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Diagnosis and treatment of leprous neuropathy: a review Thiodorus, Fira; Thiodorus, Robert; Sadeli, Marrietta Sugiarti
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 7, Issue 1 (January 2024)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v7i1.78

Abstract

One significant subset of curable neuropathies brought on by Mycobacterium leprae is leprous neuropathy. Millions of people in most underdeveloped nations suffer from leprous neuropathy, which can lead to debilitating motor deficiencies, sensory loss, and skin deterioration. The peripheral nerve system and skin are the primary organs affected by leprosy. The clinical characteristics, cutaneous histology, and bacteriology may all be used to conclude the diagnosis. Leprosy neuropathy diagnosis also requires a nerve biopsy. Needles electromyography and nerve conduction investigations are two examples of electrophysiologic nerve examinations. Both studies offer details on the degree of nerve involvement, the location of lesions, and the underlying mechanism of injury. For patients with leprosy neuropathy, multiple medication therapies are recommended. Aside from standard medical care, acute neuropathy may sometimes require surgical intervention. In reversal reactions, corticosteroids can prevent or lessen nerve damage.
Stroke Iskemik pada Pasien Hemodialisis : Laporan Kasus Thiodorus, Fira; Mayung, Claraiva; Yuliani, Desie
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.119-126

Abstract

Stroke and chronic kidney disease are major health problems worldwide. Acute ischemic stroke is a significant complication in patients with end-stage renal disease undergoing hemodialysis. The incidence of stroke is about 8-10 times higher in chronic renal failure patients on hemodialysis compared to the general population. The annual incidence rate of acute ischemic stroke is reported to be about 4% in chronic renal failure patients on hemodialysis. Initiation of dialysis in chronic renal failure patients is associated with an increased risk of stroke. Chronic renal failure disease is an independent risk factor for stroke. A 57-year-old woman complained of left-side weakness during hemodialysis. Paresis of cranial nerve VII and XII and grade 3 flaccid hemiparesis sinistra were found. Electrocardiogram showed normal atrial fibrillation response. Non-contrast head CT scan showed subacute ischemic cerebral infarction in the right internal capsule. Factors that cause stroke in chronic renal failure are endothelial dysfunction, accelerated arteriosclerosis, and impaired cerebral autoregulation.