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All Journal JURNAL FARMASIMED (JFM) Jurnal Indah Sains dan Klinis
Andy Febriady
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Dentistry Health Professions Medicine & Pharmacology Nursing

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Formulasi Sediaan Lulur Body Scrub Pelembab Kulit Ekstrak Daun Kedondong (Spondias dulcis) Cucu Arum Dwi Cahya; Andy Febriady; Sri Rezeki Anggriani
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.04

Abstract

Background: Body scrub is a skincare preparation that effectively removes dead skin cells caused by free radicals. Kedondong leaves are a plant with extraordinary wealth, especially its vitamins, namely A, B1, and C, and have a high antioxidant content, so they can be used as a natural moisturizer for the skin. Objective: This research aims to formulate a body scrub containing Kedondong leaf extract. Method: Kedondong leaf extract was formulated with a concentration of 10.0; 15.0; and 20.0%. Evaluation of the body scrub formulation includes organoleptic, homogeneity, pH, irritation and moisture using a skin analysis tool. Results: Research shows that the body scrub formulation with Kedondong leaf extract is homogeneous and has a shape, colour and pH value corresponding to skin pH standards. This formulation also does not irritate and provides adequate moisture for the skin. The formulation with a concentration of 20% (F4) shows the best effectiveness, being able to moisturize the skin up to 47.8%. Conclusion: Kedondong leaves can be formulated into an effective body scrub to improve the condition of dull skin to make it brighter, cleaner and smoother.
Optimization of the Preventive Potential of Andaliman (Zanthoxylum acanthopodium DC) as a Natural Biofilter Against Cigarette SmokeExposure Through TNF-α Expression Situmorang, Novidawati Boru; Andy Febriady
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d1tsbq73

Abstract

Background: Indonesia ranks third in the world for the highest smoking prevalence after China and India. Smokers often smoke both indoors and outdoors, exposing others to harmful cigarette smoke. Cigarette smoke can trigger oxidative stress, which induces the release of pro-inflammatory cytokines such as Tumor Necrosis Factor (TNF-α). Objective: This study aimed to analyze the optimization of andaliman (Zanthoxylum acanthopodium DC) as a natural biofilter against cigarette smoke exposure through TNF-α expression as a potential preventive measure. Methods: An experimental method was used by measuring TNF-α expression in serum isolated from mice blood using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: TNF-α levels measured by ELISA showed that andaliman extract at doses of 50–400 mg/kg body weight significantly reduced TNF-α levels in mice exposed to cigarette smoke compared to the negative control group (p < 0.05). This reduction is likely related to the presence of flavonoids and alkaloids in andaliman, which act as antioxidants and immunomodulators that inhibit inflammatory pathways triggered by oxidative stress from cigarette smoke. With its anti-inflammatory potential, andaliman can be developed as an eco-friendly natural biofilter to prevent the harmful effects of cigarette smoke, although further studies are needed regarding its optimal dosage and long-term safety. Conclusion: Andaliman extract (Zanthoxylum acanthopodium DC) effectively reduced TNF-α levels in mice exposed to cigarette smoke, demonstrating anti-inflammatory potential as a natural biofilter. Its flavonoid and alkaloid content act as antioxidants and immunomodulators that suppress inflammatory pathways induced by cigarette smoke toxins. Andaliman shows promise as an environmentally friendly natural preventive agent to mitigate the negative impacts of cigarette smoke exposure.
Development of Molecularly Imprinted Polymer Materials as Selective Recognition Elements for Electrochemical Meropenem Sensors Herlina, Herlina; Ritonga, Ahmad Hafizullah; Andy Febriady; Asvia Rahayu; Sinaga, Naomi Geraldin
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j884sv81

Abstract

The rising prevalence of bacterial resistance to carbapenem antibiotics, particularly meropenem, highlights the urgent need for rapid, selective, and efficient detection methods. This study reports the synthesis of molecularly imprinted polymers (MIPs) based on methyl methacrylate (MMA) as selective recognition elements for electrochemical meropenem sensors. Bulk polymerization was employed using MMA as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, dimethyl sulfoxide (DMSO) as the porogen, and benzoyl peroxide (BPO) as the initiator. Both non-imprinted polymers (NIPs) and molecularly imprinted polymers (MIPs) were prepared, followed by template extraction through sequential washing with acetonitrile, methanol–acetic acid, and methanol–deionized water to generate specific recognition cavities. Characterization using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed the success of molecular imprinting, as evidenced by the disappearance of characteristic meropenem bands and the formation of porous cavities in the MIP. Adsorption studies revealed that the MIP exhibited a higher adsorption capacity (8.9940 mg/g) compared to the NIP (3.9904 mg/g), yielding an imprinting factor (IF) of 2.25. Selectivity testing against the competing analyte amoxicillin produced a selectivity coefficient (α) of 1.06, indicating preferential binding toward meropenem despite modest discrimination. These results demonstrate that MMA–EGDMA-based MIPs possess promising potential as selective recognition elements for electrochemical meropenem sensors. The developed material not only contributes to the advancement of functional polymer research but also offers practical opportunities for real-time monitoring of antibiotic levels in clinical and environmental samples.
Co-Authors Asvia Rahayu Cucu Arum Dwi Cahya Herlina Herlina Novidawati Boru Situmorang Sinaga, Naomi Geraldin Sri Rezeki Anggriani