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All Journal Jurnal Indah Sains dan Klinis
Peri Aisyah Zubaidi
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Dentistry Health Professions Medicine & Pharmacology Nursing

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Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Zebua, Nilsya Febrika; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Abstract

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
Pola Penggunaan Obat Analgetik Antiinflamasi Nonsteroid di Pelayanan Farmasi IGD RSUD. Dr. Pirngadi Medan Syamsul, Darwin; Fidiah Suryaningsih; Peri Aisyah Zubaidi
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.03

Abstract

Background: Pain is the main reason why patients come to the Emergency Room (IGD) with a prevalence of 78-86%. Non-steroidal anti-inflammatory Drugs (NSAIDs) are widely used to treat mild to moderate inflammatory pain. This study looked at the use of NSAIDs in the emergency room pharmacy services at Dr. Pirngadi Medan. Methods: This non-experimental, retrospective descriptive study was conducted at the Emergency Room Pharmacy Service at Dr. RSUD. Pirngadi Medan from January to June 2019. Results: Of the 11,257 NSAIDs used, mefenamic acid 500 mg three times a day (28.69%), diclofenac sodium 50 mg twice a day (24.96%), meloxicam 75 mg twice a day (2.29%), ketorolac injection 30 mg if needed (42.20%), meloxicam 15 mg suppository (0.07%), and proton suppository (1.79%) were given as needed. Conclusion: The use of NSAIDs in the emergency room at Dr. Pirngadi Medan in the January-June 2019 period had the correct indications, doses, drugs and patients.
Co-Authors Fidiah Suryaningsih Nilsya Febrika Zebua, Nilsya Febrika Risma Yeni Shofian Syarifuddin Sumardi Suprianto Suprianto Syamsul, Darwin