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All Journal Jurnal Neuroanestesi Indonesia Jurnal Anestesi dan Terapi Intensif Udayana Jurnal Anestesiologi dan Terapi Intensif
Rozi, Fakhriyadi
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Physics Public Health

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Neuroanesthesia Management in Cavernous Sinus Meningioma Craniotomy Patients Rozi, Fakhriyadi; Prihatno, MM Rudi; Cahyono, Iwan Dwi
Jurnal Neuroanestesi Indonesia Vol 13, No 1 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i1.583

Abstract

AbstractThe most prevalent primary cavernous sinus (CS) lesion is cavernous sinus meningioma (CSM). Of all intracranial neoplasms, 1% are tumors in CS, and 41% are CSM. For contemporary neurosurgeons, orbital involvement in cavernous sinus meningiomas (CSMs) poses special difficulties. The condition is known as cavernous sinus meningioma (CSM) gradually impairs vision and may ultimately result in chiastic compression. Since January 2023, a male 55-year-old had been admitted to the hospital with cephalgia and mild diplopia in his right eye. Cavernous meningiomas were discovered using CT scans, and a craniotomy procedure was scheduled to remove the tumor. In order to facilitate intubation, the patient was given a premedication of sufentanyl for analgesia and was then given general anesthesia. Rocuronium was used to relax the muscles. Desflurane is an attractive option available to anesthesiologists to maintain general anaesthesia. This surgical procedure of removing intracranial tumours requires proper induction and monitoring of the patient's condition during surgery to prevent increased intracranial pressure. Intracranial elevation can cause systemic changes such as hypertension and changes in heart rhythm, as well as cerebral artery spasm, and lead to cerebral infarction and cerebral ischemia. An effective neuroanesthesia management program can help preserve hemodynamic stability and improve results during craniotomy surgery for the removal of meningiomas.
Comparison of IL-6 Levels After Ibuprofen–Paracetamol– Dexamethasone in Percutaneous Nephrolithotomy Patients: an Analytic Observational Study Rozi, Fakhriyadi
Jurnal Anestesiologi dan Terapi Intensif Vol. 1 No. 3 (2025): JATI Desember 2025
Publisher : Udayana University and Indonesian Society of Anesthesiologists (PERDATIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/5xdehe52

Abstract

Introduction: Percutaneous Nephrolithotomy (PCNL) is the therapeutic procedure of choice for kidney stones. IL-6 secretion is stimulated during a secondary inflammatory response due to tissue injury or infection. Proper administration of analgesics can reduce morbidity rates, reduce treatment days, and reduce financing. Patients and Methods: An analytical observational study with a cross-sectional design at Purwokerto tertiary hospital in the period from December 2024 to January 2025 in patients undergoing PCNL procedures and receiving ibuprofen, paracetamol, and dexamethasone therapy, which met the inclusion and exclusion criteria. The observational group (15 patients each) was: Group A 1000 mg paracetamol and 400 mg ibuprofen and 5 mg dexamethasone; Group B 1000 mg paracetamol and 400 mg ibuprofen. IL-6 levels were measured before and 2 hours after the PCNL procedure. IL-6 levels were measured by ELISA (enzyme-linked immunosorbent assay). Comparative analysis of pre- or post-PCNL IL-6 levels by type of analgesic using unpaired t-test, while the comparison of changes in IL-6 levels was analyzed with the Mann-Whitney test. To determine whether the data distribution was normal, we used the Shapiro-Wilk test. The analysis used SPSS version 25. Results: Pre- and post-PCNL IL-6 levels were significantly lower in Group A compared to Group B (p < 0.05). However, changes in IL-6 levels were not statistically significant (p = 0.787). Effect size analysis indicated only a small and clinically negligible difference. Conclusion: There was no significant difference in IL-6 levels post-PCNL between the two observation groups.
Comparison of IL-6 Levels After Ibuprofen–Paracetamol– Dexamethasone in Percutaneous Nephrolithotomy Patients: an Analytic Observational Study Rozi, Fakhriyadi
Jurnal Anestesiologi dan Terapi Intensif Vol. 1 No. 3 (2025): JATI Desember 2025
Publisher : Udayana University and Indonesian Society of Anesthesiologists (PERDATIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/5xdehe52

Abstract

Introduction: Percutaneous Nephrolithotomy (PCNL) is the therapeutic procedure of choice for kidney stones. IL-6 secretion is stimulated during a secondary inflammatory response due to tissue injury or infection. Proper administration of analgesics can reduce morbidity rates, reduce treatment days, and reduce financing. Patients and Methods: An analytical observational study with a cross-sectional design at Purwokerto tertiary hospital in the period from December 2024 to January 2025 in patients undergoing PCNL procedures and receiving ibuprofen, paracetamol, and dexamethasone therapy, which met the inclusion and exclusion criteria. The observational group (15 patients each) was: Group A 1000 mg paracetamol and 400 mg ibuprofen and 5 mg dexamethasone; Group B 1000 mg paracetamol and 400 mg ibuprofen. IL-6 levels were measured before and 2 hours after the PCNL procedure. IL-6 levels were measured by ELISA (enzyme-linked immunosorbent assay). Comparative analysis of pre- or post-PCNL IL-6 levels by type of analgesic using unpaired t-test, while the comparison of changes in IL-6 levels was analyzed with the Mann-Whitney test. To determine whether the data distribution was normal, we used the Shapiro-Wilk test. The analysis used SPSS version 25. Results: Pre- and post-PCNL IL-6 levels were significantly lower in Group A compared to Group B (p < 0.05). However, changes in IL-6 levels were not statistically significant (p = 0.787). Effect size analysis indicated only a small and clinically negligible difference. Conclusion: There was no significant difference in IL-6 levels post-PCNL between the two observation groups.
Co-Authors Iwan Dwi Cahyono Prihatno, M. Mukhlis Rudi