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All Journal E-Jurnal Medika Udayana Jurnal Biomedika dan Kesehatan Bali Dermatology and Venereology Journal Indonesian Journal of Global Health research Bali Dermatology Venereology and Aesthetic Journal
Sadeli, Marrietta Sugiarti
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Dermoscopy in superficial fungal infection Sawitri, Putu Dyah; Karmila, I Gusti Ayu Agung Dwi; Sadeli, Marrietta Sugiarti
Bali Dermatology and Venereology Journal Vol 4, No 2 (2021)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v4i2.52

Abstract

 Superficial fungal infections are one of the most common skin infection infections. It is caused by fungal pathogens and are limited to the outer layer of the skin, hair, and nails. Superficial fungal infections include dermatophytosis, superficial candidiasis, and diseases caused by Malassezia spp. Most physicians diagnose and treat superficial fungal infections based solely on clinical appearance. But unfortunately, there are many other infectious and non-infectious diseases that have similar clinical appearance.Dermoscopy is a practical and noninvasive imaging method that allows magnifying clinical surface images that are normally invisible under a magnifying lens. In diagnosing superficial mycosis, dermoscopy was found to have a higher sensitivity and specifity compared to pottasium chloride (KOH) and fungal culture.More understanding is needed about the use of dermoscopy in diagnosing superficial fungal infections in the hope of being able to provide an overview of superficial fungal infections and dermoscopy, as well as dermoscopy features in some superficial fungal infections. In this article, the author describe dermoscopic findings in various superficial fungal infections on the skin, hair, and nails.
VALIDASI KRITERIA MINOR PADA DERMATITIS ATOPIK Sadeli, Marrietta Sugiarti; Wardhana, Made
E-Jurnal Medika Udayana Vol 11 No 2 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i02.P01

Abstract

Dermatitis atopik adalah penyakit kulit inflamatif kronis, disebut juga eksema atopik, prurigo besnier, neurodermatitis diseminata. Diagnosis dermatitis atopik berdasarkan keluhan dan gambaran klinis. Hanifin Rajka telah membuat kriteria diagnosis untuk dermatitis atopik yang didasarkan pada kriteria mayor dan minor yang sampai sekarang masih banyak digunakan. Kriteria mayor dan beberapa kriteria minor pada setiap pusat pelayanan berbeda-beda. Tujuan penelitian ini adalah untuk mencari frekuensi, sensitivitas dan spesifisitas kriteria minor dan nilai pH. Ini merupakan sebuah studi case-control untuk mengetahui frekuensi, sensitivitas dan spesifisitas kriteria minor dan nilai pH pada pasien dermatitis atopik di RSUP Sanglah, Denpasar. Terdapat 29 kasus dan 24 kontrol, dihitung sensitivitas, spesifisitas, nilai prediktif positif dan nilai prediktif negatif pada masing-masing kriteria minor. Xerosis memiliki nilai sensitivitas yang paling tinggi, sebesar 89,6 %. Dari 23 kriteria minor, beberapa diantaranya diteliti pada studi ini. Tanda yang paling sering dijumpai adalah xerosis/kulit kering terjadi pada 26 kasus diikuti kecendungan infeksi kulit berulang terjadi pada 25 kasus dan awitan dini pada 24 kasus. Dengan hasil validasi, sensitivitas tertinggi pada Xerosis sebesar 89.6%, spesifisitas dan PPV tertinggi pada Dennie-Morgan infraorbital sebesar masing-masing 91,6% dan 90% dan NPV tertinggi pada tanda Xerosis sebesar 84,2%. Temuan lain berupa hasil pengukuran nilai pH terbanyak pada nilai pH tinggi (>5,5) sebesar 23 kasus dengan sensitivitas sebesar 79,3%. Kata kunci: validasi, kriteria diagnosis, kriteria minor, kriteria mayor, dermatitis atopik, eksema atopik
Diagnosis and treatment of leprous neuropathy: a review Thiodorus, Fira; Thiodorus, Robert; Sadeli, Marrietta Sugiarti
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 7, Issue 1 (January 2024)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v7i1.78

Abstract

One significant subset of curable neuropathies brought on by Mycobacterium leprae is leprous neuropathy. Millions of people in most underdeveloped nations suffer from leprous neuropathy, which can lead to debilitating motor deficiencies, sensory loss, and skin deterioration. The peripheral nerve system and skin are the primary organs affected by leprosy. The clinical characteristics, cutaneous histology, and bacteriology may all be used to conclude the diagnosis. Leprosy neuropathy diagnosis also requires a nerve biopsy. Needles electromyography and nerve conduction investigations are two examples of electrophysiologic nerve examinations. Both studies offer details on the degree of nerve involvement, the location of lesions, and the underlying mechanism of injury. For patients with leprosy neuropathy, multiple medication therapies are recommended. Aside from standard medical care, acute neuropathy may sometimes require surgical intervention. In reversal reactions, corticosteroids can prevent or lessen nerve damage.
Pencegahan Disabilitas pada Kusta Thiodorus, Robert; Rusyati, Luh Made Mas; Sadeli, Marrietta Sugiarti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.216-223

Abstract

Leprosy, a chronic granulomatous infectious disease caused by Mycobacterium Leprae, presents a complex challenge with profound social, physical, and economic implications. The burden of leprosy is a persistent concern in many developing countries, despite substantial control efforts. The World Health Organization (WHO) initiated the "Global Leprosy Strategy 2016-2020" to combat this issue, focusing on reducing children diagnosed with leprosy, eliminating visible deformities, and enacting anti-discrimination laws. Disability in leprosy is multifaceted and preventing disability in leprosy is a critical endeavor, such as prophylaxis, early diagnosis, and comprehensive care strategies. Vaccination with the BCG vaccine provides moderate protection, and combining it with single-dose rifampicin (SDR) can enhance its effectiveness, particularly for lepromatous cases with delayed diagnoses. Improved training for healthcare providers can facilitate early detection, reducing the risk of disability. After effective leprosy treatment, longterm morbidity remains a concern. Continued education of healthcare workers and communities is pivotal in preventing damage to hands, feet, and eyes, especially in cases of peripheral neuropathy. Disability progression is a substantial risk, highlighting the need for ongoing medical assessments, even post-MDT treatment. Restructuring primary care services to ensure quality post-treatment care is essential. Stigma remains a significant obstacle in leprosy prevention. Community awareness and stigma reduction can motivate individuals to seek treatment. Epidemiological patterns transmission within households, play a crucial role in identifying new cases. Routine examinations of household contacts of leprosy patients can expedite early diagnosis. Nutrition also plays a role in leprosy prevention. Ensuring access to nutritious food is critical to reducing the risk of developing the disease. In conclusion, the prevention of disability in leprosy is a multifaceted endeavor that demands comprehensive strategies, early intervention, awareness, and community engagement. Addressing this issue is vital for improving the quality of life for individuals affected by leprosy and for achieving a leprosy-free world.
Rambut Beruban Prematur pada Anak Usia Tujuh Tahun Wijaya, Edward; Winaya, Ketut Kwartantaya; Sadeli, Marrietta Sugiarti
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.345-350

Abstract

Premature graying of hair is defined as the occurrence of gray hair, depending on ethnicity, before the age of 30 in Africans, 25 in Asians, and 20 in Caucasians. Premature graying is an important cause of low self-esteem, which often interferes with sociocultural adjustment. Premature graying, known as premature canitis, the exact etiopathogenesis is still unknown, although it has been associated with disorders of premature aging, atopy, and autoimmune diseases. Many pathological conditions have been discussed in relation to premature canitis such as certain medications, deficiencies of Vitamin B12, vitiligo, hypothyroidism, and progeroid syndromes. Premature canitis may occur as an autosomal dominant condition only or associated with premature aging syndromes or various autoimmune. This condition needs to be differentiated from the various genetic hypomelanosis hair disorders. Patients with PGH should be evaluated for metabolic diseases and syndromes. Among the various pharmacotherapeutic management options, calcium pantothenate, PABA, and a combination of calcium pantothenate + PABA can be given. Some herbal agents such as Anu-tailam has been evaluated in a clinical research setting. Hair dye remains the primary treatment modality for cosmetic problems after nutritional supplementation. Lastly, addressing underlying pathological conditions often results in a reversal of the condition in many cases.
the Correlation Between Erythrocyte Index Levels with The Anemia Morphology in Leprosy Patients Before Therapy: A Secondary Data Research Sadeli, Marrietta Sugiarti; Rusyati, Luh Made Mas; Karna, Ni Luh Putu Ratih Vibriyanti
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5826

Abstract

Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae. Chronic infection can cause anemia of chronic disease which is characterized by normochromic normocytic morphology. This study was conducted to assess the relationship between erythrocyte index levels (MCV, MCH, and MCHC) with the morphology of anemia that occurs in leprosy patients before treatment. A cross-sectional study using secondary data from medical records and management information system applications at Sanglah Hospital. The variables of this study were age, sex, hemoglobin levels, and erythrocyte index levels (MCV, MCH, and MCHC). Data were collected after permission was granted and ethical clearance was completed. Of the 156 study samples, 106 patients were diagnosed with leprosy who had not received therapy and 50 patients were not leprosy. The mean age of the patients was 39.15 ± 12.218 years and male patients were more common than female patients. There was a positive correlation between anemia, normal erythrocyte index levels, and the leprosy group. Following are the p-values, prevalence ratios, and confidence intervals; anemia [p= 0.017; PR(95% CI)= 1,458(1.034-2.056)], MCV, MCH, and MCHC [p= 0.020; PR(95% CI)= 1,268(1.010-1.591); p= 0.015; PR(95% CI)= 1,293(1,021-1,639); p= 0.009; PR(95% CI)= 1,297(1,036-1,624)]. The results of the analysis were statistically significant and clinically important. Leprosy patients had anemia before therapy with normochromic normocytic anemia morphology in accordance with anemia of chronic disease.
Co-Authors Edward Wijaya, Edward I Gusti Ayu Agung Dwi Karmila Luh Made Mas Rusyati Made Wardhana Ni Luh Putu Ratih Vibriyanti Karna Sawitri, Putu Dyah Thiodorus, Fira Thiodorus, Robert Winaya, Ketut Kwartantaya