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All Journal JURNAL FARMASIMED (JFM) Jurnal Pengmas Kestra (JPK) Medistra Medical Journal (MMJ)
Asvia Rahayu
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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SEMINAR IDENTIFIKASI BAKTERI ESCHERICHIA COLI O157:H7 PADA FESES PENDERITA DIARE DENGAN METODE KULTUR DAN PCR Vincentia Ade Rizky; Sa'adah Siregar; Visensius Krisdianilo; Asvia Rahayu
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 1 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.53 KB) | DOI: 10.35451/jpk.v1i1.746

Abstract

The technique of identifying Escherichia coli O157: H7 bacteria in the feces of diarrhea sufferers using a molecular method, namely PCR has been proven to be more sensitive and shows fast results but is expensive when compared to conventional methods. Therefore, it can be recommended and used by health workers in early detection so that it will help make the diagnosis faster and determine treatment more effectively. The results of this seminar aim to make it easier for laboratory staff to identify the Escherichia coli O157: H7 bacteria in diarrhea sufferers.
Optimizing platelet count assessment: the potential of celery leaves (Apium graveolens linn) as a sustainable alternative to EDTA (Ethylenediaminetetraacetic Acid) H, Herlina; ANGELIKA SINAGA; AGNES OCTAVIA DAMANIK; ASVIA RAHAYU; LASMARYNA SIRUMAPEA
Medistra Medical Journal (MMJ) Vol 1 No 2 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v1i2.2092

Abstract

Seledri (Apium graveolens linn) mengandung flavonoid, fitosterol, vitamin K dan apigenin. Apigenin memiliki sifat sebagai vasodilator, yang memperlebar pembuluh darah dengan cara menghambat kontraksi yang disebabkan oleh pelepasan kalsium, mirip dengan mekanisme kerja antagonis kalsium. Antagonis kalsium bekerja dengan menurunkan tekanan darah melalui pemblokiran masuknya kalsium ke dalam aliran darah, mekanisme tersebut mirip dengan EDTA dan berpotensi sebagai antikoagulan yang menghambat agregasi trombosit. Penelitian ini bertujuan untuk mengevaluasi potensi daun seledri sebagai pengganti EDTA pada pemeriksaan jumlah trombosit. Metode yang digunakan adalah eksperimen, dengan Modifikasi pembuatan larutan seledri pada konsentrasi 30% dan 40%. Hasil pengujian menunjukkan bahwa larutan seledri 40% memberikan hasil hitung trombosit sebesar 196.000 sel/ul dan memiliki efek yang sama dengan antikoagulan EDTA sebagai kontrol. Analisis statistik menunjukkan tidak ada perbedaan signifikan antara seledri dan dengan konsentrasi 40% dengan EDTA, dan hal terbukti lebih efektif sebagai alternatif pengganti EDTA dalam pemeriksaan jumlah trombosit.
Analysis of colifrom bacteria of dishwasting water food stalls in Lubuk Pakam Sitepu, Rahmadani; AHMAD ILHAM; ANGELIKA; ASVIA RAHAYU; RIMAYANI
Medistra Medical Journal (MMJ) Vol 1 No 2 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v1i2.2112

Abstract

Food stalls play a role in helping fulfil daily needs by offering convenient and fast services, so people like to eat food at food stalls. If contaminated cutlery is used, those who use it may be infected with disease-causing microbes. Objective: The purpose of this study was to determine the presence of Coliform bacteria in water both before and after being used to clean food utensils in food stalls around the Medistra Institute of Health Lubuk Pakam. Methods: The method used is quantitative, as well as experimental to test water quality with applicable quality standards and describe the results of research based on literature review. Results: Of the 4 food stalls around the Medistra Institute of Health, it shows that there are 3 food stalls in the category of not meeting health requirements and 1 other food stall in the category of meeting health requirements based on the maximum number of total coliforms for piped and non-piped water 10/100 and 50/100 ml of water samples respectively in accordance with Permenkes No. 416/Per/Menkes/IX/1990. The quality of washing water (clean water) used in food stalls around the Medistra Institute of Health based on the results of laboratory tests of total Coliform, from four food stalls around the Medistra Institute of Health, 3 food stalls in the category of not meeting health requirements and 1 other food stall in the category of meeting the requirements according to Permenkes No. 416/Per/Menkes/IX/1990, concerning clean water quality for piped and non-piped water with numbers 10/100 ml and 50/100 ml of water samples. Keywords : Coliform bacteria, Escherichia coli, Dishwasting Water
Development of Molecularly Imprinted Polymer Materials as Selective Recognition Elements for Electrochemical Meropenem Sensors Herlina, Herlina; Ritonga, Ahmad Hafizullah; Andy Febriady; Asvia Rahayu; Sinaga, Naomi Geraldin
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j884sv81

Abstract

The rising prevalence of bacterial resistance to carbapenem antibiotics, particularly meropenem, highlights the urgent need for rapid, selective, and efficient detection methods. This study reports the synthesis of molecularly imprinted polymers (MIPs) based on methyl methacrylate (MMA) as selective recognition elements for electrochemical meropenem sensors. Bulk polymerization was employed using MMA as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, dimethyl sulfoxide (DMSO) as the porogen, and benzoyl peroxide (BPO) as the initiator. Both non-imprinted polymers (NIPs) and molecularly imprinted polymers (MIPs) were prepared, followed by template extraction through sequential washing with acetonitrile, methanol–acetic acid, and methanol–deionized water to generate specific recognition cavities. Characterization using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed the success of molecular imprinting, as evidenced by the disappearance of characteristic meropenem bands and the formation of porous cavities in the MIP. Adsorption studies revealed that the MIP exhibited a higher adsorption capacity (8.9940 mg/g) compared to the NIP (3.9904 mg/g), yielding an imprinting factor (IF) of 2.25. Selectivity testing against the competing analyte amoxicillin produced a selectivity coefficient (α) of 1.06, indicating preferential binding toward meropenem despite modest discrimination. These results demonstrate that MMA–EGDMA-based MIPs possess promising potential as selective recognition elements for electrochemical meropenem sensors. The developed material not only contributes to the advancement of functional polymer research but also offers practical opportunities for real-time monitoring of antibiotic levels in clinical and environmental samples.
Co-Authors AGNES OCTAVIA DAMANIK Ahmad Ilham Andy Febriady Angelika ANGELIKA SINAGA Herlina H Herlina Herlina Lasmaryna Sirumapea RIMAYANI Sa'adah Siregar Sinaga, Naomi Geraldin Sitepu, Rahmadani Vincentia Ade Rizky Visensius Krisdianilo