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All Journal Jurnal Respirasi (JR) Malang Respiratory Journal International Journal of Radiology and Imaging
Karliasari, Liana
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Neutrophil-Lymphocyte Ratio (NLR) as a Prognostic Marker in Advanced Lung Cancer Patients Undergoing First-Line Treatment Dewi, Dinda Ary Miranda; Setyawan, Ungky Agus; Karliasari, Liana
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.209-213

Abstract

Introduction: Neutrophil-lymphocyte ratio (NLR) is one of the systemic inflammatory markers that play a role in detecting the degree of sepsis in the cancer microenvironment. A high NLR, with a dominant predominance of neutrophil cells, can release cytokines and chemokines that induce cancer cell proliferation and metastasis. Conversely, a low NLR, predominately of lymphocyte cells, can activate the immune system to handle chronic inflammation. From its mechanism of action, NLR is often used to predict the future prognosis and survival rate of cancer patients. This study aimed to analyze the effect of first-line therapy in lung cancer patients with an alternative prognostic indicator in the form of changes in NLR values confirmed by the response evaluation criteria in solid tumors (RECIST). Methods: This study used an analytical observational method with a cross-sectional approach and was conducted using secondary data samples from the medical records of lung cancer patients treated at Dr. Saiful Anwar General Hospital, Malang. Results: Spearman’s correlation analysis between NLR and RECIST revealed a relationship (p = 0.001). Determining the NLR cut-off point using the receiver operating characteristic (ROC) curve yielded a value of 3.55, with NLR sensitivity and specificity at 69.44% and 69.76%, respectively. The therapy administration to lung cancer patients significantly decreased NLR (p = 0.032). Conclusion: NLR is a valuable tool for routinely monitoring therapy outcomes in lung cancer patients and can be considered an alternative prognostic marker due to its promising results.
IMAGING OF SEVERE RENAL AND LIVER INJURY ON A TRAUMA PATIENT: A CASE REPORT Pamarta, Trisna Belani; Nabila, Astrid Hanan; Karliasari, Liana
International Journal of Radiology and Imaging Vol. 3 No. 02 (2024): International Journal of Radiology and Imaging
Publisher : Department of Radiology, Medical Faculty, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijri.2024.003.02.5

Abstract

Blunt abdominal trauma accounts for the most abdominal injuries. A quick yet accurate examination must be carried out immediately to identify and promptly address the cause of the internal bleeding. In this case report, we describe A 17-year-old girl who was taken to the emergency room after she lost consciousness following a traffic accident. The patient presented with unstable hemodynamics indicating signs of hemorrhagic shock. The patient then underwent a CT examination with contrast to determine the diagnosis. The patient was diagnosed with internal bleeding with unstable hemodynamics due to liver injury AAST grade IV and renal trauma AAST grade III. In this case, signs of kidney and liver trauma can be recognized, such as fluid accumulation and the severity of injury to each organ. This case report aims to increase awareness of the signs of intra-abdominal bleeding and its severity so that appropriate treatment can be determined immediately. Keywords: renal injury, liver injury, abdominal CT-Scan
A Young Women With Infected Bronchiectasis and Paraseptal Emphysema Mafisah, Saidah; Sugiri, Yani Jane; Sartono, Teguh Rahayu; Karliasari, Liana
Malang Respiratory Journal Vol. 7 No. 1 (2025): March 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.01.03

Abstract

Introduction: Bronchiectasis is defined as an abnormal dilation of the bronchi, usually as a result of chronic airway inflammation and/or infection. Bronchiectasis with non-mycobacterial tuberculosis infection is more common in women. Paraseptal emphysema formed around the pleura or septa in the upper lobe, caused by repeated infections, smoking, or deficiency of the alpha 1 antitrypsin enzyme. Emphysema is more common in men with a history of smoking. Case: A 22 year-old female came with chief complaint of chronic cough. No smoking history. Patient had a history of repeated hospitalizations due to pneumonia. Fungal culture results with no fungal growth and sputum molecular rapid test result is mycobacterium tuberculosis not detected. Achromobacter denitrificans Multiple Drug Resistance was found through bronchial washings culture. Thorax Computed Tomography Scan showed cavities connected to the bronchi with air fluid level (infected bronchiectasis) and air space in upper lobes (paraseptal emphysema). Patient was given definitive antibiotic and clinically improved. Discussion: Bronchiectasis and paraseptal emphysema are caused recurrent lung infections. Bronchiectasis with non-mycobacterial tuberculosis infection is more common in women. In this case, we found infected bronchiectasis and paraseptal emphysema in a young women with no history of smoking but with a history of recurrent pneumonia. Conclusion: Possible causes of bronchiectasis and paraseptal emphysema in this patient was due to recurrent lung infection. The patient had been given definitive antibiotic treatment and clinically improve now. In addition, appropriate and adequate therapy are needed to reduce progression and complications of this disease.
THE EFFECT OF RADIATION PROTECTION ON THE DEVELOPMENT OF THYROID NODULES AMONG RADIOGRAPHERS IN MALANG Aisy, Rahmi Mufidah; Aurora, Habiba; Karliasari, Liana
International Journal of Radiology and Imaging Vol. 2 No. 01 (2023): International Journal of Radiology and Imaging
Publisher : Department of Radiology, Medical Faculty, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776//ub.ijri.2023.002.01.4

Abstract

The use of radiation technology in Indonesia is mostly applied in the medical world and is immensely beneficial, but radiation exposure also has negative effects on health in the form of deterministic and stochastic effects. The thyroid gland is at a high risk of radiation exposure, which leads to the development of thyroid nodules. To prevent that, there must be safety measures in the use of radiation technology by implementing radiation protection, such as a thyroid shield. This study aims to examine the effect of the compliant use of a thyroid shield on the development of thyroid nodules among radiographers in Malang. This study is an observational study with the use of secondary data, where the primary data were previously gathered cross-sectionally in April 2021. The data from 40 subjects were then analyzed using a T-test with the result of the t-value = 4.299 and α = 0.000. With the result of α < 0.05 and t-value > t-distribution, this study concludes that the use of a thyroid shield has an effect on the development of thyroid nodules among radiographers in Malang, and compliant use can lower the incidence of thyroid nodules. Keywords: Radiation exposure, radiographer, thyroid nodule, thyroid
Co-Authors Aisy, Rahmi Mufidah Dewi, Dinda Ary Miranda Habiba Aurora Mafisah, Saidah Nabila, Astrid Hanan Pamarta, Trisna Belani Sartono, Teguh Rahayu Setyawan, Ungky Agus Sugiri, Yani Jane