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All Journal Paediatrica Indonesiana Archives of Pediatric Gastroenterology, Hepatology, and Nutrition
Ramadhanty, Mutiara
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Health Professions Medicine & Pharmacology

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The Predictive Value of Gamma-Glutamyl Transferase on Jaundice Clearance in Biliary Atresia: An Evidence-Based Case Report and Meta-Analysis Toding, Megan Quinka D; Munir, Awliya Syamsul; Ramadhanty, Mutiara; Wiyono, Lowilius
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 3 No. 3 (2024): APGHN Vol. 3 No. 3 August 2024
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.3.3.2024.20-31

Abstract

Background: Biliary atresia (BA) is a neonatal condition characterized by the obstruction of extrahepatic bile ducts. Case: A 2-year-old female with BA underwent a Kasai procedure at 3 months of age. Despite the surgery, she developed persistent jaundice and abdominal enlargement. Preoperative laboratory findings revealed elevated liver enzymes, GGT, and bilirubin levels. This case raises the clinical question of whether preoperative GGT levels can predict JC after the Kasai procedure, in addition to its role in diagnosis. Methods: A systematic literature search was performed on 4 databases (PubMed, Scopus, Cochrane, and Proquest) by using relevant keywords and identified seven high quality studies. Results: Five studies found higher GGT levels in patients who achieved JC following Kasai surgery, compared to those with unsuccessful jaundice clearance (JUC). However, two studies reported conflicting findings. A pooled analysis indicated a non-significant trend toward higher GGT levels in the JC group compared to the JUC group (WMD: 65.6, 95% CI: -58.6; 189.8). Conclusion: Elevated preoperative GGT levels may be associated with improved JC in BA patients. However, further investigation to validate these findings, determine the optimal role of GGT in assessing prognosis, and later, guiding treatment decisions in BA patients.
Virtual learning due to covid-19 pandemic and body weight changes in children aged 6-12 years Aulia, Nadhira Haliza; Santoso, Andintia Aisyah; Ramadhanty, Mutiara; Wirawan, Bintang; Soesanti, Frida
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.509-16

Abstract

Background The COVID-19 pandemic has led to school closures and virtual learning implementation. The situation has affected children's lifestyles and created an obesogenic environment. Objective To evaluate the impact of virtual learning during the pandemic on body weight changes in children. Methods This cross-sectional study was conducted on 6-12 years age children who experienced virtual school learning in Jakarta, Indonesia. Parents or guardians were asked to complete an online questionnaire about lifestyle changes and children's anthropometric data both before and during the virtual learning period. Changes in the weight-for-age Z-score (WAZ) and BMI Z-score (BMIZ) were analyzed using the Wilcoxon signed-rank test. Results A total of 206 children were assessed. There was a significant relation between virtual learning due to the COVID-19 pandemic and WAZ and BMIZ changes among children aged 6-12 years. Approximately 64% of the children experienced WAZ decrement (P value = 0.000), and 77.1% experienced BMIZ decrement (P value = 0.000). Conclusion This study do not align with existing studies' indicating that the pandemic lead to weight gain in children. Instead, the results shows that virtual learning period causes both WAZ and BMIZ to decrease.
Co-Authors Aulia, Nadhira Haliza Bintang Wirawan Munir, Awliya Syamsul Santoso, Andintia Aisyah Soesanti, Frida Toding, Megan Quinka D Wiyono, Lowilius