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All Journal Journal of Biomedicine and Translational Research Universa Medicina
Tampi, Joan Alexandra
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Comparative efficacy of topical 10% versus 5% tranexamic acid in treatment of women with melasma: a double-blind randomized controlled trial Mawu, Ferra Olivia; Kapantow, Marlyn Grace; Pandaleke, Herry E. J.; Cahyadi, Alexandro Ivan; Togelang, Lidya; Tampi, Joan Alexandra; Christopher, Paulus Mario
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.213-219

Abstract

BackgroundMelasma is a highly prevalent chronic pigmentary disorder. The pathogenesis is unknown but melasma often occurs in photo-exposed areas, e.g., cheeks, upper lip, chin, and forehead. Tranexamic acid (TA), a plasmin inhibitor, aids in the inhibition of UV-induced plasmin activity and melanogenesis, making it a favorable therapeutic option for melasma. Tranexamic acid may be administered through various routes, e.g., topical. This study aimed to compare the efficacy of topical 10% versus 5% TA in women with melasma. MethodsThis double-blind randomized controlled trial included 16 females with epidermal type melasma who were randomized into two groups to receive either topical 10% TA (n = 8) or 5% TA (n = 8) applied twice daily for eight weeks. Prior to intervention and at 8 weeks after intervention, the intensity and extension of melasma were assessed based on melasma area and severity index (MASI) score and pigmentation score. ResultsMean MASI and pigmentation scores in both treatment groups were similar at base-line (p>0.05). The reduction in MASI and pigmentation scores in the topical 10% TA and 5% TA groups was similar and statistically not significant after 4 and 8 weeks of treatment (p>0.05). There were no drug-related adverse reactions or complications. ConclusionThis study demonstrated that topical 10% TA and 5% TA were effective in treating women with melasma. The utilization of topical 5% TA for melasma is a promising alternative therapeutic option without the need to increase the concentration of the formulation.
Successful Management of Post-Excisional Biopsy Dehisced Wound with 1% Framycetin Sulphate and Ozonated Oil Adjuvant: A Case Report Mawu, Ferra Olivia; Sondakh, O. Reymond L.; Tampi, Joan Alexandra; Christopher, Paulus Mario
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25956

Abstract

Background: Wound dehiscence is wound edges separation due to disrupted wound healing. Wound dehiscence is a complication in 8% of dermatologic surgeries. In this case, secondary infection of the wound occurred, 1% framycetin sulphate tulle was then chosen to interfere microbial protein synthesis, combined with ozonated oil as adjuvant therapy. Ozone oxidizes bacterial phospholipids and lipoproteins, promotes local tissue metabolism, stimulates fibroblast proliferation, facilitates collagen fiber formation, and supports angiogenesis. This case report described a post-excisional biopsy dehisced wound that was treated with 1% framycetin sulphate tulle and ozonated oil, and this case is the first to report a successful management of post-excisional biopsy dehisced wound with ozonated oil as adjuvant. Case Presentation: An 11-year-old female was brought with a purulent wound on her head post-excisional biopsy. Examination of the parietal region showed a solitary ulcer, 1 cm in diameter, irregular edge, granulated tissue base, serous exudate, crusting, edema, and pus. Treatment was 0.9% NaCl compress, 1% framycetin sulphate tulle, and ozonated oil once weekly. Evaluation on day 21 showed ulcer size reduction and on day 28, ulcer turned into a scar, treatment was continued with mometasone 0.1% cream. Day 86 showed secondary cicatricial alopecia. Complications of a wound in hair-bearing area can occur, in this case, secondary cicatricial alopecia.Conclusion: This paper highlights the utilization of ozonated oil as an adjuvant therapy for a favorable outcome in wound healing.
Co-Authors Cahyadi, Alexandro Ivan Christopher, Paulus Mario Herry E. J. Pandaleke Lidya Togelang Marlyn Grace Kapantow Mawu, Ferra Olivia Sondakh, O. Reymond L.