Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Journal of Pharmaceuticals and Natural Sciences
Rahmaharva, Naila Dwi
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The potency of bioactive constituents in Piper betle L. for Alzheimer Targeting on Caspase-3 - in silico studies Putri, Anindya Calista Nabila; Ashriany, Raissa Rerey; Salsabila, Sitti Kesya; Rahmaharva, Naila Dwi; Muljono, Fajar Oktavian; Fardhan, Firghi Muhammad; Novitasari, Dhania
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/rw708r52

Abstract

Alzheimer’s disease (AD) is a neurodegenerative condition that can disrupt memory, cognition, and neurological functions, Recent studies highlight caspase-3 as a potential target, with several lines of evidence pointing to the enzyme's possible role in the onset of AD. Several findings revealed that betel leaf was also examined to treat AD by targeting acetylcholinesterase in vitro and in silico, yet no evaluation had not been done in caspase-3 activity. Using molecular docking, Lipinski's and PreADMET prediction, an in-silico analysis of compounds found in betel leaf (Piper betle L.) was conducted in order to determine whether these compounds could be applied as therapeutic candidates in the treatment of Alzheimer's. To ascertain the drug similarity and ADMET profile of the evaluated ligands, the Mcule and PreADMET sites were used in the studies, which were followed by the molecular docking simulation software AutoDock. The findings demonstrated that all the tested compounds passed the physicochemical features based on Lipinski rule. Further analysis then showed that arecoline bound to the critical amino acid that involved in caspase-3 inhibition. Further evaluation needs to be done to confirm the molecular mechanism of P. betle leaves to AD.
Penguatan Peran Masyarakat dalam Pencegahan dan Pengobatan Tuberkulosis: Desa Nanggela, Kecamatan Mandirancan, Kabupaten Kuningan Yunivita, Vycke; Bernadus, Cheryl Antoinette; Mariska, Nathania; Rahmaharva, Naila Dwi; Ruslami, Rovina
DHARMAKARYA: Jurnal Aplikasi Ipteks untuk Masyarakat Vol 14, No 3 (2025): Dharmakarya
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v14i3.63219

Abstract

Jawa Barat masih menjadi daerah dengan kasus tuberkulosis terbanyak di Indonesia. Kabupaten Kuningan menjadi salah satu daerah yang masih menghadapi tantangan penanggulangan tuberkulosis. Pengabdian masyarakat dilaksanakan di Desa Nanggela, Kecamatan Mandirancan, Kabupaten Kuningan dengan bekerja sama dengan Rumah Sakit Paru Sidawangi dan Puskesmas Kecamatan Mandirancan sebagai upaya peningkatan kesadaran masyarakat akan tuberkulosis serta berperan dalam pencegahan penyebarluasan tuberkulosis. Kegiatan dilaksanakan dalam empat rangkaian, yaitu tiga intervensi dan satu kegiatan utama. Intervensi dilakukan dalam bentuk edukasi kepada kelompok masyarakat yang berbeda, yaitu edukasi pola hidup bersih dan sehat kepada ibu hamil, edukasi pola makan sehat kepada peserta didik tingkat sekolah dasar, dan edukasi pola hidup sehat kepada lansia yang diharapkan dapat meningkatkan wawasan masyarakat akan pola hidup bersih dan sehat untuk mencegah penyebarluasan tuberkulosis. Berdasarkan penilaian dari masing-masing intervensi, terdapat peningkatan pemahaman masyarakat akan pola hidup bersih dan sehat secara keseluruhan. Kegiatan utama dilaksanakan dengan dua rangkaian utama, yaitu pemeriksaan kesehatan dan edukasi mengenai tuberkulosis. Kegiatan berhasil menarik peserta dari Desa Nanggela dan sekitarnya serta diharapkan berhasil meningkatkan wawasan mengenai tuberkulosis, terutama dalam pencegahannya.
Co-Authors Ashriany, Raissa Rerey Bernadus, Cheryl Antoinette Dhania Novitasari Fardhan, Firghi Muhammad Mariska, Nathania Muljono, Fajar Oktavian Putri, Anindya Calista Nabila Rovina Ruslami, Rovina Salsabila, Sitti Kesya Yunivita, Vycke