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Syafiqa Amelia, Dinda
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Potensi buah zanthoxylum acanthopodium dc. dalam menghambat kanker rongga mulut Syafiqa Amelia, Dinda; Sandra, Ferry; Ihsan Rizal, Muhammad
Jurnal Kedokteran Gigi Terpadu Vol. 6 No. 1 (2024): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v6i1.20954

Abstract

Background(s): Oral cancer is one of the most highly prevalent cancers with high mortality rate. Advanced-stage cancer often treated with chemotherapy. Chemotherapy does not differentiate between killing tumor cells and normal cells, leading to a range of side effects. Identifying effective approaches with minimal side effects for cancer treatment remains a significant priority within the medical field. Objective(s) : This review aimed to investigate potential avenues for future research on oral cancer using Z. acanthopodium  Method(s) : References for this article were determined through searches of PubMed, Google Scholar, and official websites of global health organizations. The search terms were “cancer”, “oral cancer”, “anticancer”, “Zanthoxylum acanthopodium”, “apoptosis” from 2014 to 2024. Main finding(s) : Phytochemical compounds found in plants have a significant role in cancer therapies. Z. acanthopodium fruit has been used in anticancer research due to its wide array of bioactive compounds. Previous studies have shown the anticancer properties of Z. acanthopodium DC.  against blood and breast cancer cell lines. Research on its anticancer activity against oral cancer has never been reported. Conclusion(s) : Recent findings confirm Z. acanthopodium as a rich source of bioactive compounds with potential anticancer properties. Further research on its anticancer activity against oral cancer should be promoted.
Penatalaksanaan Oral Lichen Planus et causa Stres Psikologis Nova Fitri, Andrian; Syafiqa Amelia, Dinda
Jurnal Kedokteran Gigi Terpadu Vol. 7 No. 1 (2025): Jurnal Kedokteran Gigi Terpadu
Publisher : Fakultas Kedokteran Gigi Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jkgt.v7i123891

Abstract

Background : Lichen Planus is an autoimmune condition suspected to be an abnormal T-cell immune response targeting the basal epithelium, which is perceived as a foreign body. This leads to alterations in the cell surface and results in persistent inflammation. Clinically, it commonly presents in six forms: reticular (Wickham’s striae), erosive, atrophic, plaque-like, papular, or bullous lesions. The etiology of Oral Lichen Planus (OLP) remains unknown; however, several predisposing factors are believed to be associated with its manifestation, including immunodeficiency, allergies, psychological stress, mucosal trauma, genetic predisposition, and adverse drug reactions.Objective: To inform the patient about the lesion on the buccal mucosa and to determine an appropriate treatment plan. Case Report: A 62-year-old male patient come to RSGM-P Faculty of Dentistry, Universitas Trisakti, with complaints of reddish-white patches on the inner cheeks (both left and right) accompanied by pain. Conclusion: The diagnosis was established based on patient history and clinical examination, identifying Oral Lichen Planus triggered by psychological stress. Management included symptomatic therapy with corticosteroid (prednisone), along with communication, instruction, and patient education.
Co-Authors Andrian Nova Fitri Ferry Sandra Ihsan Rizal, Muhammad