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All Journal Jurnal Neutrino : jurnal fisika dan aplikasinya Journal of Biomedicine and Translational Research Berkala Kedokteran Jurnal Ilmu Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Health Sains Bioscientia Medicina : Journal of Biomedicine and Translational Research Makara Journal of Science Indonesian Journal of Medical Chemistry and Bioinformatics Journal of Global Pharma Technology Indonesian Journal of Biomedicine and Clinical Sciences
Dwi Anita Suryandari
Department Of Medical Biology, Faculty Of Medicine, Universitas Indonesia, Jakarta 10430
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Differences in Age and Body Mass Index of Women with Polycystic Ovary Syndrome Attending in Vitro Fertilization (IVF) Program Roselina Panghiyangani; Husnul Khatimah; Dwi Anita Suryandari; Budi Wiweko; Mala Kurniati
Berkala Kedokteran Vol 15, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.991 KB) | DOI: 10.20527/jbk.v15i1.6088

Abstract

Abstract: Nutritional status in this case BMI in women is very important in relation to infertility problems in women of reproductive age. Polycystic ovary syndrome (PCOS), is a reproductive problem with hormonal disorders. Infertility Female with PCOS is associated with anovulation, high LH and hyperandrogenism. The purpose of this study was to analyze differences in age and body mass index (BMI) of PCOS women undergoing in vitro fertilization (IVF). This was an observational analytic study. The subjects of the study were women aged 30-40 years who undergoing IVF-assisted fertilization program at Yasmin Clinic - RSCM Kencana who was diagnosed as PCOS. As a comparison are women 30-40 years who have infertility problems but not PCOS  who underwent IVF-assisted fertilization program. Women diagnosed with PCOS based on the Rotterdam 2003 consensus definition, and reinforced with ultrasound examinations that show polycystic ovary symptoms. Diagnosis is performed by a specialist in Obstetrics and Gynecology. Age data is taken from medical record and IMT data is calculated based on formula body weight/height2. Data analysis was done by unpaired t test. Mean age of study subjects: 32.21 ± 0.99 years female PCOS and 32.80 ± 0.516 years of non-PCOS group of women, unpaired t-test results were not significantly different (p> 0.05). Mass Index PCOS group 24.425 ± 0.585 Kg/m2 and 22.840 ± 0.494 Kg/m2 non-PCOS group, unpaired t-test results were significantly different (p <0.05). Conclusion of this research was in the PCOS women group had significantly higher BMI rates than the group non PCOS woman.
HUBUNGAN KADAR SERUM AMH DENGAN JUMLAH MUTASI PADA GEN PROMOTER AMH (ANTI-MULLERIAN HORMONE) PADA PASIEN SOPK (SINDROM OVARIUM POLIKISTIK) Mala Kurniati; Dwi Anita Suryandari; Budi Wiweko; Pudji Sari; Luluk Yunaini; Roselina Panghiyangani
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 1 (2022): Volume 9 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i1.6482

Abstract

Anti-Mullerian Hormone (AMH) adalah anggota dari kelompok Transforming Growth Factor-β yang berperan penting dalam regulasi folikulogenesis reproduksi wanita. Peningkatan kadar AMH 2-3 kali lipat ditemukan pada pasien SOPK (Sindrom Ovarium Polikistik) dibandingkan dengan wanita dengan ovulasi normal. Tujuan dari penelitian ini adalah untuk mengetahui hubungan kadar serum AMH dengan jumlah mutasi pada gen promoter AMH (Anti-Mullerian Hormone) pada pasien SOPK (Sindrom Ovarium Polikistik). Besar sampel adalah 114 pasien yang terdiri dari 60 pasien SOPK dan 54 pasien bukan SOPK sebagai kontrol. Kadar AMH didapatkan dari rekam medis pasien di Klinik Yasmin IVF RSCM Kencana Hospital, Jakarta. Analisis molekuler dan genotipe dilakukan dengan PCR dan sekuensing dilanjutkan dengan analisis bioinformatika. Terdapat 60 mutasi titik pada varian promotor gen AMH. Jenis mutasi varian tertinggi yang ditemukan adalah -674 G/A (100%), diikuti oleh -245 C/CT (88,2%), dan -444 A/G (17,9%) di seluruh sampel. Berdasarkan hasil uji Wilcoxon Signed Rank test, jumlah mutasi pada kelompok SOPK berpengaruh nyata terhadap AMH serum (p<0,05). Pada kelompok kontrol, jumlah mutasi tidak berpengaruh nyata terhadap kadar AMH (p>0,05). Jumlah mutasi pada promotor gen mempengaruhi kadar serum AMH pada PCOS.
Gene Expression of Sperm Associated Antigen 8 and Ran-Binding Protein 9 on Azoospermic Male : Its Association with Spermatogenic Arrest Christina Agusta Deviana Tanifan; Dwi Anita Suryandari; Luluk Yunaini
Jurnal Health Sains Vol. 3 No. 9 (2022): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v3i9.591

Abstract

Proteins that play an  important role in the transcription process during spermatogenesis are CREMs that bind to their ACT activators that are suspected to be regulated by SPAG8 and RANBP9. Until now the role of both genes in the spermatogenic arrest process is not known. This study aims to determine the relative expression of Spag8 and RanBP9 on spermatogenic arrest and to analyze the correlation of expression of both genes. This study is a cross sectional study using a sample of testicular biopsy with Johnsen 2 to 8 score. Relative expression analysis of Spag8 and RanBP9 using qRT-PCR technique with Livak calculation. The data obtained were analyzed statistically using ANOVA one way test for Spag8 and Kruskal Wallis test for RanBP9 with significance value p <0,05. The results of this study show that the relative expression of Spag8 and RanBP9 is highest on Johnsen 3 scores and is statistically significantly different (p <0.05). There is a positive correlation with a very strong correlation strength between SPAG8 and RANBP9 expressions. Based on the results of this study shows that both of these genes are candidates for spermatogenic arrest.
THE EFFECT OF STATIC MAGNETIC FIELD EXPOSURE ON BODY WEIGHT AND ADIPOSE CELLS DENSITY OF OBESE MICE Puji Sari; luluk yunaini; Widia Bela Oktaviani; Umiatin Umiatin; Anita Dwi Suryandari
Jurnal Neutrino:Jurnal Fisika dan Aplikasinya Vol 15, No 1 (2022): October
Publisher : Department of Physics, Maulana Malik Ibrahim State Islamic University of Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/neu.v15i1.16302

Abstract

Obesity is a mojar public health problem in worldwide, especially in Indonesia. Obesity in addition to affecting productivity, is also trigger for other chronic disease such as diabetes and cardiac disease. Body mass index is an assessment tool used to assess degree of individual adiposity to define overweight, obesity, and severe obesity.The determination of obesity is based on the calculation of Body Mass Index (BMI), which devide body weight (kg) by height (cm2). In addition to the method of regulating diet, exercise, and bariatric surgery for weight loss, it was reported that the biophysical therapy tool, that is static magnetic field (SMF) became a modality for weight loss. Based on research reports, it proves that the static magnetic field affects weight loss in the group of obese mice after 30 days of exposure. Therefore, in this study, we carried out static magnetic field exposure to obese mice with a field intensity of 2 mT for 1 hour/day. Mice were exposed gradually to SMF on 2, 7, 14, and 21 days to determine the effectiveness of SMF to obesity in mice in terms of weight loss and cellular adipose cell density. The results showed that the weight of mice decreased significantly on 2nd and 7th days of exposure, the trend showed a decrease in body weight until the 14th day. The density of adipose tissue is increased after exposure to SMF on the 14th and 21st days of exposure. It showed that early exposure to SMF (2 and 7 days) could induce weight loss in mice, while cellularly SMF increased adipose cell density on late exposure (14 and 21 days).
DNA METHYLATION IN THYROID-STIMULATING HORMONE GENE: PREDICTOR OF GRAVE’S DISEASE RECURRENCE IN INDONESIA Luluk yunaini; Dwi Anita Suryandari; Trisia Lusiana Amir; Dwi Yanti; Fatimah Eliana
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Thyroid-stimulating hormone receptor (TSHR) has a critical role in Graves’ disease (GD). GD is an autoimmune disease which is multifactorial. Environmental factors can affect the epigenetic, a changes in gene expression without any changes in base sequence of the DNA. One of the epigenetic types is methylation. This study aims to determine the status of DNA methylation in TSHR gene in patients with GD to be one of the predictors of recurrence. This study used a case control design with 58 samples of GD patients divided into 29 groups of recurrence and 29 groups of non-recurrence. DNA methylation examination used methylation-specific PCR (MSP) method. Our result found that DNA methylation profile of GD in Indonesia were 5% with complete DNA methylation, 17% complete DNA unmethylation and 78 partial DNA methylation. Statistical analysis showed no significant different between recurrence and non-recurrence group (p>0.05). Nevertheless, our result showed no patient with complete status DNA methylation was found in recurrence group. This shows that in recurrence occur a reduction of DNA methylation resulting in increasing of TSHR production. Thus, DNA methylation in TSHR gene might be has a role in the risk of recurrence GD.
Genetic Variation of At-Hook Transcription Factor (Akna) Rs3748178 is Associated with the Relapse of Graves’ Disease Dwi Anita Suryandari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: As many as 30-60% of patients with Graves' disease (GD) have relapsed after antithyroid withdrawal, which may be caused by genetic variation of susceptibility factors. This study aimed to analyze the genetic variation of AT-hook transcription factor AKNA rs3748178 and its association with relapse in Graves' disease patients.Methods: This research was a case-control study examining 60 DNA samples of GD patients, who were equally allocated into relapse and remission groups. Genetic variation was analyzed with PCR-RFLP. Fisher's exact test was used for statistical analysis and a p-value less than 0.05 was considered significant.Results: The proportion of patients who experienced a relapse with homozygote wild type (n= 27, 90%) was significantly higher (p= 0.015) compared to the heterozygote and homozygote mutant (n=3, 10%). Graves’ disease patients with GG genotype were more likely to have a relapse (OR 6.00, 95% CI 1.48–24.3, p= 0.015). The proportion of patients who experienced a relapse with G allotype (95%) was significantly higher (p= 0.004) compared to A allotype (5%). Graves’ disease patients with G allotype were more likely to have a relapse (OR 6.33, 95% CI 1.73–23.2, p= 0.004).Conclusions: Genetic variation of AT-hook transcription factor AKNA rs3748178 is associated with relapse in GD patients.Keywords: Graves’ disease, recurrence, genetic variation
Pengaruh Pajanan Toluena Terhadap Gambaran Sel Spermatogonia A Rattus Strain Wistar Muhammad Ilyas Iqbal; Muchtaruddin Mansyur; Pudji Sari; Dwi Anita Suryandari; Pramudianto
Majalah Kedokteran Indonesia Vol 71 No 1 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.1-2021-349

Abstract

Intoduction: Acute and chronic exposure to toluene at high doses is known to affect all organs of the body including the spermatogenesis process. In the industrial sector, the use of toluene as a solvent is still widely used, up to 10 million tons per year. The control over health problems that may occur is carried out by applying work exposure threshold values. This research aims to explore the effect of toluene exposure at the threshold value range on spermatogenesis.Method: This research used laboratory experiment on 30 male Wistar rats which were divided into five groups of different exposure levels, namely 12.5 parts per million (ppm], 25 ppm, 50 ppm, 100 ppm, and no exposure (control). Exposure was given for 4 hours daily over 14 days through a hood with measured release in the glass cage. The toluene exposure markers observed were Malondialdehyde (MDA) in the blood tissue and testicles using the Thiobarbituric Acid Reactive Substances (TBARS) method. The effect on the spermatogenicity process was assessed by counting the spermatogonia A cells of male Wistar rats with Periodic Acid Schiff (PAS) staining and is calculated by the Abercrombie formula. Analysis of the correlation between the level of exposure and its effect on the increase in malondialdehyde, and spermatogenesis was carried out using the Spearman correlation analysis.Result: There was a moderately positive correlation between levels of toluene exposure and plasma MDA levels (r = 0.42; p = 0.025). Meanwhile, on [the issue of] the quantity of spermatogonia cells, a high level of negative correlation with exposure levels was obtained (r = -0.68; p = 0.001).Conclusion: Toluene exposure in male Wistar rats within the range of threshold values influenced the increase in plasma MDA levels and decreased the Spermatogenia A cells. However, toluene exposure did not affect the testicular MDA levels of male Wistar rats.
PENGARUH PENYUNTIKAN DOSIS MINIMAL DEPOT MEDROKSIPROGESTERON ASETAT (DMPA) TERHADAP BERAT BADAN DAN KIMIA DARAH TIKUS JANTAN GALUR SPRAGUE-DAWLEY Yurnadi, Yurnadi; Suryandari, Dwi Anita; Moeloek, Nukman
Makara Journal of Science Vol. 13, No. 2
Publisher : UI Scholars Hub

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Abstract

Effect of Injection Minimal Dosages of Depot Medroxyprogesterone acetate (DMPA) to Body Weight and Blood Chemistry Male Rat Strain Sprague-Dawley. Many family planning program focus more on men. Until now, vasectomy has been the commonly used method for male contraception. However, this method creates inconvenience such as irreversibility and psychological problems. One of the alternatives contraception is the combination of depot medroxyprogesterone acetate (DMPA) and androgen. The minimum dosage of DMPA could suppress testosterone level that leads to reduced spermatogenesis and sperm viability. Nevertheless, until now it is not known whether minimum dosages of DMPA have an effect to body weight and blood chemistry. Therefore, this research aimed at determinate the effect of minimal dosages of DMPA to body mass and blood chemistry using male rats (Rattus norvegicus L.) strain Sprague-Dawley as model. This research using completely randomized design, unequal size sample, castration treatments and several doses DMPA (1.25, 0.625, and 0.313 milligram). Injecting of DMPA conducted intramuscularly on week 0 and week 12. Normality/homogeneity Data normality were analyzed before ANOVA test. Then, abnormal data were tested using Kruskal-Wallis test. The result shows that injection of DMPA in various doses do not have an effect on body weight and blood chemistry such as erytrocytes, haemoglobin, hematocrite, HDL, LDL, total cholesterol, SGOT, SGPT and triglyseride) (p>0,05). Furthermore, it is concluded that that no effect of minimal dosages of DMPA to body mass and blood chemistry of rat.
COMBINATION OF DEPOT MEDROXY PROGESTERONE ACETATE AND JAVANESE LONG PEPPER EXTRACT ON BODY WEIGHT, HEMATOLOGY, AND BLOOD BIOCHEMISTRY AS A SAFE CONTRACEPTION MODEL Yurnadi, Yurnadi; Asmida, Yoel; Suryandari, Dwi Anita; Moeloek, Nukman
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

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Abstract

The development of male hormonal contraception is based on a decrease in sperm concentration without affecting libido and sexual potency. The combination of depot medroxy progesterone acetate (DMPA) + extract of Javanese long pepper (JLP) with dosages of 0.94 mg and 1.88 mg decreases the concentration of spermatozoa. However, it remains unknown whether the combination influences body weight, hematology, and blood biochemistry. Therefore, it is necessary to investigate the effect of DMPA + JLP extracts on the body weight, hematology, and blood biochemistry of male rats (Rattusnorvegicus L.) using Sprague-Dawley strains. The research uses a completely randomized design (CRD); one group control and two treatment groups. In the first group, the castrated rats were given oral administration extracts of JLP (CJ) with doses of 0, 0.94, 1.88, 2.82, and 3.76 mg. In the second group, the rats were injected with 1.25 mg DMPA and given an oral administration extract of JLP. Injection was given in week-0 and 12. Administration was conducted every day from week 7-18. Analysis of the normality and homogeneity of data is done before the ANOVA test. Data that is abnormal and not homogeneous are tested with non-parametric statistical Kruskal-Wallis. This study shows that the combination of minimal doses of DMPA and administration variousdoses of extracts of JLP does not affect body weight and hematology (erythrocyte, hemoglobin, hematocrite), and the blood biochemistry of rats, such as the values of SGPT, SGOT, HDL, and triglycerides (p < 0.05), but rather the total cholesterol and LDL (p < 0.05). Furthermore, it is concluded that the combination of the minimal dosage of DMPA and weaned various dosages of JLP extracts affect the total value and LDL cholesterol but do not influence body weight, nor hematology and blood biochemistry. Such combinations can be drawn on for asafe male contraceptive model t by taking into account the value of the total cholesterol and LDL during its use.
Association between Macrophage’s Cell Number and Maternal Factors in Human Milk Khudri, Ghaniyyatul; Sukmawati, Dewi; Barasila, Atikah Chalida; Suryandari, Dwi Anita
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Infant nutrition and immune protection require the consumption of human milk, with macrophages mainly contributing to immune defense and infant development. This study was performed to investigate the correlation between macrophage cell numbers in human milk and various maternal factors. Thirteen human milk samples were collected from lactating mothers and were evaluated for macrophage cell numbers using a hemacytometer. The recorded questionnaire containing several questions, including age, multivitamin consumption, coronavirus disease 2019 vaccination status, allergy history, and lactation duration, was used to determine the maternal factors. Pearson’s correlation and Mann-Whitney test was employed in statistical analysis, with p-values < 0.05 considered significant. The macrophage cell number reached 54.236 ± 7.456 cells per mL. Notably, a significant correlation was observed between maternal allergy history and the number of macrophage cells in human milk (p = 0.049). Meanwhile, no statistically significant associations were detected among multivitamin consumption (p = 0.833), vaccination status (p = 0.923), and lactation duration (p = 0.236). This study emphasizes the effect of maternal characteristics on the composition and immune properties of human milk. The specific mechanisms underlying these correlations and their potential influence on infant health and development must be explored in future research.
Co-Authors Arleni Bustami Barasila, Atikah Chalida Benedikta Diah Saraswati Budi Wiweko Christina Agusta Deviana Tanifan Dewi Sukmawati Dwi Yanti Dwira, Surya Fatimah Eliana Fatimah Eliana Ghaniyyatul Khudri Hadi Sunaryo Irandi Putra Pratomo Khaerunissa Anbar Istiadi Khatimah, Husnul Kristanty, Diyah Kurniati, Mala Luluk Yunaini Mala Kurniati Muchtaruddin Mansyur Muhammad Ilyas Iqbal Nukman Moeloek Nukman Moeloek Nukman Moeloek Panghiyangani, Roselina Pramudianto Prawiningrum, Aisyah Pudji Sari Pudji Sari Puji Sari Puji Sari Puji Sari Ria Kodariah Trisia Lusiana Amir Umiatin, Umiatin Widia Bela Oktaviani Yoel Asmida Yoel Asmida Yuda Nabella Prameswari Yurnadi Yurnadi