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All Journal Jurnal Neuroanestesi Indonesia Majalah Anestesia & Critical Care (MACC)
Nasution, Putra Fajar
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Biochemistry, Genetics & Molecular Biology Education Medicine & Pharmacology Neuroscience Public Health

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Correlation between Mean Platelet Volume, Fibrinogen and D-dimer with NIHSS Score Nasution, Putra Fajar; Irina, Rr Sinta; Lubis, Bastian
Jurnal Neuroanestesi Indonesia Vol 13, No 2 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i2.581

Abstract

Introduction: Stroke is a clinical syndrome that develops rapidly due to focal or global brain disorders with symptoms last for 24 hours and potentially cause death. Due to the consideration that this Mean Platelet Volume (MPV) marker is not invasive, easy to do and is in line with the pathogenesis of stroke, researchers are interested in carrying out this research. And hopefully this research can provide information for the world of education and health about changes in MPV, fibrinogen and D-dimer in ischemic stroke patients. So it can be taken as consideration in the early management of ischemic stroke patients. Subject and Methods: This research was an observational study with a cross-sectional design at Haji Adam Malik General Hospital from October to November 2023. The research subjects were stroke patients who were treated in emergency room and met inclusion criteria. This research was to study about correlation of MPV, fibrinogen, and D-dimer with NIHSS scores of ischemic stroke patients. The method used in this research is the Pearson correlation test where data was normally distributed. All statistical tests with a p value 0.05 were considered significant. Results: The mean MPV was 10.4 1.6, while the mean NIHSS value was 19.9 8.7, and there was a statistically significant correlation between the MPV value and the NIHSS score (p0.05). The mean fibrinogen was 421.9 109.3, while mean NIHSS value was 19.9 8.7, and there was a statistically significant correlation between fibrinogen values and NIHSS scores (p0.001). The mean D-Dimer was 8.0 11.3, while the mean NIHSS value was 19.9 8.7, and showed a statistically significant correlation between D-Dimer value and NIHSS score (p0.05). The r value of MPV, fibrinogen, and D-dimer on NIHSS score was 0.494; 0.495; and 0.504. The regression coefficient for MPV variable is 0.093, therefore MPV variable influence on NIHSS variable is positive.Conclusion: There is a strong correlation between D-dimer and the NIHSS score, and a moderate correlation between MPV and fibrinogen with NIHSS score.
Hubungan Mean Platelet Volume dengan Skor Sequential Organ Failure Assessment pada Pasien Sepsis Nasution, Putra Fajar; Primaputra Lubis, Andriamuri; Hanafie, Achsanuddin
Majalah Anestesia & Critical Care Vol 43 No 2 (2025): Juni
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v43i2.344

Abstract

Latar Belakang: Sepsis adalah suatu disfungsi organ yang mengancam jiwa yang disebabkan oleh kelainan regulasi respon host terhadap infeksi. Skor Sequential Organ Failure Assessment (SOFA) digunakan untuk menilai tingkat keparahan penyakit berdasarkan derajat disfungsi organ secara serial. Mean platelet volume (MPV) adalah salah satu parameter trombosit di mana trombosit turut berperan dalam proses inflamasi penyakit infeksi akut dan kronis. Tujuan penelitian ini adalah untuk mengetahui hubungan Nilai MPV dengan skor SOFA pada pasien sepsis.Metode: Penelitian ini merupakan studi observasional dengan metode pengumpulan data secara kohort – prospective. Pengambilan sampel dilakukan secara konsekutif terhadap pasien penderita sepsis di ICU yang memenuhi kriteria penelitian. Analisis korelasi nilai MPV dengan skor SOFA pada pasien sepsis menggunakan uji korelasi Pearson. Semua uji statistik dengan nilai p < 0,05 dianggap bermakna.Hasil: Hasil penelitian didapatkan rerata nilai MPV H1 sebesar 9,20± 1,72 dengan skor SOFA H1 sebesar 7,81 ± 2,66. Hasil analisis statistik menunjukkan nilai r > 0,522 dengan nilai p<0,002. Rerata nilai MPV H3 sebesar 9,47±1,39 dengan skor SOFA H3 sebesar 7,96 ± 2,49. Hasil analisis statistik menunjukkan nilai r > 0,441 dengan nilai p <0,010. Temuan ini mengartikan bahwa terdapat hubungan yang bermakna antara MPV dengan skor SOFA dengan kekuatan korelasi yang kuat.Simpulan: Terdapat peningkatan nilai MPV pada pasien sepsis seiring dengan peningkatan skor SOFA, serta ditemukan hubungan nilai MPV dengan skor SOFA pada pasien sepsis baik di hari pertama maupun hari ketiga.
Co-Authors Bastian Lubis Hanafie, Achsanuddin Irina, Rr Sinta Primaputra Lubis, Andriamuri