5-FU so that antiproliferative activity of 4-NFU was higher than 5-FU on MCF-7 cells. Keywords: 1-(4-nitrobenzoyloxymethyl)-5-fluorouracil, cytotoxicity, proliferation, MCF-7
Optimasi Sintesis Asam 3-benzamido-4-metil benzoat (Optimization Synthesis 3-benzamido-4-Methyl Benzoic Acid) Muh Agus Mauluddin; Dian Agung Pangaribowo; Indah Purnama Sa\
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5888

Abstract

Benzoic acid derivative has been developed as new drugs that have antioxidant, antifungal, analgesic, anti-cancer, anti-inflammatory, and anti-herpes simplex virus activity. In this study, a new compound of benzoic acid derivative, 3-benzamido-4-methyl benzoic acid (3-BM) was synthesized by reacting 3-amino-4-methyl benzoic acid with benzoyl chloride. This study used benzoylation reaction with Schotten-Baumann method. Temperature, time, and TLC mobile phase were needed to be optimized to make optimum condition, so the synthetis reaction can be done. The reaction time was 24 hours, the samples were taken at 1,2,3,4,5,6,12,24 hours then spotted on TLC plates and eluated with optimum eluent chloroform: ethyl acetate: acetic acid (100:5:1). 3-BM compound can be synthesized by benzoylation reaction with optimum synthesis condition at room temperature 25-27 °C and 2 hours reaction time. Keywords: synthesis, benzoic acid derivative, 3-benzamido-4-methyl benzoic acid, benzoyl chloride
MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3- DIMETILUREA Dian Agung Pangaribowo
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)- 1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.
Sosialisasi dan Pelatihan Pembibitan serta Pembudidayaan TOGA (Tanaman Obat Keluarga) di Desa Rambipuji, Kabupaten Jember Nayla, Maulidya Putri; Aulia, Donabella Shefa; Utomo, Wahyu Priyo; Yaqin, Mohammad Ainul; Jamila, Nur Lailatul; Azzahro, Elok Zakiya; Tyascahyani, Callysta Vindi; Pangaribowo, Dian Agung
Jurnal Pengabdian Nasional (JPN) Indonesia Vol. 5 No. 3 (2024): September
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpni.v5i3.1075

Abstract

Rambipuji Village is one of the villages in Rambipuji Sub-district, Jember Regency, with the potential for medicinal plants (TOGA) cultivated by the community in their home gardens. However, several issues hinder the cultivation process of TOGA among the residents, including the limited variety of TOGA plants, the potential of TOGA being uncharted, and the cultivation not being done optimally and sustainably. The SEMILIR program emerges as a solution through outreach and training activities to enhance residents' understanding of TOGA seedling and cultivation. The research method used includes material presentation sessions, TOGA seedling practices, and concludes with a post-test to measure the target group’s understanding. The results of this program show a significant increase in understanding of TOGA seedling and cultivation among 22 participants, or 99.09% of the total participants. This activity not only provided new knowledge but also practical skills that can improve family health and nutrition quality. The program is essential to be sustained in the future, as it has the potential to raise public awareness about health.
Co-Authors Al Yazid, Moch. Khofi Ari Satia Nugraha Aulia, Donabella Shefa Ayik Rosita Puspaningtyas1 Azzahra, Bazlina Ashi Azzahro, Elok Zakiya Bambang Kuswandi Dewi, Tyas Cahya Dwi Koko Pratoko Dyanshah, Danny Agus Eka Mustika Wati Esti, Putri Annora Fathunnisa, Fathunnisa Fifteen Aprila Fajrin Firdausy, Camelia Puspita Gutomo, Rafa Bagus Himmah, Anisatul Indah Purnama Sary Indah Purnama Sary, Indah Purnama Indah Purnama Sa\ Jamila, Nur Lailatul Lestyo Wulandari Mohammad Ainul Yaqin, Mohammad Ainul Muh Agus Mauluddin Nabilah, Arfan Nayla, Maulidya Putri Nia Kristiningrum Novialda Nitiyacassari Nurud Diniyah Nurwijayanti Pasaribu, Cheryl Areta Prayoga , Neisya Azka Putri Puspita Arum Wijayanti Putra, Dimas Arifiansyah Putri, Rinad Alamanda Sallama, Solihatus Sepdianto, Bagas Nur Syaifullah, Abim Tyascahyani, Callysta Vindi Utomo, Wahyu Priyo Vinastika Gita Yualanda Wardhani, Firdha Aprillia Wijayanti, Pamelia Agnes