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All Journal Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Sains Biomedis
Benedikta Diah Saraswati
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Association of fat mass and obesity associate (FTO) single nucleotide polymorphisms in the first intron and obesity risk among Indonesians Benedikta Diah Saraswati; Luluk Yunaini; Dwi Anita Suryandari
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11771

Abstract

Obesity is one of the global pandemics characterized by an excessive fat buildup due to disruption of energy homeostasis in the body. As obesity is a risk factor for many other non-communicable diseases such as diabetes and coronary heart disease, it is crucial to understand the risk factors that contribute to the pathogenesis of obesity. Although obesity is mainly caused due to unhealthy lifestyles, genetic predisposition also plays a part in the pathogenesis of obesity. Individuals who carry risk alleles for genes that control energy balance in the body have a greater risk of developing obesity. Fat mass and obesity associate (FTO) is a gene strongly correlated with obesity and is widely expressed in the hypothalamus. This gene is predicted to have 89 common variations that affect obesity-related phenotypes. Among Indonesians, the three most studied single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene are rs1421085, rs17817449, and rs9939609. They are strongly associated with obesity’s related traits such as weight gain, fat mass, body mass index (BMI), waist, and hip sizes. rs993609 is the most studied among diverse ethnicities in Indonesia, with AA genotype and allele A as a risk allele.
TROMBOSITOPENIA DAN HEMORAGIK PADA ANAK DENGAN DEMAM BERDARAH DENGUE (DBD): KAJIAN LITERATUR Miftahuz Zakiyah; Ilham Fathurrahman; Nadya Syarifatul Fajriyah; Suharno Zen; Yuda Nabella Prameswari; Benedikta Diah Saraswati
Jurnal Sains Biomedis Vol. 1 No. 02 (2025): Jurnal Sains Biomedis
Publisher : Prodi Sains Biomedis Fakultas Ilmu Kesehatan Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/biomedis.v1i02.10612

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major cause of morbidity among children in Indonesia. Thrombocytopenia is one of the key hematological abnormalities associated with progression to hemorrhagic manifestations.This review aims to summarize current evidence related to thrombocytopenia and clinical hemorrhagic features in pediatric DHF based on several Indonesian studies. A narrative review was conducted using 20 references focusing on pediatric DHF, thrombocytopenia, clinical manifestations, and disease severity.Data from the reviewed studies indicate that thrombocytopenia occurs in more than 70% of DHF cases and typically worsens around days 3–7 of fever. Hemorrhagic manifestations such as petechiae, gum bleeding, and prolonged fever duration are associated with lower platelet count and higher disease severity. Nutritional status, duration of fever, and clinical progression also influence the degree of hemorrhage in children. Thrombocytopenia is a consistent predictor of hemorrhagic complications in pediatric DHF. Early recognition of platelet decline and clinical bleeding signs is crucial in preventing progression to severe dengue.
Co-Authors Dwi Anita Suryandari Ilham Fathurrahman Luluk Yunaini Miftahuz Zakiyah Nadya Syarifatul Fajriyah Suharno Zen Yuda Nabella Prameswari