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All Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Global Health research Narra J
Lubis, Muara P.
Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Predictive biomarkers of preeclampsia severity in a low resource setting: Role of red blood cell indices, NLR, and albumin-to-creatinine ratio Tobing, Immanuel DL.; Lumbanraja, Sarma N.; Lintang, Letta S.; Edwar, Rafli R.; Adenin, Ichwanul; Lubis, Muara P.; Sukatendel, Khairani; Suarthana, Eva
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.729

Abstract

Preeclampsia (PE), a serious medical condition with substantial maternal and perinatal implications, poses a significant challenge, particularly in high-incidence countries like Indonesia. Red blood cell (RBC) indices, neutrophil-to-lymphocyte ratio (NLR), and microalbuminuria (albumin-to-creatinine ratio (ACR)) may signal systemic inflammation and endothelial dysfunction, recently recognized as potential indicators for diagnosing and predicting disease severity. The aim of this study was to analyze RBC indices, NLR, and ACR changes in women with PE and their potential for predicting disease severity. A cross-sectional study was conducted at multi-center hospitals across Medan, Indonesia, from June 2022 to June 2023. The patients were grouped into PE cases with and without severe features. Demographic characteristics and complications were recorded while blood and urine were tested. The Chi-squared test, Fisher's exact test and Mann-Whitney test were used to determine biomarkers associated with severe PE. A total of 208 PE patients were included in the study (104 patients for each PE with and without severe features). Our data indicated that PE patients with severe features had higher red cell distribution width (18.5% vs 13.7%; p<0.001), NLR (5.66% vs 4.1%; p<0.001), and ACR (755.97 mg/dL vs 468.63 mg/dL; p<0.001) compared to those without severe features. In contrast, the platelet count was lower in severe features than those without (21.9 × 106/µL vs 27.0 × 106/µL; p=0.002). This study highlighted that PE patients with severe features predominantly had higher levels of RDW, NLR, and ACR and lower platelet counts compared to those without severe features. Therefore, basic tests such as complete blood count and urinalysis, which are inexpensive and feasible in primary care settings with limited resources, offer hope as valuable diagnostic biomarkers for pregnant women diagnosed with PE in a low resource setting.
Correlation between LDH, Liver Function, Platelets and Proteinuria in Preeclampsia with Severe Features Shifa, Rifhani Ashilla; Lubis, Muara Panusunan; Lubis, Hilma Putri; Barus, Melvin Nova Gunawanto
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.635

Abstract

Objectives: To identify the relationship between LDH, bilirubin, SGPT, SGOT, and platelets with proteinuria in preeclampsia with severe features patients. Method: This study is an observational analytical with a retrospective cross-sectional design. The samplings contain 70 patients from the medical records of patients who were diagnosed with preeclampsia with severe features at H. Adam Malik Hospital Medan from January 2020 to March 2023.Results: It was found that 74.3% of the population had semiquantitative urine protein levels ≥+2. The average levels of LDH, total bilirubin, SGPT, SGOT, and platelets were 514.64 U/L, 0.9 mg/dL, 57.77 U/L, 64.01 U/L, and 197,585/mm3, respectively. Statistical analysis showed a positive association between proteinuria and LDH (p=0.001). However, there was no meaningful association between liver and platelet function and proteinuria.Conclusion: There is a relationship between LDH and proteinuria in severe preeclampsia patients.Hubungan antara LDH, Fungsi Hati, Trombosit dengan Proteinuria pada Pasien Preeklamsia BeratAbstrakTujuan: Untuk mengidentifikasi hubungan antara LDH, bilirubin, SGPT, SGOT, dan trombosit dengan proteinuria pada pasien preeklampsia dengan gejala berat.Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain potong lintang retrospektif. Sampel terdiri dari 70 pasien dari rekam medis pasien yang didiagnosis dengan preeklampsia berat di RSUP H. Adam Malik Medan pada periode Januari 2020 hingga Maret 2023.Hasil: Ditemukan bahwa 74,3% dari populasi memiliki kadar protein urin semikuantitatif ≥+2. Kadar rata-rata LDH, bilirubin total, SGPT, SGOT, dan trombosit masing-masing adalah 514,64 U/L, 0,9 mg/dL, 57,77 U/L, 64,01 U/L, dan 197.585/mm3. Analisis statistik menunjukkan hubungan positif antara proteinuria dan LDH (p=0,001). Namun, tidak ada hubungan yang bermakna antara fungsi hati dan trombosit dengan proteinuria.Kesimpulan: Terdapat hubungan antara LDH dan proteinuria pada pasien preeklampsia berat.Kata kunci: hemolisis, fungsi hati, trombosit, preeklamsia berat, proteinuria
Cervical Cancer Patient Experiences with Chemotherapy in Conducting Their Role as Wives Rambe, Jamila; Nasution, Siti Saidah; Lubis, Muara Panusunan
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.5093

Abstract

Wives who suffer from cervical cancers and receive chemotherapy treatment potentially have the potential to experience a decrease in the reproductive function of the organs so that the role as a wife experiences changes such as impaired gynecological functions which result in nonfulfillment of sexual desires, pain during intercourse, bleeding, emotional disturbances, and fatigue so that the daily activities of cervical cancer sufferers experience a significant decrease. Objective to understand cervical cancer patients' experiences with chemotherapy in conducting their role as wives. the study was a qualitative design with a phenomenological approach. Data were collected using an interview with 8 participants and analyzed using colaizzi. Then, it is transcribed and analyzed repeatedly. The second step, analyzing, is conducted by extracting significant statements, categorizing, and understanding the essential meaning. In the third step, describing, the researcher communicates, concludes, and defines the phenomenon. 6 Themes are found in this research: 1) conducting the role as a wife part, 2) sexual relationship disorders, 3) self –concept disorder 4) anxiety of cancer 5) medication side effects, 6) getting the family support. The study result indicates that despite the side effects of chemotherapy experienced by wives who suffer from cervical cancer, they still can conduct their role as wives supported by the family.
Co-Authors Adenin, Ichwanul Barus, Melvin Nova Gunawanto Edwar, Rafli R. Eva Suarthana Hilma Putri Lubis Lintang, Letta S. Lumbanraja, Sarma N. Nasution, Siti Saidah Rambe, Jamila Shifa, Rifhani Ashilla Sukatendel, Khairani Tobing, Immanuel DL.