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All Journal Journal of Biomedicine and Translational Research Universa Medicina Archives of The Medicine and Case Reports Media Dermato-Venereologica Indonesiana Indonesian Journal of Biomedicine and Clinical Sciences
Mawu, Ferra Olivia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Comparison of Intralesional Triamcinolone Acetonide Alone with Intralesional Triamcinolone Acetonide-5-Fluorouracil Combination Injection in Keloid: A Case Report Mawu, Ferra Olivia; Marlyn Grace Kapantow; Oktavia Reymond L. Sondakh; Elrovita Donata; Paulus Mario Christopher
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.565

Abstract

Keloids are abnormal cutaneous wound healing responses extending beyond the borders of the initial wound, usually appearing pink-purplish to hyperpigmented nodules or plaques with a hard consistency, irregular shape, uneven border, and smooth shiny surface. Most often occur on the chest, shoulder, upper arms, earlobes, and cheeks. This case report aims to compare a case of keloid treated with intralesional triamcinolone acetonide (TAC) alone with intralesional triamcinolone acetonide-5-fluorouracil (TAC + 5-FU) combination injection. A 21-year-old Minahasa male complains of growing pruritic scars in the back area and right and left upper arms since five years ago. Physical examination of the right and left upper arms revealed multiple hyperpigmented nodules and plaques, irregularly shaped, smooth, and shiny surfaces with defined borders and varying sizes. A clinical diagnosis of keloid was made. Treatment was initiated with weekly intralesional TAC alone on the left upper arm vs. intralesional TAC + 5-FU combination injection on the right upper arm. The evaluation was made based on the clinical and modified Vancouver scar scale. One of the most commonly used therapeutic options for keloid is TAC. However, the combination of TAC + 5-FU may be opted for due to its mechanism through the corticosteroid mechanism of action in conjunction with the antimetabolite activity of 5-FU. The combination may yield a more effective and faster outcome with fewer side effects. Intralesional combination TAC + 5-FU injection may be a therapeutic option for keloid with minimal side effects.
Comparative efficacy of topical 10% versus 5% tranexamic acid in treatment of women with melasma: a double-blind randomized controlled trial Mawu, Ferra Olivia; Kapantow, Marlyn Grace; Pandaleke, Herry E. J.; Cahyadi, Alexandro Ivan; Togelang, Lidya; Tampi, Joan Alexandra; Christopher, Paulus Mario
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.213-219

Abstract

BackgroundMelasma is a highly prevalent chronic pigmentary disorder. The pathogenesis is unknown but melasma often occurs in photo-exposed areas, e.g., cheeks, upper lip, chin, and forehead. Tranexamic acid (TA), a plasmin inhibitor, aids in the inhibition of UV-induced plasmin activity and melanogenesis, making it a favorable therapeutic option for melasma. Tranexamic acid may be administered through various routes, e.g., topical. This study aimed to compare the efficacy of topical 10% versus 5% TA in women with melasma. MethodsThis double-blind randomized controlled trial included 16 females with epidermal type melasma who were randomized into two groups to receive either topical 10% TA (n = 8) or 5% TA (n = 8) applied twice daily for eight weeks. Prior to intervention and at 8 weeks after intervention, the intensity and extension of melasma were assessed based on melasma area and severity index (MASI) score and pigmentation score. ResultsMean MASI and pigmentation scores in both treatment groups were similar at base-line (p>0.05). The reduction in MASI and pigmentation scores in the topical 10% TA and 5% TA groups was similar and statistically not significant after 4 and 8 weeks of treatment (p>0.05). There were no drug-related adverse reactions or complications. ConclusionThis study demonstrated that topical 10% TA and 5% TA were effective in treating women with melasma. The utilization of topical 5% TA for melasma is a promising alternative therapeutic option without the need to increase the concentration of the formulation.
SATU KASUS NEKROLISIS EPIDERMAL TOKSIK PADA ANAK DIDUGA AKIBAT OBAT TRADISIONAL Putri, Devita; Adji, Aryani; Mamuaja, Enricco Hendra; Mawu, Ferra Olivia
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.502

Abstract

Pendahuluan: Nekrolisis epidermal toksik (NET) adalah reaksi mukokutan akut yang mengancam nyawa, ditandai dengan nekrosis dan pengelupasan epidermis luas. Kasus NET pada anak jarang terjadi, sekitar 0,4-1,2 juta per tahun. Sebagian besar kasus (60-90%) dipicu oleh obat, dan sebagian lainnya oleh infeksi virus atau bakteri. Tata laksana utama adalah menghentikan obat yang dicurigai sebagai penyebab dan terapi suportif. Prognosis kasus ini dinilai dengan Pediatric SCORTEN secara berkala. Kasus: Perempuan usia 13 bulan, mengalami ruam merah, lepuh, dan kulit mengelupas setelah mengonsumsi obat tradisional berbahan kulit kayu eboni, daun sirsak, dan daun mangga. Pemeriksaan fisik menunjukkan lesi makula eritematosa-hiperpigmentasi, multipel, bula multipel berdinding kendur, erosi, epidermolisis, dan tanda Nikolsky positif. Diagnosis NET ditegakkan berdasarkan anamnesis dan pemeriksaan fisik. Pasien mendapatkan terapi sistemik dan topikal dengan hasil perbaikan klinis signifikan setelah 20 hari. Diskusi: Obat tradisional mengandung komponen bioaktif yang diduga memicu NET, namun infeksi virus belum dapat disingkirkan sebagai penyebab. Kesimpulan: Telah dilaporkan satu kasus pada NET pada anak diduga akibat obat tradisional yang ditegakkan berdasarkan anamnesis dan pemeriksaan fisik. Meskipun jarang, obat tradisional perlu diwaspadai sebagai pencetus NET.
The efficacy of combination of oral antioxidants and topical retinoic acid versus topical retinoic acid monotherapy in mild acne vulgaris patients Mawu, Ferra Olivia; Kapantow, Marlyn Grace; Christopher, Paulus Mario
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.14640

Abstract

Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous follicle with multifactorial pathogenesis and pleiomorphic clinical manifestations constituting comedones, papules, pustules, nodules, and cysts. Oxidative stress has been reported to contribute in AV pathogenesis. This phenomenon rationalizes antioxidant supplementation as an adjuvant therapy for AV management. Four cases of 22 to 23 yo women with complaints of worsening facial acne for 1 to 6 mo. Initially, acne lesions appeared as skin-colored papules, which increased in number, became reddish papules and pustules, and extended to the jaw and chin. Lesions were accompanied by temporary itching and pain. Dermatological examination revealed multiple circumscribed discrete erythematous papules, miliar to lenticular in size, comedones (+), and pustules (+), with total lesions <30. According to the Lehmann criteria, patients were diagnosed as mild AV. All patients were treated with 0.025% topical retinoic acid cream, while the other two patients received additional oral antioxidant supplementations (zinc and ɑ-lipoic acid) and were followed up every two weeks. Two cases who received additional oral antioxidant supplementations (Group A) exhibited an earlier and higher clinical improvement, characterized by a reduction in the number of lesions on each follow up, till the current report. Oxidative stress in AV pathogenesis causes microenvironment alteration that favours colonization of Cutibacterium acnes. Together with the increase in sebum production, it stimulates the release of pro-inflammatory cytokines, such as interleukin (IL)-1α, IL-8, and tumor necrosis factor-α (TNF α), contributing to the inflammatory response. Antioxidant supplementation plays a role in suppressing the process of lipid peroxidation and inhibiting the expression of pro-inflammatory cytokines. Comprehensive management of AV is based on pathogenesis and the role of oxidative stress. An earlier and higher clinical improvement reduction was noted in Group A, patients who received a combination of 0.025% topical retinoic acid cream and oral antioxidant supplementation.
Successful Management of Post-Excisional Biopsy Dehisced Wound with 1% Framycetin Sulphate and Ozonated Oil Adjuvant: A Case Report Mawu, Ferra Olivia; Sondakh, O. Reymond L.; Tampi, Joan Alexandra; Christopher, Paulus Mario
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25956

Abstract

Background: Wound dehiscence is wound edges separation due to disrupted wound healing. Wound dehiscence is a complication in 8% of dermatologic surgeries. In this case, secondary infection of the wound occurred, 1% framycetin sulphate tulle was then chosen to interfere microbial protein synthesis, combined with ozonated oil as adjuvant therapy. Ozone oxidizes bacterial phospholipids and lipoproteins, promotes local tissue metabolism, stimulates fibroblast proliferation, facilitates collagen fiber formation, and supports angiogenesis. This case report described a post-excisional biopsy dehisced wound that was treated with 1% framycetin sulphate tulle and ozonated oil, and this case is the first to report a successful management of post-excisional biopsy dehisced wound with ozonated oil as adjuvant. Case Presentation: An 11-year-old female was brought with a purulent wound on her head post-excisional biopsy. Examination of the parietal region showed a solitary ulcer, 1 cm in diameter, irregular edge, granulated tissue base, serous exudate, crusting, edema, and pus. Treatment was 0.9% NaCl compress, 1% framycetin sulphate tulle, and ozonated oil once weekly. Evaluation on day 21 showed ulcer size reduction and on day 28, ulcer turned into a scar, treatment was continued with mometasone 0.1% cream. Day 86 showed secondary cicatricial alopecia. Complications of a wound in hair-bearing area can occur, in this case, secondary cicatricial alopecia.Conclusion: This paper highlights the utilization of ozonated oil as an adjuvant therapy for a favorable outcome in wound healing.
Co-Authors Adji, Aryani Cahyadi, Alexandro Ivan Christopher, Paulus Mario Elrovita Donata Herry E. J. Pandaleke Lidya Togelang Mamuaja, Enricco Hendra Marlyn Grace Kapantow Marlyn Grace Kapantow Oktavia Reymond L. Sondakh Paulus Mario Christopher Putri, Devita Sondakh, O. Reymond L. Tampi, Joan Alexandra