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All Journal Scientia Psychiatrica Sriwijaya Journal of Surgery Sriwijaya Journal of Forensic and Medicolegal Sriwijaya Journal of Obstetrics and Gynecology Sriwijaya Journal of Neurology Crown: Journal of Dentistry and Health Research
Sony Sanjaya
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

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Beyond Amyloid: Investigating the Role of Tau Oligomers in Alzheimer's Disease Progression in Medan, Indonesia Sony Sanjaya; Brenda Jaleel; Cindy Susanti; Yi-Fen Huang; Husin Sastranagara; Agnes Mariska
Sriwijaya Journal of Neurology Vol. 1 No. 2 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.26

Abstract

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory impairment. While amyloid plaques have been a central focus of AD research, increasing evidence suggests that tau oligomers play a crucial role in disease progression. This study aimed to investigate the relationship between tau oligomers, cognitive function, and disease severity in AD patients in Medan, Indonesia. Methods: An observasional case series study was conducted involving 50 AD patients diagnosed according to the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria. Cerebrospinal fluid (CSF) samples were collected and analyzed for tau oligomers using an enzyme-linked immunosorbent assay (ELISA). Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR) scale. Correlation analyses were performed to examine the relationship between tau oligomer levels, cognitive performance, and disease severity. Results: The mean tau oligomer level in AD patients was 120.5 ± 35.2 pg/mL. A significant negative correlation was observed between tau oligomer levels and MMSE scores (r = -0.65, p < 0.001), indicating that higher tau oligomer levels were associated with poorer cognitive performance. Furthermore, tau oligomer levels were positively correlated with CDR scores (r = 0.58, p < 0.001), suggesting a link between tau oligomers and disease severity. Conclusion: This study provides evidence for the involvement of tau oligomers in AD progression in the Indonesian population. Elevated CSF tau oligomer levels are associated with cognitive decline and disease severity in AD patients. These findings highlight the potential of tau oligomers as a therapeutic target and emphasize the need for further research to develop effective interventions.
Activated Growth Factors (AGF), an Advanced Platelet-Rich Plasma (PRP) Modality, as a Novel Biological Treatment for Partial Anterior Cruciate Ligament Tears: A Case Report Hidayat, Rachmat; Kemas Abdul Mutholib Luthfi; Olivia Azalia Putri; Sony Sanjaya; Linda Purnama; Sonya Syarifah; Nadia Khoirina; Abu Bakar; Rashidah Unaib Al Zayid; Reisha Notonegoro
Sriwijaya Journal of Surgery Vol. 8 No. 1 (2025): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v8i1.114

Abstract

Introduction: Partial anterior cruciate ligament (ACL) ruptures present a complex clinical challenge. Traditional treatment options, including conservative management and surgical reconstruction, often yield unpredictable outcomes and extended recovery periods. This case report explores the potential of activated growth factors (AGF), an advanced platelet-rich plasma (PRP) modality, as a novel biological treatment strategy for partial ACL tears. Case presentation: A 39-year-old male presented with right knee pain and instability following a twisting injury sustained during exercise. Magnetic resonance imaging (MRI) confirmed a partial tear of the anteromedial bundle of the ACL. The patient was treated with a series of three intra-articular injections of AGF, administered at weekly intervals. The AGF was prepared using a proprietary protocol aimed at optimizing growth factor concentration and release. The patient's progress was meticulously monitored through clinical evaluations and functional assessments at 3 and 6 months post-treatment. Conclusion: This case suggests that AGF may offer a promising alternative for the treatment of partial ACL tears, potentially facilitating accelerated healing and improved clinical outcomes. Further research, including controlled trials, is warranted to validate these findings and establish the efficacy and safety of AGF in a larger patient population.
Factors Influencing the Success Rates of In Vitro Fertilization (IVF) in Indonesian Couples: A Multicenter Study Sony Sanjaya; Wisnu Wardhana Putra; Theresia Putri Sinaga; Tanvir Ahmed
Sriwijaya Journal of Obstetrics and Gynecology Vol. 2 No. 1 (2024): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v1i2.85

Abstract

Introduction: In vitro fertilization (IVF) has become an increasingly important assisted reproductive technology for infertile couples in Indonesia. However, success rates remain variable. This multicenter study aimed to identify the factors influencing IVF success rates in Indonesian couples. Methods: A retrospective cohort study was conducted involving 1,245 couples who underwent IVF at three fertility centers in Indonesia between January 2019 and December 2022. Data were collected on demographic characteristics, infertility diagnoses, IVF protocols, and treatment outcomes. The primary outcome was live birth rate per embryo transfer. Multivariable logistic regression analysis was performed to identify independent predictors of IVF success. Results: The overall live birth rate per embryo transfer was 32.7%. Female age was a significant predictor of live birth, with success rates declining steadily after age 35. Other factors associated with higher success rates included the use of intracytoplasmic sperm injection (ICSI), blastocyst transfer, and a higher number of oocytes retrieved. Male factor infertility, endometriosis, and a history of previous failed IVF attempts were associated with lower success rates. Conclusion: This study identified several key factors influencing IVF success rates in Indonesian couples. Female age, ICSI utilization, blastocyst transfer, and oocyte yield were significant predictors of live birth. These findings can help clinicians counsel patients and optimize treatment strategies to improve IVF outcomes.
Forensic DNA Phenotyping for Predicting Externally Visible Characteristics in Indonesian Populations: A Novel Tool for Criminal Investigations Rinna Azrida; Febria Suryani; Bjorka Alma; Sony Sanjaya; Khairiel Anwar
Sriwijaya Journal of Forensic and Medicolegal Vol. 2 No. 2 (2024): Sriwijaya Journal of Forensic and Medicolegal
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjfm.v2i2.190

Abstract

Introduction: Forensic DNA phenotyping (FDP) is an emerging field that utilizes genetic information to predict an individual's externally visible characteristics (EVCs). While its application has shown promise in aiding criminal investigations globally, its utility within the diverse Indonesian population remains largely unexplored. This study aimed to investigate the potential of FDP for predicting EVCs in a representative sample of the Indonesian population, evaluating its accuracy and implications as a novel tool for criminal investigations in this unique context. Methods: This study involved the analysis of anonymized DNA samples from 1000 individuals self-identified as belonging to various ethnic groups across Indonesia. A panel of single nucleotide polymorphisms (SNPs) known to be associated with EVCs including hair color, eye color, skin pigmentation, and biogeographic ancestry (BGA) was selected based on existing literature. Genotyping data was generated to reflect the genetic diversity observed in Indonesian populations. Statistical analyses were performed to assess the predictive power of the SNP panel for each EVC and to evaluate the correlation between predicted phenotypes and self-reported characteristics. Results: The results demonstrated a moderate to high predictive accuracy for several EVCs within the Indonesian population. Skin pigmentation showed the highest predictability, followed by eye color and hair color. BGA prediction effectively clustered individuals based on their genetic profiles, aligning with the known population structure of Indonesia. Significant variations in allele frequencies for EVC-associated SNPs were observed across different ethnic groups, highlighting the importance of population-specific data. Conclusion: This study provides preliminary evidence suggesting that forensic DNA phenotyping holds significant potential as a novel tool for criminal investigations in Indonesia. The ability to predict EVCs from DNA could provide valuable leads in cases where traditional DNA profiling yields no matches. However, further research with real Indonesian population data is crucial to validate these findings and to develop robust, population-specific FDP models. Ethical and legal considerations surrounding the use of this technology in the Indonesian context must also be carefully addressed.
Preventing Cognitive Decline in Late-Life Depression: A Longitudinal Study on the Efficacy of Omega-3 Fatty Acid Supplementation in Older Adults in Palembang, Indonesia Sony Sanjaya; Febria Suryani; Pham Uyen; Maria Rodriguez; Muhammad Yoshandi
Scientia Psychiatrica Vol. 6 No. 4 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i2.190

Abstract

Introduction: Late-life depression (LLD) is a prevalent condition in older adults and a significant risk factor for cognitive decline and dementia. In Indonesia, with its aging population and specific dietary patterns, understanding interventions for LLD-associated cognitive impairment is crucial. Omega-3 polyunsaturated fatty acids (PUFAs) offer potential neuroprotective benefits. This study aimed to assess the efficacy of long-term omega-3 PUFA supplementation in mitigating cognitive decline among older adults with LLD in Palembang, Indonesia. Methods: This 24-month, randomized, double-blind, placebo-controlled trial was conducted in Palembang. Three hundred sixty older adults (aged ≥60 years) with a current DSM-5 diagnosis of Major Depressive Disorder (MDD) and subjective cognitive complaints were randomized (1:1) to receive either daily oral supplementation of 2.2 grams of omega-3 PUFAs (containing 1320 mg eicosapentaenoic acid [EPA] and 880 mg docosahexaenoic acid [DHA]) or a matched placebo (corn oil). The primary outcome was the change in the Indonesian version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog-INA) score over 24 months. Secondary outcomes included changes in the Montreal Cognitive Assessment-Indonesian version (MoCA-INA), Geriatric Depression Scale (GDS-30), Instrumental Activities of Daily Living (IADL), serum Brain-Derived Neurotrophic Factor (BDNF), and high-sensitivity C-Reactive Protein (hs-CRP). Results: Over 24 months, the omega-3 group exhibited significantly less decline on the ADAS-Cog-INA compared to the placebo group (mean difference: -2.1 points; 95% CI: -3.8 to -0.4; p=0.018). Statistically significant benefits for the omega-3 group were also observed in MoCA-INA scores (mean difference: 1.5 points; p=0.025) and GDS-30 scores (mean difference: -2.5 points; p=0.011). BDNF levels increased significantly in the omega-3 group relative to placebo (p=0.008), while hs-CRP levels showed a non-significant trend towards reduction (p=0.072). Conclusion: Long-term supplementation with 2.2 g/day of EPA-rich omega-3 PUFAs resulted in a modest but statistically significant attenuation of cognitive decline and improvement in depressive symptoms in older adults with LLD in Palembang. These findings suggest that omega-3 PUFAs could be a valuable adjunctive therapeutic strategy in this specific Southeast Asian population.
CRISPRi-Mediated Repression of gtfB Attenuates Streptococcus mutans Virulence and Promotes Ecological Homeostasis in a Preclinical Cariogenic Biofilm Model Khairiel Anwar; Maria Rodriguez; Sony Sanjaya; Danniel Hilman Maulana; Karina Chandra; Isadora Selestine
Crown: Journal of Dentistry and Health Research Vol. 3 No. 1 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i1.234

Abstract

Introduction: Streptococcus mutans is a primary etiological agent of dental caries, largely due to its capacity to form robust, acidogenic biofilms. This virulence is critically dependent on glucosyltransferases, particularly GtfB, which synthesizes the adhesive extracellular glucan matrix. Conventional antimicrobial strategies often lack specificity, leading to oral dysbiosis. This study aimed to develop and evaluate a highly targeted CRISPR interference (CRISPRi) system to silence the gtfB gene in S. mutans, thereby inhibiting its cariogenic potential without adversely affecting the viability of key oral commensal species. Methods: A CRISPRi system, comprising a nuclease-deactivated Cas9 (dCas9) and a single guide RNA (sgRNA) targeting the gtfB promoter, was engineered into S. mutans UA159. The efficacy of gtfB silencing was quantified via qRT-PCR. The consequential effects on bacterial growth kinetics, insoluble glucan synthesis, and single-species biofilm formation were assessed using spectrophotometry, anthrone assays, crystal violet staining, and confocal laser scanning microscopy (CLSM). The ecological impact was investigated in a multi-species biofilm model containing S. mutans and the commensal bacteria Streptococcus gordonii, Streptococcus oralis, and Actinomyces naeslundii, with microbial composition analyzed by species-specific qPCR. All research activities were conducted in Indonesia. Results: The CRISPRi system induced a profound and specific downregulation of gtfB mRNA expression by over 98% (p<0.001) in the engineered S. mutans strain compared to the wild-type. This silencing did not impair bacterial planktonic growth. However, it led to a significant reduction in insoluble glucan production by 85% (p<0.001) and a corresponding 79% decrease in total biofilm biomass (p<0.001). CLSM imaging confirmed the formation of structurally deficient biofilms with minimal extracellular matrix. In the multi-species model, repression of S. mutans virulence significantly altered the biofilm ecology, resulting in a 65% reduction in the proportional abundance of S. mutans and a concomitant increase in the representation of commensal species, thereby fostering a community structure more aligned with oral health. Conclusion: Targeted repression of the gtfB gene using a CRISPRi-based approach effectively 'disarms' S. mutans, neutralizing its primary cariogenic mechanism without being bactericidal. This strategy not only attenuates its virulence but also shifts the ecological balance in favor of beneficial commensal bacteria. These findings underscore the therapeutic potential of gene-targeted virulence modulation as a precise, ecologically-sound strategy for the prevention and treatment of dental caries.
Co-Authors Abu Bakar Agnes Mariska Bjorka Alma Brenda Jaleel Cindy Susanti Danniel Hilman Maulana Febria Suryani Husin Sastranagara Isadora Selestine Karina Chandra Kemas Abdul Mutholib Luthfi Khairiel Anwar Linda Purnama Maria Rodriguez Muhammad Yoshandi Nadia Khoirina Olivia Azalia Putri Pham Uyen RACHMAT HIDAYAT Rashidah Unaib Al Zayid Reisha Notonegoro Rinna Azrida Sonya Syarifah Tanvir Ahmed Theresia Putri Sinaga Wisnu Wardhana Putra Yi-Fen Huang