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Maulidyah, Maulidyah
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Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Transportation

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Tinjauan Waktu Dan Biaya Menggunakan Metode Crashing Dengan Sistem Shift Tenaga Kerja: Tinjauan Waktu Dan Biaya Menggunakan Metode Crashing Dengan Sistem Shift Tenaga Kerja Maulidyah, Maulidyah; rizkiyah, sri; Arena, Azza; Purnama, Ikhwan Arief
RETENSI Vol. 3 No. 1 (2022): Retensi
Publisher : Jurusan Teknik Sipil Polnep

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31573/retensi.v3i1.502

Abstract

Pada saat membangun proyek gedung, keterlambatan pekerjaan proyek sering terjadi saat dilaksanakan. Jadi dibutuhkan alternatif yang dapat membantu menyelesaikan proyek konstruksi lebih cepat salah satunya dengan menggunakan metode shift tenaga kerja. Penelitian ini menganalisis percepatan periode menggunakan shift tenaga kerja pada proyek konstruksi gedung SMAN 4 Kota Pontianak Kalimantan Barat. Total anggaran biaya proyek pada kondisi pasca-crashing dengan sistem shift tenga kerja dengan total biaya Rp2.731.667.460,24 lebih tinggi dari total anggaran proyek dalam kondisi normal yaitu Rp. 2.222.022.510,48, dan periode pelaksanaan proyek 77 hari lebih cepat dari periode normal dari 180 hari pada durasi normal Dapat disimpulkan bahwa penerapan sistem shift lebih efektif dalam durasi karena lebih cepat dari rencana durasi normal. Menjadi efektif dan efisien dalam proyek konstruksi sangat penting karena ada banyak mekanisme kerja yang saling mempengaruhi seperti biaya, waktu, sumber daya manusia, sistem manajemen kesehatan dan keselamatan kerja (SMK3) untuk identifikasi resiko yang kemungkinan terjadi dalam proyek konstruksi, dan manajemen komunikasi proyek sangat penting dalam konstruksi.
In Vitro Anti-Inflammatory Potential of Buton Forest Honey through Nitric Oxide Inhibition in RAW 264.7 Macrophage Cells Hariana, Hariana; Wahyuni, Wahyuni; Suryani, Suryani; Sartinah, Ari; Maulidyah, Maulidyah; Yodha, Agung Wibawa Mahatva; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.396

Abstract

Inflammation is a physiological defense response to injury, infection, or stress, mediated by various signaling molecules, including nitric oxide (NO). However, excessive NO production can contribute to tissue damage and the progression of inflammatory conditions. Honey, a natural product derived from floral nectar by bees, contains diverse bioactive compounds with potential pharmacological properties, including anti-inflammatory activity. Buton Regency, located in Southeast Sulawesi, is a major producer of forest honey, making it a promising source of bioactive honey with therapeutic potential. This study aimed to evaluate the in vitro anti-inflammatory activity of Buton forest honey by assessing its ability to inhibit NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results demonstrated that Buton forest honey significantly suppressed NO production in a concentration-dependent manner. At concentrations of 500, 250, 125, 62.5, 31.25, 15.63, 7.81, and 3.91 mg/L, the percentages of inhibition were 94.69 ± 2.94%, 74.03 ± 2.43%, 67.40 ± 2.34%, 62.72 ± 3.09%, 51.80 ± 4.73%, 44.40 ± 4.73%, 19.06 ± 1.79%, and 12.82 ± 0.68%, respectively. Statistical analysis using one-way ANOVA followed by post hoc testing revealed significant differences among the tested concentrations (p 0.05). In conclusion, Buton forest honey exhibits significant anti-inflammatory activity by inhibiting NO production in macrophage cells, suggesting its potential as a natural source for the development of anti-inflammatory agents.
Co-Authors Arena, Azza Ari Sartinah, Ari Fristiohady, Adryan Hariana, Hariana ikhwan Arief Purnama Purnama, La Ode Muhammad Julian rizkiyah, sri Suryani Suryani wahyuni wahyuni Yodha, Agung Wibawa Mahatva