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Innovative Utilization of Orange Peel Waste through Modified Citrus Pectin (MCP) as a Preventive Agent Against Atherosclerosis Progression via Galectin-3 (Gal-3) Inhibition: A Comprehensive Literature Review on In Vitro and In Vivo Study Designs Nursyafi, Fauzan Syarif; Febrian, Lamirza Rasyid Mikzy; Putra, Rivaldi Dwi; Renato, Hagil Alghufron; Kurniawan, Dio
JIM - Journal International Multidisciplinary Vol. 2 No. 2 (2024)
Publisher : Rumah Jurnal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jim.v2i2.889

Abstract

Atherosclerosis is an arterial disease often associated with lipids and other metabolic alterations. Various factors are involved in developing atherosclerosis, including Galectin-3 (Gal-3). Pre-clinical studies have shown that Modified Citrus Pectin (MCP), a modified polysaccharide from citrus peels, has the potential of inhibiting Gal-3 and countering the development of atherosclerosis. Thus, this review aims to analyze the role of MCP on inhibiting and regulating Galectin-3 (Gal-3) as an alternative therapeutic target. We examined valid pre-clinical experimental study designs taken from the databases Science Direct, Taylor & Francis, PubMed, and Google Scholar, with publication dates ranging from 2014 to 2024. 15 research articles meet the established inclusion criteria. Our review found that Gal-3 levels rose during atherosclerosis development, triggering proteins that disturbs cardiovascular physiology. Additionally, Gal-3 targeted inhibition using MCP has shown to have therapeutic effects that alleviates hypertrophy and plaque’s size. In essence, MCP emerges as a promising alternative therapy targeting Gal-3 in atherosclerosis progression.
Tafsir Ayat Ayat Tentang Prngaruh Lingkungan Keluarga, Fakultas Dan Sosial Sebagai Pendidikan Haifa, Nurul Melani; Kurniawan, Dio; Kholik, Syafwan
At-Tarbiyah: Journal of Islamic Religious Research and Education Vol. 2 No. 1 (2024): At-Tarbiyah: Journal of Islamic Religious Research and Education
Publisher : STAI Tebing Tinggi Deli

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Abstract

Artikel ini membahas tafsir ayat-ayat Al-Qur'an yang terkait dengan pengaruh lingkungan keluarga, fakultas, dan sosial dalam pendidikan. Dalam perspektif Al-Qur'an, pendidikan dimulai dari lingkungan keluarga yang berfungsi sebagai fondasi utama dalam membentuk karakter, keimanan, dan akhlak anak-anak. Ayat-ayat seperti Surah Luqman (31:13-19) menegaskan pentingnya peran orang tua dalam mendidik anak agar memiliki nilai-nilai agama dan moral yang kuat. Selain keluarga, lingkungan fakultas atau pendidikan formal juga memiliki peran penting dalam perkembangan intelektual dan moral seorang individu. Al-Qur'an mendorong umat Islam untuk menuntut ilmu, yang menjadikan pendidikan sebagai sarana untuk mendekatkan diri kepada Allah SWT. Terakhir, artikel ini juga membahas pengaruh lingkungan sosial dalam pembentukan kepribadian. Al-Quran mengingatkan pentingnya memilih pergaulan yang baik, sebagaimana diungkapkan dalam Surah Al-Furqan (25:27-29), dan berkontribusi dalam menyebarkan kebaikan di masyarakat. Secara keseluruhan, ketiga lingkungan ini keluarga, fakultas, dan sosial bekerja secara sinergis dalam mendidik individu yang berilmu, berakhlak mulia, dan siap berkontribusi positif bagi masyarakat.   Kata Kunci: Al-Qur'an, Pendidikan, Lingkungan Keluarga, Lingkungan Fakultas, Lingkungan Sosial.
PENGARUH EKSPOR DAN INVESTASI TERHADAP PERTUMBUHAN EKONOMI Annisa, Fitra; Rahmadani, Mutiara Arlina; Kurniawan, Dio; Marina, Marina; Muslim, Bukhari; Jolianis, Jolianis
Jurnal Pendidikan Ekonomi (JURKAMI) Vol 11, No 1 (2026): JURKAMI
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpe.v11i1.5886

Abstract

The purpose of this study is to determine and analyze the influence of exports and investment on Indonesia's economic growth, both partially and simultaneously. Data collection techniques used documentation, with data sources obtained from BPS (Central Statistics Agency) Indonesia and the World Bank for the period 1960-2024. Data analysis was conducted using the multiple regression method. The results of the study indicate that exports and investment do not have a significant influence on economic growth, either partially or simultaneously. This indicates that the level of exports and investment does not affect economic growth. One of the causes is unequal economic growth due to disparities between urban and rural areas, as well as between western and eastern Indonesia. This finding indicates that these variables are influenced by other, more dominant factors, so they do not have a strong enough impact on national economic growth. This study suggests the need for more in-depth studies of other variables that can influence economic growth and the importance of more focused policies to increase the contribution of exports and investment. Other factors include: infrastructure, macroeconomic conditions (inflation, interest rates), economic diversification, innovation and technology. This research has time limitations, because it does not cover long-term economic boundaries and the limited variables measured do not include macroeconomic variables as factors that influence economic growth.