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Formulasi Sediaan Masker Pelembab Ekstrak Etanol Kulit Pisang Mas (Musa acuminata L.) Debi Meilani; Cucu Arum Dwi Cahya; Aminah Syarifuddin; Regina Elyanda Tampubolon
Jurnal Indah Sains dan Klinis Vol 3 No 3 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i3.03

Background: Moisturizing cosmetics are care cosmetics that aim to maintain structure and function from various influences. One of the cosmetic preparations for facial skin care is a facial mask. Objective: The research is aimed at formulating and evaluating the Mas banana peel extract moisturizing mask formulation formula. Method: Formulation is carried out by adding the extract to the moisturizing preparation formula and evaluating it, including pH, dry time, spreadability, stickiness, moisture and irritation. Results: The results showed that the Mas banana peel ethanol extract mask preparation obtained had a pH of 6.1 - 6.5, dry time of 16.9 - 25.0 minutes, spreadability of 4.98 - 33.49 cm2, and very adhesive power. firm, average humidity 31.5 -52.9%, no irritation to the skin. Conclusion: A moisturizing mask from the ethanol extract of mas banana peel is effective as a skin moisturizer, equivalent to cosmetics containing 2% glycerin, does not cause skin irritation, has a standard cosmetic pH, and has good spreadability and adhesion

Gambaran Tingkat Pengetahuan dan Kepatuhan Pengunaan Obat Kolesterol Di Puskesmas Mulyorejo Kecamatan Sunggal Debi Dinha Octora; Feronika Sidabutar; Cucu Arum Dwi Cahya; Aminah Syarifuddin
Jurnal Indah Sains dan Klinis Vol 3 No 3 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i3.04

Background: Cholesterol and triglycerides above the normal limit, expressed as hyperlipidemia, have a prevalence that increases with age. An unhealthy lifestyle and rarely exercising are the main causes of hyperlipidemia. Objective: The study aims to determine the level of knowledge and compliance with the use of cholesterol medication at the Mulyorejo Community Health Center, Sunggal District. Method: Research uses quantitative descriptive methods. Quantitative descriptive is a measurement whose data is in measurable numbers. Collection of primary data from questionnaires distributed to respondents determined by random sampling. Benefits: Research can be used as evaluation material in the use of anti-cholesterol drugs at the Mulyorejo Community Health Center, Sunggal District. Results: The study obtained from the 50 respondents studied had good knowledge and were compliant with using cholesterol medication, respectively 51.0 and 53.2%; gender, age, education, and occupation are dominated respectively by women (66.0%), 40 -55 years (64%), high school (46%), and employees (30%). Conclusion: This research proves that the community at the Mulyorejo Community Health Center, Sunggal District, has good knowledge and compliance with the percentage of respondents being 51.0 and 53.2% respectively.

Potensi Antiinflamasi Ekstrak Etanol Daun Sawo Kecik (Manilkara kauki L.) Aminah Syarifuddin; Debi Dinha Octora; Cucu Arum Dwi Cahya
Jurnal Indah Sains dan Klinis Vol 3 No 3 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i3.05

Background: Inflammation often occurs in the community in the joints, its prevalence in the world is around 11.9 million. The prevalence in high-income countries is around 1.3 million, while in low-income countries it reaches 5.9 million, Southeast Asia has 4.4 million. Objective: The study was directed to test the anti-inflation effect of EDSK. Method: The method causes oedema of the soles of the test animals through carrageenan induction. The EDSK test as an anti-inflammatory was used by 25 animals distributed in 5 groups; one positive and one negative control, and 3 treatments each of SND, CMC, SEDSK1, SEDSK2, SEDSK3. Results: The percentage of inflammation in the five groups decreased continuously starting from the first hour to the 6th hour after carrageenan induction. The largest percentage of inflammation occurred at the 2nd hour in CMC, followed by SEDSK1, SEDSK2, SEDSK3 and SND. The greatest percent inhibition was SND, followed by SEDSK3, SEDSK2, and SEDSK1. The best inhibition was on SEDSK3 after SND, followed by SEDSK2, and SEDSK1.Conclusion: Research provides information that the SEDSK1, SEDSK2, and SEDSK3 groups have potential anti-inflammatory agents.

Uji Aktivitas Ekstrak Biji Asam Jawa (Tamarindus indica) terhadap Asam Urat Mencit Putih Jantan (Mus Musculus) Induksi Kalium Oksonat Asti Pratiwi; Aminah Syarifuddin; Cucu Arum Dwi Cahya; Melinda Sari
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.01

Background: The Tropical Tamarind Plant has great economic value and benefits for society, from the stems to the leaves it can be used to treat diseases, such as fever, dyspepsia and even gonorrhoea. The chemical components of Tamarind seeds include alkaloids, saponins, flavonoids, glycosides, malic acid, tartrate, pectin, arabinose, xylose, galactose and glucose. Objective: The study was directed to determine the activity of ethanol extract from tamarind seeds in reducing uric acid in mice. Methods: Preparation of dry extract of Tamarind seeds (EKBAJ), phytochemical screening, and testing the activity of reducing uric acid in mice induced by potassium oxonate at various concentrations of EKBAJ. Measure the levels with Easy Touch GCU. Results: EKBAJ can inhibit mouse uric acid synthesis. The higher the concentration of EKBAJ, the greater the effect on reducing uric acid levels. Conclusion: A concentration of 200 mg/kgBW had the greatest effect on reducing uric acid in mice.

Analisis Dexametason Jamu Pegal Linu di Lubuk Pakam dengan Metode Spektrofotometri Cucu Arum Dwi Cahya; Sri Rezeki Anggriani
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.03

Background: Chemical drugs are prohibited from being contained in traditional medicine doses. Based on BPOM findings in 2015-2017, almost 100 traditional herbal medicine products contain medicinal chemicals (BKO), including dexamethasone. Objective: Study to determine dexamethasone levels and the level of control in herbal medicine for rheumatic pain in the Lubuk Pakam area. Method: The UV-Fis spectrophotometric method was used for quantitative analysis. Meanwhile, for qualitative analysis, the reagents used were the addition of anhydrous acetic acid and concentrated sulfuric acid. Results: Analysis with the addition of this reagent showed that 5 samples contained dexamethasone. UV-Fis spectrophotometric analysis showed dexamethasone levels in samples A1 to A5 were 4.069; 4,229; 4,416; 11,788; and 5,270 mg/g. Conclusion: The research results showed that all five samples contained Dexamethasone at certain levels in the Lubuk Pakam area, North Sumatra

Potensi Aktivitas Ekstrak Etanol Rimpang Kunyit (Curcuma longa) sebagai Antibakteri Escherichia coli Suci Wulandari; Aminah Syarifuddin; Cucu Arum Dwi Cahya; Pebriani Nainggolan
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.04

Background: Turmeric (Curcuma longa) is well known as one of the many medicinal plants in the form of rhizomes, both on a home and industrial scale. The chemical components contained in the rhizomes include fat, ascorbate, protein, starch, tannin, curcumin, flavonoids and essential oils. Turmeric is commonly used by people to reduce the frequency of diarrhea. Apart from having chelating properties, it is also anti-inflammatory and even antibacterial. Objective: The study was directed to investigate the potential of ethanol extract of turmeric rhizomes (EERK) on Escherichia coli. Method: Dry rhizome powder was macerated using 96% ethanol, then rotary evaporated to obtain dry turmeric rhizome extract (EKRK), and divided into concentrations of 30%, 40% 50%, positive or negative control. Results: The study shows that there is an influence of EKRK concentration on the antibacterial potential of Escherchia coli. One-way ANOVA described that there was a significant difference (p < 0.010) in the use of various EKRK concentrations as inhibitors of bacterial growth and development. Antibacterial activity at 30, 40, and 50 % was 14.3, 17.5, and 19.7 mm, respectively. Conclusion: EERK has strong potential as an antibacterial for Escherichia coli.

Potensi Ekstrak Etanol Herba Binara (Artemisia vulgaris L.) sebagai Antibakteri Staphylococcus aureus Arifin Putra Zai; Samran; Aminah Syarifuddin; Cucu Arum Dwi Cahya
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.02

Background: Herb Binara has potential as an antimicrobial against Staphylococcus aureus, because this plant has several compounds that have medicinal properties, including: alkaloids, saponins and flavonoids. This compound can act as a natural antibiotic. Objective: The study was aimed at finding out whether Binara extract has antibacterial potential. Methods: The study was carried out using a disc diffusion system to assess the antibacterial potential of Binara herbal extract. Antibacterial potency is based on the area of obstruction around the disc. The study used four extract concentrations (20, 40, 60, and 80%), clindamycin, and DMSO. Results: Test results for the antibacterial potential of the ethanol extract of Binara herb at a concentration of 80; 60; 40; and 20% each show the resistance area is 12.90; 10.50; 9.00; and 8.10 mm. Conclusion: Binara herb ethanol extract has potential as an antibacterial with moderate to strong potency criteria

Kuantifikasi Vitamin C Petai Cina (Leucaena leucocephala) dengan Spektrofotometri UV-Vis Asti Pratiwi; Aminah Syarifuddin; Cucu Arum Dwi Cahya; Sri Rahayu
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.01

Background: Vitamin C is very soluble in water and is always used for additional nutrition in the form of supplements. This vitamin is needed by the body because it can increase the body's ability to fight disease and function as a neutralizer of radical particles found in the body, usually referred to as antioxidants. One of them is the Petai Cina plant which is used by the community as a savory flavor in dishes, and can also be used as traditional medicine. Objective: To determine the presence and levels of vitamin C in Petai Cina in the Lubuk Pakam regional market. with quality and quantity analysis. Method: Samples were analyzed qualitatively using a specific color reagent for vitamin C and quality was determined using UV spectrophotometry. Results: The standard vitamin C wavelength is 224.5 nm at a concentration of 4 ppm with the regression equation y = 0.0339x + 0.3922. Qualitatively, it is proven that there is vitamin C in Petai Cina with a quantity of 0.1095 mg/mL. Conclusion: Vitamin is found in Petai Cina with a quantity of 0.1095 circulating in the Lubuk Pakam market

Formulasi Sediaan Lulur Body Scrub Pelembab Kulit Ekstrak Daun Kedondong (Spondias dulcis) Cucu Arum Dwi Cahya; Andy Febriady; Sri Rezeki Anggriani
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.04

Background: Body scrub is a skincare preparation that effectively removes dead skin cells caused by free radicals. Kedondong leaves are a plant with extraordinary wealth, especially its vitamins, namely A, B1, and C, and have a high antioxidant content, so they can be used as a natural moisturizer for the skin. Objective: This research aims to formulate a body scrub containing Kedondong leaf extract. Method: Kedondong leaf extract was formulated with a concentration of 10.0; 15.0; and 20.0%. Evaluation of the body scrub formulation includes organoleptic, homogeneity, pH, irritation and moisture using a skin analysis tool. Results: Research shows that the body scrub formulation with Kedondong leaf extract is homogeneous and has a shape, colour and pH value corresponding to skin pH standards. This formulation also does not irritate and provides adequate moisture for the skin. The formulation with a concentration of 20% (F4) shows the best effectiveness, being able to moisturize the skin up to 47.8%. Conclusion: Kedondong leaves can be formulated into an effective body scrub to improve the condition of dull skin to make it brighter, cleaner and smoother.

Formulation and Evaluation of Nanogel from Tubifex Worms (Tubifex sp.) as a Future Therapeutic Agent for Burn Wounds Syarifuddin, Aminah; Cucu Arum Dwi Cahya
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/p1z1pm37

Background: Burns are one of the most common types of injuries found in the community. Burn treatment tends to be relatively expensive, which often leads to suboptimal care and prolonged healing time. Therefore, innovation in pharmaceutical formulations that are more effective, affordable, and based on natural ingredients is needed. One of the widely used dosage forms is semisolid gel, as it is practical, non-sticky, and comfortable to use. Currently, nanogel development has attracted significant attention because it can enhance the absorption of active compounds, provide more controlled drug release, and reduce toxicity. Indonesia, with its rich biodiversity, has great potential for the exploration of natural materials, including the aquatic worm Tubifex sp. Objective: This study aimed to formulate and evaluate Tubifex sp.-based nanogel as a therapeutic agent for burn wounds. Methods: The study employed an experimental method, including physical stability tests of the nanogel and in vivo tests on male white rats with controlled burn injuries. Results: The results showed that all treatment groups experienced progressive wound diameter reduction over 14 days. The negative control showed only 36.6% healing, while the positive control reached 90%. The Tubifex sp. nanogel demonstrated promising results, with formula F1 (3.75%) and F2 (7.5%) achieving 80–86.6% healing, while formula F3 (15%) reached 93.3%, even surpassing the positive control. The effectiveness of the nanogel is believed to be related to the protein, collagen, and antioxidant content in Tubifex sp., which play important roles in tissue regeneration.Conclusion: Tubifex sp. nanogel has the potential to become an innovative, natural-based therapy for burn treatment in the future.

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