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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Paediatrica Indonesiana Indonesian Journal of Global Health research Cermin Dunia Kedokteran MEDICINUS Cermin Dunia Kedokteran
OLGA RASIYANTI SIREGAR, OLGA RASIYANTI
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Sumatera Utara/RSUP. H. Adam Malik, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Mature Teratoma Intrapulmonary in Adolescent SIREGAR, OLGA RASIYANTI; LESTARI, WAHYUNINGSIH; ROSDIANA, NELLY
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Mature teratoma is the most common primary germ cell tumor in the mediastinum, but very rare in the lung. A very rare case of mature giant intrapulmonary teratoma in a 14 year old female is reported. She had chronic cough, recurrent fever, chest pain, weight loss and history of breathless for six months. A chest x-ray showed a large mass with atelectasis of the left lung and thoracic CT scan revealed a giant neoplasm of the left lung, sized about 13x19 cm with calcification. The patient underwent left thoracotomy posterolateral, the tumor was totally resected with pneumonectomy. The histopatological examination revealed a mature teratoma. Intrapulmonary teratoma is very rare tumors with nonspecific signs and symptoms. Total removal tumor is the treatment of choice for this type of teratoma.
Menilai Status Nutrisi Pasien Leukemia Limfoblastik Akut (LLA) Anak Lubis, Irania Thariaty; Lubis, Bidasari; Sembiring, Tiangsa; Rosdiana, Nelly; Nafianti, Selvi; Siregar, Olga Rasiyanti
Cermin Dunia Kedokteran Vol 47, No 2 (2020): Penyakit Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (690.932 KB) | DOI: 10.55175/cdk.v47i2.359

Abstract

Leukemia adalah keganasan yang paling sering pada anak. Status nutrisi pada kasus leukemia anak akan lebih baik dinilai menggunakan antropometri lengan, seperti area otot lengan tengah. Leukemia is the most common malignancy in children. Nutritional status of children with leukemia is best measured with anthropometric arm like mid-arm muscle area.
Status Imunitas pada Anak dengan Anemia Defisiensi Besi Sembiring, Krisnarta; Lubis, Bidasari; Rosdiana, Nelly; Nafianti, Selvi; Siregar, Olga Rasiyanti
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.82 KB) | DOI: 10.55175/cdk.v45i9.608

Abstract

Anemia defisiensi besi merupakan penyakit akibat defisiensi nutrisi terbanyak di dunia. Anak dengan anemia defisiensi besi mengalami gangguan imunitas yang bervariasi, mencakup nonspesifik, seluler, dan humoral. Hal ini meningkatkan kerentanan terhadap infeksi pada populasi tersebut. Anemia defisiensi besi yang diperberat oleh infeksi akan menimbulkan dampak negatif yang lebih besar terhadap kondisi kesehatan anak.Iron deficiency anemia is the most frequent disease caused by nutritional deficiency worldwide. Children with iron deficiency anemia suffer from various immunity impairments, including nonspecific, cellular, and humoral immunity; increasing their vulnerability to infection. Iron deficiency anemia along with infection will aggravate negative impacts toward children’s health status.
Renal Function in Children with β-Thalassemia Major Treated with Iron Chelating Agent Olga Rasiyanti Siregar; Rosmayanti Syafriani Siregar; Bidasari Lubis
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1053

Abstract

BACKGROUND: Thalassemia is a disorder of inherited blood and inticated by the abnormal hemoglobin. Transfusion and iron chelation are part of thalassemia management. Iron chelating agent reduces complications due to the excess iron as a result of repeated transfusions, hence, increasing the survival rate. However, prolonged intake of iron chelating agent may increase the risk of renal function impairment. To date, evaluation of renal function in children with β-thalassemia in Medan has never been reported. The objective of this study was to evaluate renal function and other factors in children with β-thalassemia.METHODS: Fourty-five children with β-thalassemia was recruited in this study. Renal function, represented by estimated glomerular filtration rate (eGFR)and serum ferritin levels were examined. The measurement of eGFR was using Schwartz method.RESULTS: Decreased eGFR observed in some the children (2 patients) with β-thalassemia major treated with iron chelating agent. None of the factors examined had association with serum creatinine level. Children's age and duration of iron chelating agent intake had positive correlation with their eGFR (r=0.506, p<0.001 and r=0.518, p<0.001, respectively). However, serum ferritin levels was not a predictor for renal function impairment.CONCLUSION: Most of children with β-thalassemia major treated with iron chelating agent have normal renal function, nevertheless, decreased renal function is observed in few children. Highlighted, renal function examinations should be performed routinely as iron chelating agent administration is a long-term therapy in children with β-thalassemia major.KEYWORDS: β-thalassemia major, renal function, serum ferritin levels, iron chelating agent
Prevalence and risk factors of hearing loss in children with solid tumors treated with platinum-based chemotherapy Eka D Edward; Nelly Rosdiana; Farhat Farhat; Olga Rasiyanti Siregar; Bidasari Lubis
Paediatrica Indonesiana Vol 55 No 3 (2015): May 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.793 KB) | DOI: 10.14238/pi55.3.2015.121-5

Abstract

Background The platinum-based chemotherapy drugs, cisplatin and carboplatin, are widely used in the treatment of several types of solid tumors. However, the treatment has side effects including hearing loss.Objective To evaluate the prevalence of hearing loss related to platinum-based chemotherapy and to identify associated factors.Methods A cross-sectional study was performed in Adam Malik Hospital, Medan, North Sumatera, from April to July 2012. Twenty-two subjects who fulfilled the eligibility criteria underwent otoacoustic emission evaluations. Eleven children had received cisplatin and eleven had received carboplatin. The association between hearing loss and risk factors was assessed using Fisher’s exact and Chi-square tests.Results Seven subjects with hearing loss were identified. Five of these patients (5 out of 11) had received cisplatin and 2 patients (2 out of 11) had received carboplatin. There was no statistically significant difference between carboplatin- and cisplatin-associated hearing loss (P=0.361). Neither gender (P=0.452) nor age (P=0.212) was related to hearing loss. However, higher cumulative chemotherapy doses (cisplatin >600 mg/m² and carboplatin >1800 mg/m²) were associated with hearing loss (P=0.022 and P=0.004, respectively).Conclusion Patients who had higher cumulative doses of platinum-based chemotherapy are at risk for developing hearing loss.
Quality of life in children with cancer and their normal siblings Hilda Hilda; Bidasari Lubis; Hakimi Hakimi; Olga Rasiyanti Siregar
Paediatrica Indonesiana Vol 55 No 5 (2015): September 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.585 KB) | DOI: 10.14238/pi55.5.2015.243-7

Abstract

Background Cancer treatment in children influences the quality of life of patients and their families. The Pediatric Quality of Life (PedsQL) inventory is a questionnaire to assess quality of life of the healthy and ill children. Objective To compare quality of life in children with cancer and their normal siblings, and to compare quality of life in those with hematologic malignancies to those with solid tumors. Methods A cross-sectional study was conducted among 5-to-18- year-olds at the Hematology-Oncology Division at Haji Adam Malik Hospital, Medan, North Sumatera, from May to July 2012. The case group (subjects with cancer) filled the PedsQL 3.0 and 4.0 questionnaires, while the control group (normal siblings) filled only the PedsQL 4.0 questionnaire. Independent T-test was used to compare the quality of life between children with cancer and their normal siblings. Results There were 46 children in each group. The PedsQL 4.0 results in children with cancer and their normal siblings, and PedsQL 3.0 between hematology malignant and solid cancer were as follows: physical function 36.9 vs. 80.7, respectively (95%CI of differences -52.639 to -34.990; P= 0.0001), emotional function 40.4 vs. 69.3, respectively (95%CI of differences -35.912 to -21.914; P=0.0001), social function 71.5 vs. 93.9, respectively (95%CI of differences - 29.238 to -15.587; P=0.0001), school function 20.7 vs. 74.2, respectively (95%CI of differences - 62.124 to -44.832; P=0.0001), and total score 42.1 vs. 79.3, respectively (95%CI of differences - 43.066 to -31.344; P=0.0001). School function was the most affected parameter in children with cancer compared to their normal siblings. Conclusion There is a significant difference in quality of life between children with cancer and their normal siblings, for all four parameters examined by the PedsQL inventory. However, there are no significant differences in quality of life between children with hematologic malignancy and those with solid cancer.
Delayed cord clamping for prevention of iron deficiency anemia in term infants Olga Rasiyanti Siregar; Bugis Lubis; Muara Lubis; Bidasari Lubis; Guslihan Dasa Tjipta
Paediatrica Indonesiana Vol 52 No 4 (2012): July 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.655 KB) | DOI: 10.14238/pi52.4.2012.223-8

Abstract

Background Iron deficiency childhood is a concern due to its potentially detrimental effectson development, some of which may be irreversible even after irontreatment. Delayed cord clamping may prevent IDA by increasingan infant's iron reserve at birth.Objective We aimed to evaluate the effect of delayed umbilicalcord clamping at birth on the iron status in newborns at age 24hours of life.Methods This randomized, single􀁒blind study was conducted fromMarch to May 2009, at two general hospitals in Medan, NorthSumatera Province. Eligible newborn infants were randomlyassigned to one of two groups: early cord clamping (Eee)performed 15 seconds after delivery or delayed cord clamping(DeC) performed 2 minutes after delivery. Infants were placed ontheir mothers' abdomens before the umbilical cords were clamped.Hematologic status was determined from umbilical cord blood.Results Sixty􀁒three subjects were included in our study, consistingof31 infants in the Eee group and 32 infants in the Dec group.We found that mean neonatal hemoglobin level was higher inthe Dec group than in the Eee group ( 18.4 g% and 16.2 g%,respectively, P=O.OOOl). Also, mean ferritin level was higher inthe Dec group than in the Eee group (556 mg/dL and 329 mg/dL, respectively, p=o.o 15). Other hematological status indicators,including mean hematocrit and mean corpuscular volume (MeV)level, were also higher in the Dec group. However, mean redblood cell levels were not significantly groups. Nor was there a significant level between the Dec and Eee groups.Concl usion Dela y ed cord c l a m p i n g m a y improve ironstatus and prevent IDA in term infants. [Paediatr Indones.2012;52:223-8].
Menilai Status Nutrisi Pasien Leukemia Limfoblastik Akut (LLA) Anak Irania Thariaty Lubis; Bidasari Lubis; Tiangsa Sembiring; Nelly Rosdiana; Selvi Nafianti; Olga Rasiyanti Siregar
Cermin Dunia Kedokteran Vol 47, No 2 (2020): Penyakit Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i2.359

Abstract

Leukemia adalah keganasan yang paling sering pada anak. Status nutrisi pada kasus leukemia anak akan lebih baik dinilai menggunakan antropometri lengan, seperti area otot lengan tengah. Leukemia is the most common malignancy in children. Nutritional status of children with leukemia is best measured with anthropometric arm like mid-arm muscle area.
Status Imunitas pada Anak dengan Anemia Defisiensi Besi Krisnarta Sembiring; Bidasari Lubis; Nelly Rosdiana; Selvi Nafianti; Olga Rasiyanti Siregar
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i9.608

Abstract

Anemia defisiensi besi merupakan penyakit akibat defisiensi nutrisi terbanyak di dunia. Anak dengan anemia defisiensi besi mengalami gangguan imunitas yang bervariasi, mencakup nonspesifik, seluler, dan humoral. Hal ini meningkatkan kerentanan terhadap infeksi pada populasi tersebut. Anemia defisiensi besi yang diperberat oleh infeksi akan menimbulkan dampak negatif yang lebih besar terhadap kondisi kesehatan anak.Iron deficiency anemia is the most frequent disease caused by nutritional deficiency worldwide. Children with iron deficiency anemia suffer from various immunity impairments, including nonspecific, cellular, and humoral immunity; increasing their vulnerability to infection. Iron deficiency anemia along with infection will aggravate negative impacts toward children’s health status.
Perawatan Mulut untuk Pencegahan Mukositis Oral pada Penderita Kanker Anak yang Mendapat Kemoterapi Christina Hasibuan; Bidasari Lubis; Nelly Rosdiana; Selvi Nafianti; Olga Rasiyanti Siregar
Cermin Dunia Kedokteran Vol 46, No 6 (2019): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i6.467

Abstract

Mukositis oral merupakan peradangan mukosa rongga mulut yang sering ditemukan pada pasien yang mendapat kemoterapi antikanker. Angka kejadian mukositis oral pada populasi anak dan remaja 40-50%. Mukositis oral dapat berdampak negatif antara lain penurunan kualitas hidup, pengurangan dosis terapi antikanker dan peningkatan biaya perawatan. Perawatan mulut meliputi evaluasi berkala kondisi mulut, edukasi pasien dan/atau keluarga, penyikatan gigi, flossing dan berkumur sangat disarankan untuk mengurangi angka kejadian mukositis oral.Oral mucositis is an inflamation of the oral cavity mucosa; it is the most common complication of cancer chemotherapy. The incidence rate of oral mucositis is 30-80% and in pediatric population is 40-50%. Oral mucositis can cause negative impacts on quality of life, treatment planning, and cost ; also on morbidity and mortality. Basic principles of oral health care consist of periodical oral heatlh evaluation, educating patient and/or parents, brushing, flossing, and mouth rinse.
Co-Authors Bidasari Lubis Bidasari Lubis Bidasari Lubis Bidasari Lubis Bidasari Lubis Bidasari Lubis Bugis Lubis Christina Hasibuan Effendi, Kevin Eka D Edward Farhat Farhat Guslihan Dasa Tjipta Hakimi Hakimi Hendri Wijaya, Hendri Hilda Hilda Irania Thariaty Lubis Krisnarta Sembiring Lubis, Irania Thariaty Malisie, Ririe Fachrina Muara Lubis Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Nelly Rosdiana Pasaribu, Ayodhia Pitaloka Riano, Dwika Intania Rini Savitri Daulay, Rini Savitri Rosmayanti Syafriani Siregar Selvi Nafianti Selvi Nafianti Selvi Nafianti Selvi Nafianti Selvi Nafianti Selvi Nafianti, Selvi Sembiring, Krisnarta Siregar, Rosmayanti Syafriani Siska Natalia Situmeang Tanjung, Ika Citra Dewi Tiangsa Sembiring Tiangsa Sembiring, Tiangsa Wahyuni, Arlinda Sari WAHYUNINGSIH LESTARI, WAHYUNINGSIH