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Jaya, La Ode Irman
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Agriculture, Biological Sciences & Forestry

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Topical Ointment Anredera cordifolia Leaves Ethanolic Extract-Loaded Nanochitosan Promotes Wound Healing in Hyperglycemic Rat Alfatinnisa, Zalfa; Andriyan, Mohammad Wahyu; Saputra, Muhammad Ragil; Astuti, Endah Puji; Sunarno, Sunarno; Isdadiyanto, Sri; Subagio, Agus; Jaya, La Ode Irman
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.1842

Abstract

Wound healing in hyperglycemia patients is still a challenge in the medical field. Bioactive compounds of binahong leaf extract can support the wound healing process. Nanoencapsulation of the extract can avoid oxidation and optimize drug delivery to target tissues. This study aimed to analyze the effect of nanochitosan encapsulated binahong extract ointment (NEBE/Oint) on the percentage of wound healing, angiogenesis, collagen density, and epithelial thickness in hyperglycemic rats. This study used 80 mg/kg streptozotocin-induced hyperglycemia rats injured in the back area. Rats were divided into P0 (0,9% NaCl), P1 (10% povidone-iodine ointment (PI/Oint)), P2 (10% NEBE/Oint), P3 (20% NEBE/Oint), P4 (30% NEBE/Oint). Phytochemical screening of binahong leaves extract showed positive results for flavonoids, alkaloids, saponins, and tannins. NEBE particle size was 169 nm with a size distribution of 0.2 and a zeta potential value of -40,2 mV. The results showed NEBE ointment had a significant effect when compared with negative control on wound healing hyperglycemic rats. The conclusion is that nanochitosan drug delivery has the potential as an alternative wound treatment. The novelty of this study is the use of nanochitosan to accelerate wound healing in hyperglycemic rats. The results of this study are expected to become a reference for new wound-healing methods in the medical field.
Effects of Spirulina Feed Additive on Duodenal Tissue Structure in Peking Duck (Anas platyrhynchos) Maura, Maisya Sifana; Sunarno, Sunarno; Budiraharjo, Kustopo; Djaelani, Muhammad Anwar; Jaya, La Ode Irman
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.26215

Abstract

The use of synthetic feed additives in Peking ducks has adverse effects on their growth and productivity. Spirulina sp., a blue-green algae, has the potential to be used as a safe feed additive that can enhance the growth and productivity of ducks. This study aims to analyze the effects of Spirulina (Spirulina sp.) powder as a feed additive on the histomorphometry of the duodenum in Peking ducks (Anas platyrhynchos), focusing on the duodenal lumen diameter, villus height, villus width, mucosal tunic thickness, submucosal tunic thickness, and muscular tunic thickness. This study used a Completely Randomized Design (CRD) with 35 ducks divided into 5 treatments and 5 repetitions. The treatments included a control group and the addition of spirulina powder in feed at concentrations of 2.5%, 5%, 7.5%, and 10%. The data were analyzed by ANOVA with a significance level of 5%, followed by Duncan's test. The results of data analysis showed that spirulina powder had a significant effect (P<0.05) on villus height and duodenal mucosa tunica thickness. The conclusion of this study is that spirulina powder has the potential to be used as a feed additive to improve digestive performance in male Peking ducks, as evidenced by the increase in villus height and thick tunica mucosa in the small intestine. The novelty of this study lies in the utilization of spirulina powder as a feed additive to increase the size of the duodenal tissue structure in Peking ducks. The results of this study are expected to be a new reference on the potential of spirulina as a feed additive to improve poultry feed quality and digestive performance, especially in peking ducks.
The Potential of Spirulina Powder as Feed Additive on Hepatic Histomorphometry in Peking Ducks (Anas platyrhynchos) Budiwardani, Dwinanda; Sunarno, Sunarno; Budiraharjo, Kustopo; Isdadiyanto, Sri; Jaya, La Ode Irman
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 3 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i3.9246

Abstract

Providing standard feed to support and improve the growth, productivity, health, and digestibility of livestock still requires feed additives, one of which is the natural feed additive spirulina flour. Spirulina flour was one of the natural feed additives chosen because it contained bioactive compounds, had no side effects on livestock, and substitute for antibiotics for livestock, so it could increase the growth, productivity, health, and digestibility of Peking ducks. The aim of this study was to analyze the effect of spirulina flour feed additive on Peking duck liver histomorphometry. This research used a Completely Randomized Design (CRD) with 5 types of spirulina flour concentration treatments (0%, 2.5%, 5%, 7.5%, and 10%) and 5 replications including 5 ducks in each replication. The treatment groups included P0, P1, P2, P3, and P4. Measurement variables included liver weight, hepatosomatic index, hepatocyte and central vein diameter, and sinusoid width. The data obtained were analyzed by the Analysis of Variance (ANOVA) test with a confidence level of 95%. The results showed that the addition of spirulina flour as a feed additive had no effect on liver weight, hepatosomatic index, hepatocyte diameter, central vein diameter, and sinusoid width. The conclusion of this research was that added spirulina flour (Spirulina sp.) feed additive potentially maintained the histomorphometry of the Peking duck liver organ.
Co-Authors Agus Subagio Alfatinnisa, Zalfa Andriyan, Mohammad Wahyu Budiwardani, Dwinanda Endah Puji Astuti, Endah Puji Kustopo Budiraharjo Maura, Maisya Sifana Muhammad Anwar Djaelani Saputra, Muhammad Ragil Sri Isdadiyanto Sunarno Sunarno