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All Journal Scientific Journal of Dermatology and Venereology Sriwijaya Journal of Forensic and Medicolegal Scientific Journal of Pediatrics Sriwijaya Journal of Internal Medicine Crown: Journal of Dentistry and Health Research
Rinna Azrida
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

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Molecular Epidemiology of Tinea Pedis Among Palm Oil Plantation Workers in Labuhan Batu Utara Regency, Indonesia: Identification of Causative Fungal Pathogens Haryani, Sela; Riri Arisanty Syafrin Lubis; Rinna Azrida
Scientific Journal of Dermatology and Venereology Vol. 1 No. 2 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.5

Abstract

Introduction: Tinea pedis, commonly known as athlete's foot, is a prevalent fungal infection affecting the feet. Palm oil plantation workers, often exposed to humid and warm conditions, are at an increased risk of contracting this condition. This study aimed to investigate the molecular epidemiology of tinea pedis among palm oil plantation workers in Labuhan Batu Utara Regency, Indonesia, and identify the causative fungal pathogens. Methods: A cross-sectional study was conducted among palm oil plantation workers in Labuhan Batu Utara Regency. Demographic data and clinical information were collected through questionnaires. Skin scrapings were obtained from the affected areas of the feet and subjected to microscopic examination and fungal culture. Molecular identification of the isolated fungi was performed using DNA sequencing of the internal transcribed spacer (ITS) region. Results: A total of 250 palm oil plantation workers participated in the study. The prevalence of tinea pedis was found to be 42.8%. The most common clinical presentations were interdigital scaling and maceration (65.2%), followed by vesicular lesions (23.1%) and hyperkeratosis (11.7%). The predominant fungal pathogens identified were Trichophyton rubrum (58.3%), Trichophyton mentagrophytes (27.8%), and Epidermophyton floccosum (13.9%). Conclusion: Tinea pedis is a significant health problem among palm oil plantation workers in Labuhan Batu Utara Regency. The identification of the causative fungal pathogens is crucial for implementing effective preventive and therapeutic measures to control the spread of this infection.
Non-Invasive Neuromodulation for Drug-Resistant Epilepsy in Children: A Randomized Controlled Trial of Transcranial Magnetic Stimulation (TMS) versus Vagus Nerve Stimulation (VNS) in Jakarta, Indonesia Febria Suryani; Rinna Azrida; Linda Purnama; Vania Delma; Desiree Montesinos
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.173

Abstract

Introduction: Drug-resistant epilepsy (DRE) significantly impacts the quality of life in children. While vagus nerve stimulation (VNS) is an established treatment, repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive alternative. This study aimed to compare the efficacy and safety of rTMS versus VNS in a pediatric DRE population in Jakarta, Indonesia. Methods: This was a single-center, randomized, controlled, open-label trial conducted at Private Hospital, Jakarta. Children aged 5-18 years with DRE, defined as failure to achieve seizure freedom despite adequate trials of two appropriate antiepileptic drugs (AEDs), were randomly assigned (1:1) to receive either rTMS or VNS. The primary outcome was the percentage reduction in seizure frequency at 6 months post-intervention compared to baseline. Secondary outcomes included responder rate (≥50% seizure reduction), quality of life (QoL) using the PedsQL, cognitive function (using standardized neuropsychological tests), and adverse events. Results: A total of 60 children were randomized (30 rTMS, 30 VNS). At 6 months, the mean percentage reduction in seizure frequency was significantly greater in the rTMS group (48.5%, SD 15.2%) compared to the VNS group (35.2%, SD 12.8%) (p = 0.001). Responder rates were 63.3% for rTMS and 46.7% for VNS (p = 0.17). PedsQL scores showed a significant improvement in the rTMS group compared to baseline in the psychosocial health summary score (p = 0.005), but not the VNS group (p=0.1). No significant differences were observed in cognitive function between the groups. Adverse events were generally mild and transient in both groups, though VNS was associated with more voice alteration and coughing. Conclusion: rTMS demonstrated superior efficacy in reducing seizure frequency compared to VNS in this Indonesian pediatric DRE population. While VNS is an established method, rTMS may present a non-invasive and potentially more effective therapeutic alternative. Further, larger, multicenter studies are warranted to confirm these findings and explore long-term outcomes.
Cardiovascular Risk Stratification in Pregnant Women with Gestational Diabetes: A Comparative Analysis of Predictive Models in Padang, Indonesia Cinthya Callathea; Vania Delma; Muhammad Rusli; Bjorka Alma; Rinna Azrida
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.177

Abstract

Introduction: Gestational diabetes mellitus (GDM) significantly increases the risk of both short-term and long-term cardiovascular disease (CVD) in women. Effective risk stratification during pregnancy is crucial for targeted interventions. This study aimed to compare the performance of established cardiovascular risk prediction models in a cohort of pregnant women with GDM in Padang, Indonesia. Methods: A prospective cohort study was conducted involving 350 pregnant women diagnosed with GDM at two major hospitals in Padang, Indonesia, between January 2022 and June 2023. Baseline demographic, clinical, and laboratory data were collected. Three established CVD risk prediction models – the Framingham Risk Score (FRS), the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Equations (PCE), and a modified version of the PCE adapted for GDM (PCE-GDM) – were applied to calculate individual 10-year CVD risk scores. The primary outcome was the development of any major adverse cardiovascular event (MACE), defined as myocardial infarction, stroke, or cardiovascular death, or new-onset hypertension requiring medication, within one year postpartum. Model performance was assessed using discrimination (c-statistic) and calibration (Hosmer-Lemeshow goodness-of-fit test). Results: The mean age of participants was 32.4 ± 5.1 years. The prevalence of pre-existing hypertension was 8.6%, and the mean pre-pregnancy BMI was 28.5 ± 4.7 kg/m². During the one-year follow-up, 25 (7.1%) women experienced a MACE. The PCE-GDM model demonstrated the best discrimination (c-statistic = 0.82, 95% CI 0.76-0.88), followed by the PCE (c-statistic = 0.75, 95% CI 0.68-0.82), and the FRS (c-statistic = 0.68, 95% CI 0.60-0.76). The PCE-GDM also showed good calibration (χ² = 8.3, p = 0.41), while the FRS and PCE tended to underestimate risk (χ² = 18.5, p = 0.02 and χ² = 15.2, p = 0.06, respectively). Conclusion: The PCE-GDM model, specifically adapted for GDM, showed superior performance in predicting short-term cardiovascular risk compared to traditional models in this Indonesian cohort. These findings highlight the need for GDM-specific risk stratification tools to improve cardiovascular risk management in this vulnerable population.
Factors Affecting the Incidence of Tinea Pedis in Palm Oil Plantation Workers in Sonomartani Village, Kualuh Hulu District, Labuhan Batu Utara Regency, Indonesia Haryani, Sela; Riri Arisanty Syafrin Lubis; Rinna Azrida
Scientific Journal of Dermatology and Venereology Vol. 1 No. 1 (2023): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v1i1.194

Abstract

by humid conditions, greatly affects the high incidence of tinea pedis in oil palm workers. This cannot be separated from minimal knowledge about the importance of keeping feet clean while working. This study aimed to determine the factors that influence the incidence of tinea pedis in oil palm plantation workers in Sonomartani Village, Kualuh Hulu District, Labuhan Batu Utara Regency, Indonesia. Methods: Cross-sectional observational study. A total of 48 research subjects participated in this study. Observations on sociodemographics and factors of the risk of developing tinea pedis were carried out in this study. Data analysis was carried out using SPSS univariate and bivariate. Results: The results of the study showed that age <35 years and female gender were associated with the incidence of tinea pedis, p<0.05. Personal hygiene factors such as using their own towels, washing feet after activities, and the habit of drying shoes after use are associated with the incidence of tinea pedis, p<0.05. Conclusion: The habit of washing feet and keeping shoes dry is a factor risk that contributes to the incidence of tinea pedis in oil palm plantation workers in Sonomartani Village, Kualuh Hulu District, Labuhan Batu Utara Regency, Indonesia.
Forensic DNA Phenotyping for Predicting Externally Visible Characteristics in Indonesian Populations: A Novel Tool for Criminal Investigations Rinna Azrida; Febria Suryani; Bjorka Alma; Sony Sanjaya; Khairiel Anwar
Sriwijaya Journal of Forensic and Medicolegal Vol. 2 No. 2 (2024): Sriwijaya Journal of Forensic and Medicolegal
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjfm.v2i2.190

Abstract

Introduction: Forensic DNA phenotyping (FDP) is an emerging field that utilizes genetic information to predict an individual's externally visible characteristics (EVCs). While its application has shown promise in aiding criminal investigations globally, its utility within the diverse Indonesian population remains largely unexplored. This study aimed to investigate the potential of FDP for predicting EVCs in a representative sample of the Indonesian population, evaluating its accuracy and implications as a novel tool for criminal investigations in this unique context. Methods: This study involved the analysis of anonymized DNA samples from 1000 individuals self-identified as belonging to various ethnic groups across Indonesia. A panel of single nucleotide polymorphisms (SNPs) known to be associated with EVCs including hair color, eye color, skin pigmentation, and biogeographic ancestry (BGA) was selected based on existing literature. Genotyping data was generated to reflect the genetic diversity observed in Indonesian populations. Statistical analyses were performed to assess the predictive power of the SNP panel for each EVC and to evaluate the correlation between predicted phenotypes and self-reported characteristics. Results: The results demonstrated a moderate to high predictive accuracy for several EVCs within the Indonesian population. Skin pigmentation showed the highest predictability, followed by eye color and hair color. BGA prediction effectively clustered individuals based on their genetic profiles, aligning with the known population structure of Indonesia. Significant variations in allele frequencies for EVC-associated SNPs were observed across different ethnic groups, highlighting the importance of population-specific data. Conclusion: This study provides preliminary evidence suggesting that forensic DNA phenotyping holds significant potential as a novel tool for criminal investigations in Indonesia. The ability to predict EVCs from DNA could provide valuable leads in cases where traditional DNA profiling yields no matches. However, further research with real Indonesian population data is crucial to validate these findings and to develop robust, population-specific FDP models. Ethical and legal considerations surrounding the use of this technology in the Indonesian context must also be carefully addressed.
In Vitro and In Vivo Efficacy of a Novel Strontium-Doped Bioactive Glass Hydrogel for Dentin-Pulp Complex Regeneration Rinna Azrida; Bryan Helsey; Bernadette Wilson; Mohammad Yoshandi
Crown: Journal of Dentistry and Health Research Vol. 3 No. 1 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i1.236

Abstract

Introduction: The regeneration of the dentin-pulp complex is a major challenge in vital pulp therapy. This study aimed to develop and evaluate a novel injectable hydrogel composed of strontium-doped bioactive glass (Sr-BG) in a methacrylated gelatin (GelMA) matrix to promote dentin-pulp complex regeneration. Strontium was added for its dual therapeutic effects of enhancing odontogenic differentiation and inhibiting bacterial activity. Methods: We synthesized Sr-BG nanoparticles using a sol-gel method and characterized them with X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The nanoparticles were then incorporated into a GelMA hydrogel. We assessed the material's physical properties, including its swelling ratio, degradation rate, and ion release profiles (Si, Ca, P, Sr). We also evaluated its in vitro biocompatibility and odontogenic potential using human dental pulp stem cells (hDPSCs), assessing cell viability (MTT assay), alkaline phosphatase (ALP) activity, and the expression of odontogenic markers (DSPP, DMP-1, RUNX2) via RT-qPCR. We tested its antibacterial properties against Streptococcus mutans. For the in vivo evaluation, the hydrogel was used as a pulp capping agent in the mechanically exposed molars of Wistar rats. After 4 and 8 weeks, we assessed tissue regeneration using histological analysis (H&E and Masson's trichrome staining) and micro-computed tomography (micro-CT). Results: The synthesized Sr-BG nanoparticles were amorphous with a particle size of about 80-120 nm. The Sr-BG/GelMA hydrogel exhibited controlled swelling and degradation, along with a sustained release of therapeutic ions. In vitro, the hydrogel demonstrated excellent biocompatibility and significantly upregulated ALP activity and the expression of DSPP, DMP-1, and RUNX2 in hDPSCs compared to the control group (p < 0.05). The material also showed significant antibacterial activity against S. mutans. In vivo, histological analysis revealed the formation of a thick, continuous, and well-organized tertiary dentin bridge with minimal inflammation in the Sr-BG/GelMA group at 8 weeks. Micro-CT analysis confirmed a significantly greater volume and density of newly formed mineralized tissue compared to control groups treated with calcium hydroxide. Conclusion: The novel strontium-doped bioactive glass hydrogel showed significant potential for dentin-pulp complex regeneration. Its combined osteoinductive, angiogenic, and antibacterial properties make it a promising biomaterial for advanced vital pulp therapy, offering a superior alternative to traditional pulp capping agents.
Co-Authors Bernadette Wilson Bjorka Alma Bryan Helsey Cinthya Callathea Desiree Montesinos Febria Suryani HARYANI, SELA Khairiel Anwar Linda Purnama Mohammad Yoshandi Muhammad Rusli Riri Arisanty Syafrin Lubis Sony Sanjaya Vania Delma